An update on male infertility and intratesticular testosterone—insight into novel serum biomarkers
Intratesticular testosterone is vital for spermatogenesis, male fertility, and virility. Currently the only method to assess levels of intratesticular testosterone is to perform testicular biopsy which is invasive and can lead to several complications. Approaches to assess intratesticular testostero...
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| Veröffentlicht in: | International journal of impotence research 2022-11, Vol.34 (7), p.673-678 |
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| container_title | International journal of impotence research |
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| creator | Sidhom, Karim Panchendrabose, Kapilan Mann, Uday Patel, Premal |
| description | Intratesticular testosterone is vital for spermatogenesis, male fertility, and virility. Currently the only method to assess levels of intratesticular testosterone is to perform testicular biopsy which is invasive and can lead to several complications. Approaches to assess intratesticular testosterone have been understudied but hold promise as future male contraceptive agents and may grant the ability to monitor patients undergoing hormonal changes from therapeutic and diagnostic perspectives. Previous studies have sought to assess the utility of 17-hydroxyprogesterone (17-OHP) and insulin-like factor 3 (INSL3) as accurate surrogate biomarkers of intratesticular testosterone. The aim of this review is thus to highlight the importance of intratesticular testosterone and the consequent advances that have been made to elucidate the potential of biomarkers for intratesticular testosterone in the context of male infertility. |
| doi_str_mv | 10.1038/s41443-021-00507-7 |
| format | Article |
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| source | Alma/SFX Local Collection |
| subjects | 692/53/2421 692/700/565/238 Biomarkers Infertility Medicine Medicine & Public Health Mens health Reproductive Medicine Review Article rology Testes Testosterone Urology |
| title | An update on male infertility and intratesticular testosterone—insight into novel serum biomarkers |
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