Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia–reperfusion injury

Renal ischemia–reperfusion (IR) produces-induced injury and is characterized by restriction of blood supply to the kidney followed by restoration and re-oxygenation of the tissue. IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion inju...

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Veröffentlicht in:Molecular and cellular biochemistry 2022-02, Vol.477 (2), p.627-634
Hauptverfasser: Firdus, Alena, Avdagić, Nesina, Fočak, Muhamed, Mitrašinović-Brulić, Maja, Suljević, Damir
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container_title Molecular and cellular biochemistry
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creator Firdus, Alena
Avdagić, Nesina
Fočak, Muhamed
Mitrašinović-Brulić, Maja
Suljević, Damir
description Renal ischemia–reperfusion (IR) produces-induced injury and is characterized by restriction of blood supply to the kidney followed by restoration and re-oxygenation of the tissue. IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. Protein fractions can serve as an important predictive marker for the prognosis and duration of acute inflammation. Serum globulin levels and the A/G ratio may serve as effective prognostic markers in acute inflammation caused by ischemia–reperfusion injury of the kidney. A strong correlation between globulin and the A/G ratio suggests novel markers associated with acute inflammation that can lead to chronic kidney disease.
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IR injury in the kidney contributes to pathological processes known as acute renal injury (ARI). Ischemia-perfusion injury (IRI) of the left renal artery has been demonstrated in Wistar rats. A total of 32 animals were divided into four groups: control group (SHAM), IR animals with induced ischemia–reperfusion, AT-IR animals treated by antithrombin III (AT) before IR, and AT-IR-AT animals with AT administered before and after IR. IR-induced hyperproteinemia, hyperalbuminemia, hyperglobulinemia, and a significantly low A/G ratio. Exogenous administration of AT prior to IR development effectively regulates protein fraction levels by establishing normoproteinemia. The preventive effect of AT regulates serum protein levels and reduces acute inflammation by reducing globulin and establishing physiological levels of A/G ratios. The therapeutic effect of AT given after IR is not effective compared to AT administered before IR. 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subjects Acute Disease
Animal models
Animals
Antithrombin
Antithrombin III - pharmacology
Biochemistry
Biomedical and Life Sciences
Blood proteins
Cardiology
Chronic kidney failure
Disease Models, Animal
G ratio
Globulins
Inflammation
Injuries
Ischemia
Kidney diseases
Kidney Diseases - metabolism
Kidney Diseases - pathology
Kidney Diseases - prevention & control
Kidneys
Life Sciences
Markers
Medical Biochemistry
Oncology
Oxygenation
Perfusion
Physiological aspects
Physiological effects
Proteins
Rats
Rats, Wistar
Renal artery
Reperfusion
Reperfusion injury
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Reperfusion Injury - prevention & control
Serum proteins
title Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia–reperfusion injury
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