AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

AMP-activated protein kinase (AMPK) regulates the balance between cellular anabolism and catabolism dependent on energy resources to maintain proliferation and survival. Small-compound AMPK activators show anti-cancer activity in preclinical models. Using the direct AMPK activator GSK621, we show th...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-01, Vol.38 (1), p.110197-110197, Article 110197
Hauptverfasser:	Grenier, Adrien, Poulain, Laury, Mondesir, Johanna, Jacquel, Arnaud, Bosc, Claudie, Stuani, Lucille, Mouche, Sarah, Larrue, Clement, Sahal, Ambrine, Birsen, Rudy, Ghesquier, Victoria, Decroocq, Justine, Mazed, Fetta, Lambert, Mireille, Andrianteranagna, Mamy, Viollet, Benoit, Auberger, Patrick, Lane, Andrew A, Sujobert, Pierre, Bouscary, Didier, Sarry, Jean-Emmanuel, Tamburini, Jerome
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over AMP-Activated Protein Kinases - metabolism Animals Antineoplastic Agents - pharmacology Apoptosis - physiology Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line, Tumor Citric Acid Cycle - drug effects Drug Evaluation, Preclinical eIF-2 Kinase - metabolism Female HEK293 Cells HL-60 Cells Humans Imidazoles - pharmacology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Male Mice Middle Aged Mitochondria - metabolism Oxidative Phosphorylation - drug effects Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Pyrimidinones - pharmacology Sulfonamides - pharmacology THP-1 Cells U937 Cells Unfolded Protein Response - physiology Young Adult
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