Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia–reperfusion injury
Renal ischemia–reperfusion (IR) produces-induced injury and is characterized by restriction of blood supply to the kidney followed by restoration and re-oxygenation of the tissue. IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion inju...
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Veröffentlicht in: | Molecular and cellular biochemistry 2022-02, Vol.477 (2), p.627-634 |
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description | Renal ischemia–reperfusion (IR) produces-induced injury and is characterized by restriction of blood supply to the kidney followed by restoration and re-oxygenation of the tissue. IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. Protein fractions can serve as an important predictive marker for the prognosis and duration of acute inflammation. Serum globulin levels and the A/G ratio may serve as effective prognostic markers in acute inflammation caused by ischemia–reperfusion injury of the kidney. A strong correlation between globulin and the A/G ratio suggests novel markers associated with acute inflammation that can lead to chronic kidney disease. |
doi_str_mv | 10.1007/s11010-021-04322-y |
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IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. Protein fractions can serve as an important predictive marker for the prognosis and duration of acute inflammation. Serum globulin levels and the A/G ratio may serve as effective prognostic markers in acute inflammation caused by ischemia–reperfusion injury of the kidney. A strong correlation between globulin and the A/G ratio suggests novel markers associated with acute inflammation that can lead to chronic kidney disease.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-021-04322-y</identifier><identifier>PMID: 34984594</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acute Disease ; Animal models ; Animals ; Antithrombin ; Antithrombin III - pharmacology ; Biochemistry ; Biomedical and Life Sciences ; Blood proteins ; Cardiology ; Chronic kidney failure ; Disease Models, Animal ; G ratio ; Globulins ; Inflammation ; Injuries ; Ischemia ; Kidney diseases ; Kidney Diseases - metabolism ; Kidney Diseases - pathology ; Kidney Diseases - prevention & control ; Kidneys ; Life Sciences ; Markers ; Medical Biochemistry ; Oncology ; Oxygenation ; Perfusion ; Physiological aspects ; Physiological effects ; Proteins ; Rats ; Rats, Wistar ; Renal artery ; Reperfusion ; Reperfusion injury ; Reperfusion Injury - metabolism ; Reperfusion Injury - pathology ; Reperfusion Injury - prevention & control ; Serum proteins</subject><ispartof>Molecular and cellular biochemistry, 2022-02, Vol.477 (2), p.627-634</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>2021. 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IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. Protein fractions can serve as an important predictive marker for the prognosis and duration of acute inflammation. Serum globulin levels and the A/G ratio may serve as effective prognostic markers in acute inflammation caused by ischemia–reperfusion injury of the kidney. A strong correlation between globulin and the A/G ratio suggests novel markers associated with acute inflammation that can lead to chronic kidney disease.</description><subject>Acute Disease</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antithrombin</subject><subject>Antithrombin III - pharmacology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Blood proteins</subject><subject>Cardiology</subject><subject>Chronic kidney failure</subject><subject>Disease Models, Animal</subject><subject>G ratio</subject><subject>Globulins</subject><subject>Inflammation</subject><subject>Injuries</subject><subject>Ischemia</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Markers</subject><subject>Medical Biochemistry</subject><subject>Oncology</subject><subject>Oxygenation</subject><subject>Perfusion</subject><subject>Physiological aspects</subject><subject>Physiological effects</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal artery</subject><subject>Reperfusion</subject><subject>Reperfusion injury</subject><subject>Reperfusion Injury - 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pharmacology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Blood proteins</topic><topic>Cardiology</topic><topic>Chronic kidney failure</topic><topic>Disease Models, Animal</topic><topic>G ratio</topic><topic>Globulins</topic><topic>Inflammation</topic><topic>Injuries</topic><topic>Ischemia</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Markers</topic><topic>Medical Biochemistry</topic><topic>Oncology</topic><topic>Oxygenation</topic><topic>Perfusion</topic><topic>Physiological aspects</topic><topic>Physiological effects</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal artery</topic><topic>Reperfusion</topic><topic>Reperfusion injury</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - pathology</topic><topic>Reperfusion Injury - 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Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Firdus, Alena</au><au>Avdagić, Nesina</au><au>Fočak, Muhamed</au><au>Mitrašinović-Brulić, Maja</au><au>Suljević, Damir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia–reperfusion injury</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>477</volume><issue>2</issue><spage>627</spage><epage>634</epage><pages>627-634</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Renal ischemia–reperfusion (IR) produces-induced injury and is characterized by restriction of blood supply to the kidney followed by restoration and re-oxygenation of the tissue. IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. Protein fractions can serve as an important predictive marker for the prognosis and duration of acute inflammation. Serum globulin levels and the A/G ratio may serve as effective prognostic markers in acute inflammation caused by ischemia–reperfusion injury of the kidney. A strong correlation between globulin and the A/G ratio suggests novel markers associated with acute inflammation that can lead to chronic kidney disease.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34984594</pmid><doi>10.1007/s11010-021-04322-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4089-3037</orcidid><orcidid>https://orcid.org/0000-0002-9378-681X</orcidid><orcidid>https://orcid.org/0000-0002-1281-1527</orcidid><orcidid>https://orcid.org/0000-0001-6398-5677</orcidid><orcidid>https://orcid.org/0000-0002-8854-7478</orcidid></addata></record> |
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subjects | Acute Disease Animal models Animals Antithrombin Antithrombin III - pharmacology Biochemistry Biomedical and Life Sciences Blood proteins Cardiology Chronic kidney failure Disease Models, Animal G ratio Globulins Inflammation Injuries Ischemia Kidney diseases Kidney Diseases - metabolism Kidney Diseases - pathology Kidney Diseases - prevention & control Kidneys Life Sciences Markers Medical Biochemistry Oncology Oxygenation Perfusion Physiological aspects Physiological effects Proteins Rats Rats, Wistar Renal artery Reperfusion Reperfusion injury Reperfusion Injury - metabolism Reperfusion Injury - pathology Reperfusion Injury - prevention & control Serum proteins |
title | Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia–reperfusion injury |
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