Perfluorooctane sulfonate aggravates CCl4‐induced hepatic fibrosis via HMGB1/TLR4/Smad signaling

Perfluorooctane sulfonate (PFOS) is a widespread environmental pollutant and may cause a variety of adverse health effects. The hepatotoxicity of PFOS has attracted particular attention, given the fact that the liver has one of the highest PFOS accumulations among human tissues. In this study, we re...

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Veröffentlicht in:	Environmental toxicology 2022-05, Vol.37 (5), p.983-994
Hauptverfasser:	Wan, Chunhua, Gu, Tianye, Ling, Junyi, Qin, Yi, Luo, Jiashan, Sun, Lingli, Hua, Lu, Zhao, Jianya, Jiang, Shengyang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - toxicity Animal models Animals Bioaccumulation Calcium Calcium signalling Carbon tetrachloride Cell activation Cytoplasm Exposure Fibrosis Fluorocarbons - toxicity Health risks Hepatic Stellate Cells Hepatocytes Hepatotoxicity HMGB1 HMGB1 protein HMGB1 Protein - metabolism Human tissues Liver Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism liver fibrosis Perfluorooctane sulfonic acid PFOS Pollutants Secretion Signal Transduction Signaling Smad protein Smad2 protein Sulfonates TLR4 TLR4 protein Toll-Like Receptor 4 - metabolism Toll-like receptors Translocation
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