AM22, a novel synthetic microRNA, inhibits the proliferation of colorectal cancer cells by targeting core binding factor subunit β (CBFB)

Summary Our previous studies have revealed the important roles of the nonseed regions of microRNAs (miRNAs) in gene regulation, which provided novel insight into the development of miRNA analogs for cancer therapy. Here, we altered each nucleotide in the nonseed region of miR-34a and obtained novel...

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Veröffentlicht in:	Investigational new drugs 2022-06, Vol.40 (3), p.469-477
Hauptverfasser:	Meng, Fanyi, Li, Jiawei, Qiu, Yajing, Zhang, Haiyang, Zhang, Hongjian, Wang, Weipeng
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Analogs Animal models Animals Antiproliferatives Binding Cancer Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Core Binding Factor beta Subunit - genetics Core Binding Factor beta Subunit - metabolism Gene Expression Regulation, Neoplastic Gene regulation Humans Medicine Medicine & Public Health Mice MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Nucleotides Oncology Pharmacology/Toxicology Preclinical Studies Ribonucleic acid RNA Tumor cell lines Tumors Xenografts Xenotransplantation
Online-Zugang:	Volltext
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