Self-assembled chitosan derived microparticles inhibit tumor angiogenesis and induce apoptosis in Ehrlich-ascites-tumor bearing mice

Self-assembled microparticles from chitosan (SAMC) was prepared by depolymerization induced by potassium persulfate. Particle size distribution data showed averaged around 5 μm size and SEM indicated the sequential formation of “RBC” shaped particles. Soluble SAMC consists of ‘deacetylated’ residues...

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Veröffentlicht in:	Carbohydrate polymers 2022-02, Vol.278, p.118941-118941, Article 118941
Hauptverfasser:	Punarvasu, T.P., Prashanth, K.V. Harish
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Apoptosis Apoptosis - drug effects Carbohydrate Conformation Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Ehrlich Tumor - metabolism Carcinoma, Ehrlich Tumor - pathology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Chitosan Chitosan - chemical synthesis Chitosan - chemistry Chitosan - pharmacology Cytotoxicity Drug Screening Assays, Antitumor Ehrlich ascites tumor Female Humans Mice Microparticles Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology
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