Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis
Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression, and lncRNA expression levels could serve as a potential molecular biomarker for the prognosis and diagnosis of some cancers. However, the prognostic value of lncRNAs in oral squamous cell carcinoma (OSCC) remains...
Gespeichert in:
| Veröffentlicht in: | Disease markers 2021, Vol.2021, p.6407528-9 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | |
| container_start_page | 6407528 |
| container_title | Disease markers |
| container_volume | 2021 |
| creator | Wang, Yu Wang, Peng Liu, Xin Gao, Ziran Cao, Xianbao Zhao, Xilong |
| description | Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression, and lncRNA expression levels could serve as a potential molecular biomarker for the prognosis and diagnosis of some cancers. However, the prognostic value of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. Thus, a meta-analysis was conducted to explore the potential prognostic value of lncRNAs in OSCC. We systematically searched PubMed, EBSCO, Web of Science, and Elsevier from 2005 to 2021 to identify all published studies that reported the association between lncRNAs and prognosis in OSCC. Then, we used meta-analytic methods to identify the actual effect size of lncRNAs on cancer prognosis. The hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. The reliability of those results was then examined using measures of heterogeneity and testing for selective reporting biases. According to the inclusion and exclusion criteria, a total of 17 studies were eligible in our meta-analysis, involving 1384 Asian patients. The results identified a statistically significant association of high lncRNA expression with poor overall survival [adjusted pooled hazard ratio AHR=1.52; 95% confidence interval (CI): [1.26–1.84], p≤0.001]. The present meta-analysis demonstrated that lncRNA expression might be used as a predictive prognostic biomarker for Asian patients with OSCC. |
| doi_str_mv | 10.1155/2021/6407528 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2617274503</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615860919</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-1867afec555e55d596fa6279337c0c290e1916fe7d1627fccb8950915585e5013</originalsourceid><addsrcrecordid>eNp9kM1LwzAYh4MoOj9uniXgRdC6JG2-vJXhF8xNpuKxxDTVSNvMpEX235u56cGDpze8PPnxex8ADjE6x5jSIUEED1mGOCViAwyw4DQRLEWbYIAIFwkiGdoBuyG8I4SJzOQ22EkzKTjj2QA833v32rrQWQ1nrjbQVXDs2lc4ca12pY2v2SQP0LZw6lUNHz561bg-wJGpazhSXtvWNeoC5vDOdCrJW1Uvgg37YKtSdTAH67kHnq4uH0c3yXh6fTvKx4lOZdolWDCuKqMppYbSkkpWKUa4TFOukSYSGSwxqwwvcVxXWr8ISZGMd4v4AeF0D5yscufeffQmdEVjg47dVGtizYIwzAnPKEojevwHfXe9j32_KSpYzJWROltR2rsQvKmKubeN8osCo2IpvFgKL9bCI360Du1fGlP-wj-GI3C6At5sW6pP-3_cF1mLhHA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615860919</pqid></control><display><type>article</type><title>Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Wang, Yu ; Wang, Peng ; Liu, Xin ; Gao, Ziran ; Cao, Xianbao ; Zhao, Xilong</creator><contributor>Obaid, Ayesha ; Ayesha Obaid</contributor><creatorcontrib>Wang, Yu ; Wang, Peng ; Liu, Xin ; Gao, Ziran ; Cao, Xianbao ; Zhao, Xilong ; Obaid, Ayesha ; Ayesha Obaid</creatorcontrib><description>Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression, and lncRNA expression levels could serve as a potential molecular biomarker for the prognosis and diagnosis of some cancers. However, the prognostic value of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. Thus, a meta-analysis was conducted to explore the potential prognostic value of lncRNAs in OSCC. We systematically searched PubMed, EBSCO, Web of Science, and Elsevier from 2005 to 2021 to identify all published studies that reported the association between lncRNAs and prognosis in OSCC. Then, we used meta-analytic methods to identify the actual effect size of lncRNAs on cancer prognosis. The hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. The reliability of those results was then examined using measures of heterogeneity and testing for selective reporting biases. According to the inclusion and exclusion criteria, a total of 17 studies were eligible in our meta-analysis, involving 1384 Asian patients. The results identified a statistically significant association of high lncRNA expression with poor overall survival [adjusted pooled hazard ratio AHR=1.52; 95% confidence interval (CI): [1.26–1.84], p≤0.001]. The present meta-analysis demonstrated that lncRNA expression might be used as a predictive prognostic biomarker for Asian patients with OSCC.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2021/6407528</identifier><identifier>PMID: 34987674</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Biomarkers ; Cancer ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Cell growth ; Confidence intervals ; Expected values ; Heterogeneity ; Humans ; Identification methods ; Medical prognosis ; Meta-analysis ; Metastasis ; Mouth Neoplasms - genetics ; Mouth Neoplasms - mortality ; Non-coding RNA ; Oral carcinoma ; Oral squamous cell carcinoma ; Prognosis ; Reliability analysis ; Research methodology ; RNA polymerase ; RNA, Long Noncoding - genetics ; Statistical analysis ; Survival Rate ; Tumorigenesis ; Tumors</subject><ispartof>Disease markers, 2021, Vol.2021, p.6407528-9</ispartof><rights>Copyright © 2021 Yu Wang et al.</rights><rights>Copyright © 2021 Yu Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-1867afec555e55d596fa6279337c0c290e1916fe7d1627fccb8950915585e5013</citedby><cites>FETCH-LOGICAL-c393t-1867afec555e55d596fa6279337c0c290e1916fe7d1627fccb8950915585e5013</cites><orcidid>0000-0003-4650-5912 ; 0000-0002-4838-2525 ; 0000-0003-4174-2257 ; 0000-0002-4444-3300 ; 0000-0002-5182-9180 ; 0000-0002-6145-292X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34987674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Obaid, Ayesha</contributor><contributor>Ayesha Obaid</contributor><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Gao, Ziran</creatorcontrib><creatorcontrib>Cao, Xianbao</creatorcontrib><creatorcontrib>Zhao, Xilong</creatorcontrib><title>Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression, and lncRNA expression levels could serve as a potential molecular biomarker for the prognosis and diagnosis of some cancers. However, the prognostic value of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. Thus, a meta-analysis was conducted to explore the potential prognostic value of lncRNAs in OSCC. We systematically searched PubMed, EBSCO, Web of Science, and Elsevier from 2005 to 2021 to identify all published studies that reported the association between lncRNAs and prognosis in OSCC. Then, we used meta-analytic methods to identify the actual effect size of lncRNAs on cancer prognosis. The hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. The reliability of those results was then examined using measures of heterogeneity and testing for selective reporting biases. According to the inclusion and exclusion criteria, a total of 17 studies were eligible in our meta-analysis, involving 1384 Asian patients. The results identified a statistically significant association of high lncRNA expression with poor overall survival [adjusted pooled hazard ratio AHR=1.52; 95% confidence interval (CI): [1.26–1.84], p≤0.001]. The present meta-analysis demonstrated that lncRNA expression might be used as a predictive prognostic biomarker for Asian patients with OSCC.</description><subject>Biomarkers</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Cell growth</subject><subject>Confidence intervals</subject><subject>Expected values</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Identification methods</subject><subject>Medical prognosis</subject><subject>Meta-analysis</subject><subject>Metastasis</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - mortality</subject><subject>Non-coding RNA</subject><subject>Oral carcinoma</subject><subject>Oral squamous cell carcinoma</subject><subject>Prognosis</subject><subject>Reliability analysis</subject><subject>Research methodology</subject><subject>RNA polymerase</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Statistical analysis</subject><subject>Survival Rate</subject><subject>Tumorigenesis</subject><subject>Tumors</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAYh4MoOj9uniXgRdC6JG2-vJXhF8xNpuKxxDTVSNvMpEX235u56cGDpze8PPnxex8ADjE6x5jSIUEED1mGOCViAwyw4DQRLEWbYIAIFwkiGdoBuyG8I4SJzOQ22EkzKTjj2QA833v32rrQWQ1nrjbQVXDs2lc4ca12pY2v2SQP0LZw6lUNHz561bg-wJGpazhSXtvWNeoC5vDOdCrJW1Uvgg37YKtSdTAH67kHnq4uH0c3yXh6fTvKx4lOZdolWDCuKqMppYbSkkpWKUa4TFOukSYSGSwxqwwvcVxXWr8ISZGMd4v4AeF0D5yscufeffQmdEVjg47dVGtizYIwzAnPKEojevwHfXe9j32_KSpYzJWROltR2rsQvKmKubeN8osCo2IpvFgKL9bCI360Du1fGlP-wj-GI3C6At5sW6pP-3_cF1mLhHA</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Wang, Yu</creator><creator>Wang, Peng</creator><creator>Liu, Xin</creator><creator>Gao, Ziran</creator><creator>Cao, Xianbao</creator><creator>Zhao, Xilong</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4650-5912</orcidid><orcidid>https://orcid.org/0000-0002-4838-2525</orcidid><orcidid>https://orcid.org/0000-0003-4174-2257</orcidid><orcidid>https://orcid.org/0000-0002-4444-3300</orcidid><orcidid>https://orcid.org/0000-0002-5182-9180</orcidid><orcidid>https://orcid.org/0000-0002-6145-292X</orcidid></search><sort><creationdate>2021</creationdate><title>Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis</title><author>Wang, Yu ; Wang, Peng ; Liu, Xin ; Gao, Ziran ; Cao, Xianbao ; Zhao, Xilong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-1867afec555e55d596fa6279337c0c290e1916fe7d1627fccb8950915585e5013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Cell growth</topic><topic>Confidence intervals</topic><topic>Expected values</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Identification methods</topic><topic>Medical prognosis</topic><topic>Meta-analysis</topic><topic>Metastasis</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - mortality</topic><topic>Non-coding RNA</topic><topic>Oral carcinoma</topic><topic>Oral squamous cell carcinoma</topic><topic>Prognosis</topic><topic>Reliability analysis</topic><topic>Research methodology</topic><topic>RNA polymerase</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Statistical analysis</topic><topic>Survival Rate</topic><topic>Tumorigenesis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Gao, Ziran</creatorcontrib><creatorcontrib>Cao, Xianbao</creatorcontrib><creatorcontrib>Zhao, Xilong</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu</au><au>Wang, Peng</au><au>Liu, Xin</au><au>Gao, Ziran</au><au>Cao, Xianbao</au><au>Zhao, Xilong</au><au>Obaid, Ayesha</au><au>Ayesha Obaid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>6407528</spage><epage>9</epage><pages>6407528-9</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Long noncoding RNAs (lncRNAs) have emerged as critical regulators of tumor progression, and lncRNA expression levels could serve as a potential molecular biomarker for the prognosis and diagnosis of some cancers. However, the prognostic value of lncRNAs in oral squamous cell carcinoma (OSCC) remains unclear. Thus, a meta-analysis was conducted to explore the potential prognostic value of lncRNAs in OSCC. We systematically searched PubMed, EBSCO, Web of Science, and Elsevier from 2005 to 2021 to identify all published studies that reported the association between lncRNAs and prognosis in OSCC. Then, we used meta-analytic methods to identify the actual effect size of lncRNAs on cancer prognosis. The hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated to assess the strength of the association. The reliability of those results was then examined using measures of heterogeneity and testing for selective reporting biases. According to the inclusion and exclusion criteria, a total of 17 studies were eligible in our meta-analysis, involving 1384 Asian patients. The results identified a statistically significant association of high lncRNA expression with poor overall survival [adjusted pooled hazard ratio AHR=1.52; 95% confidence interval (CI): [1.26–1.84], p≤0.001]. The present meta-analysis demonstrated that lncRNA expression might be used as a predictive prognostic biomarker for Asian patients with OSCC.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34987674</pmid><doi>10.1155/2021/6407528</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4650-5912</orcidid><orcidid>https://orcid.org/0000-0002-4838-2525</orcidid><orcidid>https://orcid.org/0000-0003-4174-2257</orcidid><orcidid>https://orcid.org/0000-0002-4444-3300</orcidid><orcidid>https://orcid.org/0000-0002-5182-9180</orcidid><orcidid>https://orcid.org/0000-0002-6145-292X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-0240 |
| ispartof | Disease markers, 2021, Vol.2021, p.6407528-9 |
| issn | 0278-0240 1875-8630 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2617274503 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Biomarkers Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Cell growth Confidence intervals Expected values Heterogeneity Humans Identification methods Medical prognosis Meta-analysis Metastasis Mouth Neoplasms - genetics Mouth Neoplasms - mortality Non-coding RNA Oral carcinoma Oral squamous cell carcinoma Prognosis Reliability analysis Research methodology RNA polymerase RNA, Long Noncoding - genetics Statistical analysis Survival Rate Tumorigenesis Tumors |
| title | Prognostic Role of Long Noncoding RNAs in Oral Squamous Cell Carcinoma: A Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T08%3A52%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Role%20of%20Long%20Noncoding%20RNAs%20in%20Oral%20Squamous%20Cell%20Carcinoma:%20A%20Meta-Analysis&rft.jtitle=Disease%20markers&rft.au=Wang,%20Yu&rft.date=2021&rft.volume=2021&rft.spage=6407528&rft.epage=9&rft.pages=6407528-9&rft.issn=0278-0240&rft.eissn=1875-8630&rft_id=info:doi/10.1155/2021/6407528&rft_dat=%3Cproquest_cross%3E2615860919%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2615860919&rft_id=info:pmid/34987674&rfr_iscdi=true |