Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. The possible role of biological abnormalities in the etiopathogenesis...
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| Veröffentlicht in: | Journal of molecular neuroscience 2022-04, Vol.72 (4), p.741-747 |
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| creator | Nalbant, Kevser Erden, Semih Yazar, Abdullah Kılınç, İbrahim |
| description | Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. The possible role of biological abnormalities in the etiopathogenesis of this disorder arouses research interest in this area. This is a case–control study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (
n
= 60) and controls (
n
= 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autism symptom levels in all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels items mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment. |
| doi_str_mv | 10.1007/s12031-021-01954-z |
| format | Article |
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n
= 60) and controls (
n
= 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autism symptom levels in all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels items mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.</description><identifier>ISSN: 0895-8696</identifier><identifier>EISSN: 1559-1166</identifier><identifier>DOI: 10.1007/s12031-021-01954-z</identifier><identifier>PMID: 34988901</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abnormalities ; Autism ; Autism Spectrum Disorder ; Autistic children ; Autistic Disorder ; Automobiles ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Cell Biology ; Child ; Children ; Enzyme-linked immunosorbent assay ; Humans ; Neurochemistry ; Neurodevelopmental Disorders ; Neurology ; Neurosciences ; Occludin ; Proteomics ; Social behavior ; Social factors</subject><ispartof>Journal of molecular neuroscience, 2022-04, Vol.72 (4), p.741-747</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-b78bc1aff7a6c791521eaece14d61daed5e0ccd295acd79f9652ff2d83516b303</citedby><cites>FETCH-LOGICAL-c419t-b78bc1aff7a6c791521eaece14d61daed5e0ccd295acd79f9652ff2d83516b303</cites><orcidid>0000-0003-4261-1013</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12031-021-01954-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12031-021-01954-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34988901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nalbant, Kevser</creatorcontrib><creatorcontrib>Erden, Semih</creatorcontrib><creatorcontrib>Yazar, Abdullah</creatorcontrib><creatorcontrib>Kılınç, İbrahim</creatorcontrib><title>Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder</title><title>Journal of molecular neuroscience</title><addtitle>J Mol Neurosci</addtitle><addtitle>J Mol Neurosci</addtitle><description>Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by limitations in mutual communication and social interaction as well as restricted, repetitive patterns of behaviors, interests, or activities. The possible role of biological abnormalities in the etiopathogenesis of this disorder arouses research interest in this area. This is a case–control study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (
n
= 60) and controls (
n
= 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autism symptom levels in all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels items mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.</description><subject>Abnormalities</subject><subject>Autism</subject><subject>Autism Spectrum Disorder</subject><subject>Autistic children</subject><subject>Autistic Disorder</subject><subject>Automobiles</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Child</subject><subject>Children</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Humans</subject><subject>Neurochemistry</subject><subject>Neurodevelopmental Disorders</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Occludin</subject><subject>Proteomics</subject><subject>Social behavior</subject><subject>Social factors</subject><issn>0895-8696</issn><issn>1559-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1OFjEUhhsjkU_0BlyYJm7cjPR0ZtrpEj9BSUhMQNdNpz0DJfNn24F83AC3TWUQExcumpO2z3n68xLyDtgnYEweRuCshILxPEDVVXH3gmygrlUBIMRLsmGNqotGKLFPXsd4zTJZQfOK7JeVahrFYEPuT8cbjMlfmuSnkU4dTVdIz7Ff5y2mW8SRHs8-r_fe9PSzCcFjoCfLaB8ZMzp6tCQfB3qxG-Y05Yo3GHzaUT_S7ZXvXciO26x4Bme0KSwD_eLjFByGN2SvM33Et0_1gPw8Of6x_Vacff96uj06K2wFKhWtbFoLpuukEVYqqDmgQYtQOQHOoKuRWeu4qo11UnVK1LzruGvKGkRbsvKAfFy9c5h-LfnlevDRYt-bEaclai5AcikBmox--Ae9npYw5ttlqpKVKBsGmeIrZcMUY8BOz8EPJuw0MP07Jr3GpPPn68eY9F1uev-kXtoB3XPLn1wyUK5AzFvjJYa_Z_9H-wAX0qDg</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Nalbant, Kevser</creator><creator>Erden, Semih</creator><creator>Yazar, Abdullah</creator><creator>Kılınç, İbrahim</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4261-1013</orcidid></search><sort><creationdate>20220401</creationdate><title>Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder</title><author>Nalbant, Kevser ; 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The possible role of biological abnormalities in the etiopathogenesis of this disorder arouses research interest in this area. This is a case–control study evaluating epithelial barrier function by comparing serum concentrations of occludin and zonulin in children with ASD (
n
= 60) and controls (
n
= 30). The Childhood Autism Rating Scale (CARS) was used to evaluate autism symptom levels in all children. Serum occludin and zonulin levels were analyzed using an enzyme-linked immunosorbent assay. Serum occludin was significantly lower in children with ASD than in control subjects. In children with ASD, a decrease in occludin level was significantly associated with the disorder symptom levels items mean score (CARS total scores). Our findings showed that children with ASD had alterations in epithelial barrier function compared to the control group. The investigation of the mechanism underlying the different levels of occludin between ASD and controls may be of importance in clarifying the etiopathogenesis of ASD, as well as its follow-up and treatment.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34988901</pmid><doi>10.1007/s12031-021-01954-z</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4261-1013</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of molecular neuroscience, 2022-04, Vol.72 (4), p.741-747 |
| issn | 0895-8696 1559-1166 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Abnormalities Autism Autism Spectrum Disorder Autistic children Autistic Disorder Automobiles Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Child Children Enzyme-linked immunosorbent assay Humans Neurochemistry Neurodevelopmental Disorders Neurology Neurosciences Occludin Proteomics Social behavior Social factors |
| title | Investigation of the Relation between Epithelial Barrier Function and Autism Symptom Severity in Children with Autism Spectrum Disorder |
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