Trace level determination of eleven nervous system–active pharmaceutical ingredients by switchable solvent-based liquid-phase microextraction and gas chromatography–mass spectrometry with matrix matching calibration strategy
This study utilized switchable solvent liquid-phase microextraction (SS-LPME) to enrich eleven nervous system active pharmaceutical ingredients (APIs) from aqueous samples for their determination at trace levels by gas chromatography mass spectrometry. The analytes selected for the study included AP...
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| Veröffentlicht in: | Environmental monitoring and assessment 2022-02, Vol.194 (2), p.58-58, Article 58 |
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| creator | Bozyiğit, Gamze Dalgıç Ayyıldız, Merve Fırat Chormey, Dotse Selali Engin, Güleda Onkal Bakırdere, Sezgin |
| description | This study utilized switchable solvent liquid-phase microextraction (SS-LPME) to enrich eleven nervous system active pharmaceutical ingredients (APIs) from aqueous samples for their determination at trace levels by gas chromatography mass spectrometry. The analytes selected for the study included APIs utilized in antidepressant, antipsychotic, antiepileptic, and anti-dementia drugs. Parameters of the microextraction method including switchable solvent volume, concentration and volume of the trigger agent (sodium hydroxide), and sample agitation period were optimized univariately to boost extraction efficiency. Under the optimum conditions, the detection limits calculated for the analytes were in the range of 0.20–8.0 ng/mL, and repeatability for six replicate measurements as indicated by percent relative standard deviation values were below 10%. Matrix matching calibration strategy was used to enhance quantification accuracy for the analytes. The percent recovery results calculated for the eleven analytes ranged between 86 and 117%. |
| doi_str_mv | 10.1007/s10661-021-09708-5 |
| format | Article |
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The analytes selected for the study included APIs utilized in antidepressant, antipsychotic, antiepileptic, and anti-dementia drugs. Parameters of the microextraction method including switchable solvent volume, concentration and volume of the trigger agent (sodium hydroxide), and sample agitation period were optimized univariately to boost extraction efficiency. Under the optimum conditions, the detection limits calculated for the analytes were in the range of 0.20–8.0 ng/mL, and repeatability for six replicate measurements as indicated by percent relative standard deviation values were below 10%. Matrix matching calibration strategy was used to enhance quantification accuracy for the analytes. The percent recovery results calculated for the eleven analytes ranged between 86 and 117%.</description><identifier>ISSN: 0167-6369</identifier><identifier>EISSN: 1573-2959</identifier><identifier>DOI: 10.1007/s10661-021-09708-5</identifier><identifier>PMID: 34989878</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antidepressants ; Antiepileptic agents ; Antipsychotics ; Atmospheric Protection/Air Quality Control/Air Pollution ; Calibration ; Chromatography ; Dementia disorders ; Detection limits ; Earth and Environmental Science ; Ecology ; Ecotoxicology ; Environment ; Environmental Management ; Environmental Monitoring ; Environmental science ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; Hydroxides ; Ingredients ; Limit of Detection ; Liquid Phase Microextraction ; Liquid phases ; Mass spectrometry ; Mass spectroscopy ; Matching ; Mathematical analysis ; Monitoring/Environmental Analysis ; Nervous system ; Nervous System - chemistry ; Pharmaceutical Preparations ; Pharmaceuticals ; Scientific imaging ; Sodium ; Sodium hydroxide ; Solvents ; Spectroscopy ; Trace levels ; Water Pollutants, Chemical - analysis</subject><ispartof>Environmental monitoring and assessment, 2022-02, Vol.194 (2), p.58-58, Article 58</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-191d903b1dc4c6d0638e035a05d298971a0e179bb3512ae97d192fae9b8b39273</citedby><cites>FETCH-LOGICAL-c375t-191d903b1dc4c6d0638e035a05d298971a0e179bb3512ae97d192fae9b8b39273</cites><orcidid>0000-0003-3523-8169 ; 0000-0002-7412-7800 ; 0000-0001-9746-3682 ; 0000-0002-3841-8440 ; 0000-0002-8129-7488</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10661-021-09708-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10661-021-09708-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34989878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozyiğit, Gamze Dalgıç</creatorcontrib><creatorcontrib>Ayyıldız, Merve Fırat</creatorcontrib><creatorcontrib>Chormey, Dotse Selali</creatorcontrib><creatorcontrib>Engin, Güleda Onkal</creatorcontrib><creatorcontrib>Bakırdere, Sezgin</creatorcontrib><title>Trace level determination of eleven nervous system–active pharmaceutical ingredients by switchable solvent-based liquid-phase microextraction and gas chromatography–mass spectrometry with matrix matching calibration strategy</title><title>Environmental monitoring and assessment</title><addtitle>Environ Monit Assess</addtitle><addtitle>Environ Monit Assess</addtitle><description>This study utilized switchable solvent liquid-phase microextraction (SS-LPME) to enrich eleven nervous system active pharmaceutical ingredients (APIs) from aqueous samples for their determination at trace levels by gas chromatography mass spectrometry. The analytes selected for the study included APIs utilized in antidepressant, antipsychotic, antiepileptic, and anti-dementia drugs. Parameters of the microextraction method including switchable solvent volume, concentration and volume of the trigger agent (sodium hydroxide), and sample agitation period were optimized univariately to boost extraction efficiency. Under the optimum conditions, the detection limits calculated for the analytes were in the range of 0.20–8.0 ng/mL, and repeatability for six replicate measurements as indicated by percent relative standard deviation values were below 10%. Matrix matching calibration strategy was used to enhance quantification accuracy for the analytes. The percent recovery results calculated for the eleven analytes ranged between 86 and 117%.</description><subject>Antidepressants</subject><subject>Antiepileptic agents</subject><subject>Antipsychotics</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Calibration</subject><subject>Chromatography</subject><subject>Dementia disorders</subject><subject>Detection limits</subject><subject>Earth and Environmental Science</subject><subject>Ecology</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Management</subject><subject>Environmental Monitoring</subject><subject>Environmental science</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>Hydroxides</subject><subject>Ingredients</subject><subject>Limit of Detection</subject><subject>Liquid Phase Microextraction</subject><subject>Liquid phases</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Matching</subject><subject>Mathematical analysis</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nervous system</subject><subject>Nervous System - 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The analytes selected for the study included APIs utilized in antidepressant, antipsychotic, antiepileptic, and anti-dementia drugs. Parameters of the microextraction method including switchable solvent volume, concentration and volume of the trigger agent (sodium hydroxide), and sample agitation period were optimized univariately to boost extraction efficiency. Under the optimum conditions, the detection limits calculated for the analytes were in the range of 0.20–8.0 ng/mL, and repeatability for six replicate measurements as indicated by percent relative standard deviation values were below 10%. Matrix matching calibration strategy was used to enhance quantification accuracy for the analytes. 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| ispartof | Environmental monitoring and assessment, 2022-02, Vol.194 (2), p.58-58, Article 58 |
| issn | 0167-6369 1573-2959 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antidepressants Antiepileptic agents Antipsychotics Atmospheric Protection/Air Quality Control/Air Pollution Calibration Chromatography Dementia disorders Detection limits Earth and Environmental Science Ecology Ecotoxicology Environment Environmental Management Environmental Monitoring Environmental science Gas chromatography Gas Chromatography-Mass Spectrometry Hydroxides Ingredients Limit of Detection Liquid Phase Microextraction Liquid phases Mass spectrometry Mass spectroscopy Matching Mathematical analysis Monitoring/Environmental Analysis Nervous system Nervous System - chemistry Pharmaceutical Preparations Pharmaceuticals Scientific imaging Sodium Sodium hydroxide Solvents Spectroscopy Trace levels Water Pollutants, Chemical - analysis |
| title | Trace level determination of eleven nervous system–active pharmaceutical ingredients by switchable solvent-based liquid-phase microextraction and gas chromatography–mass spectrometry with matrix matching calibration strategy |
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