Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice

Dynamic miRNA alteration is known to occur in colitis-associated colon cancer (CAC), while the molecular mechanisms underpinning how miRNAs modulate the development from chronic inflammation to CAC is lacking. For the first time, we constructed knockout (KO) mice for individual miR-148/152 family me...

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Veröffentlicht in:	Cancer letters 2022-03, Vol.529, p.53-69
Hauptverfasser:	Tang, Kaiwen, Wu, Zhonghua, Sun, Mingwei, Huang, Xuanzhang, Sun, Jingxu, Shi, Jinxin, Wang, Xin, Miao, Zhifeng, Gao, Peng, Song, Yongxi, Wang, Zhenning
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Carcinogenesis - genetics Carcinogenesis - metabolism Cell Line, Tumor Colitis Colitis - etiology Colitis-associated colon cancer Collagenase 3 Colon cancer Colonic Neoplasms - etiology Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Disease Disease Models, Animal Disease Progression Drinking water Fluorescent Antibody Technique Gene expression Gene Knockdown Techniques Homeostasis Humans Immunohistochemistry Inflammatory bowel disease Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Laboratory animals Matrix Metalloproteinase 10 - genetics Matrix Metalloproteinase 10 - metabolism Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Mice Mice, Knockout MicroRNAs - genetics MicroRNAs - metabolism miRNA miRNAs Molecular modelling NF-kappa B - metabolism NF-κB protein Pathogens Proteins Reagents Signal Transduction Stromelysin 2 Tumor necrosis factor-α Tumorigenesis
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