Multiple Myeloma-Derived Extracellular Vesicles Impair Normal Hematopoiesis by Acting on Hematopoietic Stem and Progenitor Cells

Multiple myeloma (MM) is characterized by the abnormal proliferation of clonal plasma cells (PCs) in bone marrow (BM). MM-PCs progressively occupy and likely alter BM niches where reside hematopoietic stem and progenitor cells (HSPCs) whose viability, self-renewal, proliferation, commitment, and dif...

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Veröffentlicht in:	Frontiers in medicine 2021-12, Vol.8, p.793040-793040, Article 793040
Hauptverfasser:	Laurenzana, Ilaria, Trino, Stefania, Lamorte, Daniela, De Stradis, Angelo, Santodirocco, Michele, Sgambato, Alessandro, De Luca, Luciana, Caivano, Antonella
Format:	Artikel
Sprache:	eng
Schlagworte:	differentiation extracellular vesicles General & Internal Medicine hematopoiesis hematopoietic stem and progenitor cells Life Sciences & Biomedicine Medicine Medicine, General & Internal microRNA multiple myeloma Science & Technology
Online-Zugang:	Volltext
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