Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases
It is considered a significant challenge to understand the neuronal cell death mechanisms with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one of the best-considered “cysteine proteases activated” in brain disorders. Calpain is an important marker and mediator i...
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| Veröffentlicht in: | Neurochemical research 2022-05, Vol.47 (5), p.1125-1149 |
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| container_title | Neurochemical research |
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| creator | Khan, Heena Garg, Nikhil Singh, Thakur Gurjeet Kaur, Amarjot Thapa, Komal |
| description | It is considered a significant challenge to understand the neuronal cell death mechanisms with a suitable cure for neurodegenerative disorders in the coming years. Calpains are one of the best-considered “cysteine proteases activated” in brain disorders. Calpain is an important marker and mediator in the pathophysiology of neurodegeneration. Calpain activation being the essential neurodegenerative factor causing apoptotic machinery activation, it is crucial to develop reliable and effective approaches to prevent calpain-mediated apoptosis in degenerating neurons. It has been recently seen that the “inhibition of calpain activation” has appeared as a possible therapeutic target for managing neurodegenerative diseases. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was conducted. The present article reviews the basic pathobiology and role of selective calpain inhibitors used in various neurodegenerative diseases as a therapeutic target.
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| doi_str_mv | 10.1007/s11064-021-03521-9 |
| format | Article |
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Calpains are one of the best-considered “cysteine proteases activated” in brain disorders. Calpain is an important marker and mediator in the pathophysiology of neurodegeneration. Calpain activation being the essential neurodegenerative factor causing apoptotic machinery activation, it is crucial to develop reliable and effective approaches to prevent calpain-mediated apoptosis in degenerating neurons. It has been recently seen that the “inhibition of calpain activation” has appeared as a possible therapeutic target for managing neurodegenerative diseases. A systematic literature review of PubMed, Medline, Bentham, Scopus, and EMBASE (Elsevier) databases was conducted. The present article reviews the basic pathobiology and role of selective calpain inhibitors used in various neurodegenerative diseases as a therapeutic target.
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| subjects | Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Calpain Calpain - physiology Cell Biology Cell death Humans Inhibitors Literature reviews Modulators Neurochemistry Neurodegeneration Neurodegenerative diseases Neurodegenerative Diseases - drug therapy Neurology Neuromodulation Neurosciences Pathophysiology Review Therapeutic applications Therapeutic targets |
| title | Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases |
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