Multi-Excitation Raman Spectroscopy for Label-Free, Strain-Level Characterization of Bacterial Pathogens in Artificial Sputum Media

The current methods for diagnosis of acute and chronic infections are complex and skill-intensive. For complex clinical biofilm infections, it can take days from collecting and processing a patient’s sample to achieving a result. These aspects place a significant burden on healthcare providers, dela...

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Veröffentlicht in:	Analytical chemistry (Washington) 2022-01, Vol.94 (2), p.669-677
Hauptverfasser:	Lister, Adam P, Highmore, Callum J, Hanrahan, Niall, Read, James, Munro, Alasdair P. S, Tan, Samuel, Allan, Raymond N, Faust, Saul N, Webb, Jeremy S, Mahajan, Sumeet
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Bacteria Biofilms Carotenoids Chemistry Cystic fibrosis Diagnosis Drug resistance Excitation spectra Infections Medical personnel Methicillin-Resistant Staphylococcus aureus Microorganisms Multivariate analysis Pathogens Patients Porphyrins Pseudomonas aeruginosa Raman spectra Raman spectroscopy Respiratory diseases Spectroscopy Spectrum analysis Spectrum Analysis, Raman - methods Sputum Sputum - microbiology Staphylococcus aureus Staphylococcus aureus - chemistry Support vector machines Wavelengths
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