Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer
Purpose Gastric cancer (GC) has been identified worldwide as one of the most common cancer types with a high mortality rate. LncRNA SDMGC has been recognized as an oncogene with regulatory effects on its target gene, TRIM16, which is believed to play a tumor-suppressing role in various cancers. Both...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2023-03, Vol.54 (1), p.44-50 |
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| creator | Seifi Inallou, Mina Safaralizadeh, Reza Rajabi, Ali Hosseinpourfeizi, Mohammadali Haghi, Mehdi |
| description | Purpose
Gastric cancer (GC) has been identified worldwide as one of the most common cancer types with a high mortality rate. LncRNA SDMGC has been recognized as an oncogene with regulatory effects on its target gene, TRIM16, which is believed to play a tumor-suppressing role in various cancers. Both these genes are involved in GC development, tumorigenesis, invasion, and metastasis. The current study is aimed to investigate the association of SDMGC and TRIM16 with GC susceptibility and GC patients’ clinicopathological characteristics.
Methods
A total of 100 GC tissues and their corresponding adjacent non-tumor tissues were sampled. Total RNA was then isolated to measure SDMGC and TRIM16 expression levels using quantitative reverse transcriptase (qRT)-PCR. Statistical analyses including the Mann–Whitney
U
test and correlation tests were carried out using R v4.5. GraphPad Prism was also used to plot the receiver operating curve (ROC).
Results
The results demonstrated the significant overexpression of lncRNAs SDMGC and downregulation of TRIM16 in GC tissues as compared to their corresponding marginal normal tissue samples (
P
= 0.005 and
P
= 0.009, respectively). No association with clinicopathological variables was observed for either SDMGC or TRIM16. Moreover, the results demonstrated a small positive correlation between SDMGC and TRIM16. Evaluation of the diagnostic value of SDMGC and TRIM16 showed poor biomarker potency for these genes.
Conclusion
In conclusion, the results indicated an increase in the expression of SDMGC and a decline in the expression pattern of TRIM16 among the Iranian population. The results indicated a key tumor-accelerative function of SDMGC and a pivotal tumor-suppressing role of TRIM16 in GC patients. |
| doi_str_mv | 10.1007/s12029-021-00791-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2616288048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2616288048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-e5f5fe3a8e51d2048abff175d02a272a58202f99e0fcfd54e79aafd8e1e78cba3</originalsourceid><addsrcrecordid>eNp9kE1PAjEQhhujEUT_gAfTowdW2-73kay4kgAaxHNTdqewBFpsd6P8e4uLHD3NTOaZN5kHoVtKHigh8aOljLDUI4x6bkyptz9DXZoG1IsiPzo_9SzpoCtr14REQUjpJer4QRonDuoim62EWoLFlcL1CvDwe2fA2korrCUea7XEU628TJeVa2fTAX5_muQZFqrEo9riuTBLqHEOCvp4PhtNaNQ_ZL2JugLlgK-qXuFc2NpUBc6EKsBcowspNhZujrWHPp6H8-zFG7_mo2ww9go_iGsPQhlK8EUCIS0ZCRKxkJLGYUmYYDETYeLel2kKRBayDAOIUyFkmQCFOCkWwu-h-zZ3Z_RnA7bm28oWsNkIBbqxnEXUuUlcskNZixZGW2tA8p2ptsLsOSX8IJu3srmTzX9l8707ujvmN4stlKeTP7sO8FvAupWzbPhaN0a5n_-L_QHJ9Yl_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2616288048</pqid></control><display><type>article</type><title>Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Seifi Inallou, Mina ; Safaralizadeh, Reza ; Rajabi, Ali ; Hosseinpourfeizi, Mohammadali ; Haghi, Mehdi</creator><creatorcontrib>Seifi Inallou, Mina ; Safaralizadeh, Reza ; Rajabi, Ali ; Hosseinpourfeizi, Mohammadali ; Haghi, Mehdi</creatorcontrib><description>Purpose
Gastric cancer (GC) has been identified worldwide as one of the most common cancer types with a high mortality rate. LncRNA SDMGC has been recognized as an oncogene with regulatory effects on its target gene, TRIM16, which is believed to play a tumor-suppressing role in various cancers. Both these genes are involved in GC development, tumorigenesis, invasion, and metastasis. The current study is aimed to investigate the association of SDMGC and TRIM16 with GC susceptibility and GC patients’ clinicopathological characteristics.
Methods
A total of 100 GC tissues and their corresponding adjacent non-tumor tissues were sampled. Total RNA was then isolated to measure SDMGC and TRIM16 expression levels using quantitative reverse transcriptase (qRT)-PCR. Statistical analyses including the Mann–Whitney
U
test and correlation tests were carried out using R v4.5. GraphPad Prism was also used to plot the receiver operating curve (ROC).
Results
The results demonstrated the significant overexpression of lncRNAs SDMGC and downregulation of TRIM16 in GC tissues as compared to their corresponding marginal normal tissue samples (
P
= 0.005 and
P
= 0.009, respectively). No association with clinicopathological variables was observed for either SDMGC or TRIM16. Moreover, the results demonstrated a small positive correlation between SDMGC and TRIM16. Evaluation of the diagnostic value of SDMGC and TRIM16 showed poor biomarker potency for these genes.
Conclusion
In conclusion, the results indicated an increase in the expression of SDMGC and a decline in the expression pattern of TRIM16 among the Iranian population. The results indicated a key tumor-accelerative function of SDMGC and a pivotal tumor-suppressing role of TRIM16 in GC patients.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-021-00791-y</identifier><identifier>PMID: 34978663</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Cell Line, Tumor ; Gastroenterology ; Gene Expression Regulation, Neoplastic ; Humans ; Internal Medicine ; Iran ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Prognosis ; Radiotherapy ; RNA, Long Noncoding - metabolism ; Stomach Neoplasms - pathology ; Tripartite Motif Proteins - genetics ; Tripartite Motif Proteins - metabolism ; Ubiquitin-Protein Ligases - genetics ; Ubiquitin-Protein Ligases - metabolism</subject><ispartof>Journal of gastrointestinal cancer, 2023-03, Vol.54 (1), p.44-50</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-e5f5fe3a8e51d2048abff175d02a272a58202f99e0fcfd54e79aafd8e1e78cba3</citedby><cites>FETCH-LOGICAL-c347t-e5f5fe3a8e51d2048abff175d02a272a58202f99e0fcfd54e79aafd8e1e78cba3</cites><orcidid>0000-0002-6970-6998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-021-00791-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-021-00791-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34978663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seifi Inallou, Mina</creatorcontrib><creatorcontrib>Safaralizadeh, Reza</creatorcontrib><creatorcontrib>Rajabi, Ali</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammadali</creatorcontrib><creatorcontrib>Haghi, Mehdi</creatorcontrib><title>Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Purpose
Gastric cancer (GC) has been identified worldwide as one of the most common cancer types with a high mortality rate. LncRNA SDMGC has been recognized as an oncogene with regulatory effects on its target gene, TRIM16, which is believed to play a tumor-suppressing role in various cancers. Both these genes are involved in GC development, tumorigenesis, invasion, and metastasis. The current study is aimed to investigate the association of SDMGC and TRIM16 with GC susceptibility and GC patients’ clinicopathological characteristics.
Methods
A total of 100 GC tissues and their corresponding adjacent non-tumor tissues were sampled. Total RNA was then isolated to measure SDMGC and TRIM16 expression levels using quantitative reverse transcriptase (qRT)-PCR. Statistical analyses including the Mann–Whitney
U
test and correlation tests were carried out using R v4.5. GraphPad Prism was also used to plot the receiver operating curve (ROC).
Results
The results demonstrated the significant overexpression of lncRNAs SDMGC and downregulation of TRIM16 in GC tissues as compared to their corresponding marginal normal tissue samples (
P
= 0.005 and
P
= 0.009, respectively). No association with clinicopathological variables was observed for either SDMGC or TRIM16. Moreover, the results demonstrated a small positive correlation between SDMGC and TRIM16. Evaluation of the diagnostic value of SDMGC and TRIM16 showed poor biomarker potency for these genes.
Conclusion
In conclusion, the results indicated an increase in the expression of SDMGC and a decline in the expression pattern of TRIM16 among the Iranian population. The results indicated a key tumor-accelerative function of SDMGC and a pivotal tumor-suppressing role of TRIM16 in GC patients.</description><subject>Cancer Research</subject><subject>Cell Line, Tumor</subject><subject>Gastroenterology</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Iran</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Tripartite Motif Proteins - genetics</subject><subject>Tripartite Motif Proteins - metabolism</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><subject>Ubiquitin-Protein Ligases - metabolism</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAjEQhhujEUT_gAfTowdW2-73kay4kgAaxHNTdqewBFpsd6P8e4uLHD3NTOaZN5kHoVtKHigh8aOljLDUI4x6bkyptz9DXZoG1IsiPzo_9SzpoCtr14REQUjpJer4QRonDuoim62EWoLFlcL1CvDwe2fA2korrCUea7XEU628TJeVa2fTAX5_muQZFqrEo9riuTBLqHEOCvp4PhtNaNQ_ZL2JugLlgK-qXuFc2NpUBc6EKsBcowspNhZujrWHPp6H8-zFG7_mo2ww9go_iGsPQhlK8EUCIS0ZCRKxkJLGYUmYYDETYeLel2kKRBayDAOIUyFkmQCFOCkWwu-h-zZ3Z_RnA7bm28oWsNkIBbqxnEXUuUlcskNZixZGW2tA8p2ptsLsOSX8IJu3srmTzX9l8707ujvmN4stlKeTP7sO8FvAupWzbPhaN0a5n_-L_QHJ9Yl_</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Seifi Inallou, Mina</creator><creator>Safaralizadeh, Reza</creator><creator>Rajabi, Ali</creator><creator>Hosseinpourfeizi, Mohammadali</creator><creator>Haghi, Mehdi</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6970-6998</orcidid></search><sort><creationdate>20230301</creationdate><title>Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer</title><author>Seifi Inallou, Mina ; Safaralizadeh, Reza ; Rajabi, Ali ; Hosseinpourfeizi, Mohammadali ; Haghi, Mehdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-e5f5fe3a8e51d2048abff175d02a272a58202f99e0fcfd54e79aafd8e1e78cba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer Research</topic><topic>Cell Line, Tumor</topic><topic>Gastroenterology</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Iran</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Tripartite Motif Proteins - genetics</topic><topic>Tripartite Motif Proteins - metabolism</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><topic>Ubiquitin-Protein Ligases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seifi Inallou, Mina</creatorcontrib><creatorcontrib>Safaralizadeh, Reza</creatorcontrib><creatorcontrib>Rajabi, Ali</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammadali</creatorcontrib><creatorcontrib>Haghi, Mehdi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seifi Inallou, Mina</au><au>Safaralizadeh, Reza</au><au>Rajabi, Ali</au><au>Hosseinpourfeizi, Mohammadali</au><au>Haghi, Mehdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>54</volume><issue>1</issue><spage>44</spage><epage>50</epage><pages>44-50</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Purpose
Gastric cancer (GC) has been identified worldwide as one of the most common cancer types with a high mortality rate. LncRNA SDMGC has been recognized as an oncogene with regulatory effects on its target gene, TRIM16, which is believed to play a tumor-suppressing role in various cancers. Both these genes are involved in GC development, tumorigenesis, invasion, and metastasis. The current study is aimed to investigate the association of SDMGC and TRIM16 with GC susceptibility and GC patients’ clinicopathological characteristics.
Methods
A total of 100 GC tissues and their corresponding adjacent non-tumor tissues were sampled. Total RNA was then isolated to measure SDMGC and TRIM16 expression levels using quantitative reverse transcriptase (qRT)-PCR. Statistical analyses including the Mann–Whitney
U
test and correlation tests were carried out using R v4.5. GraphPad Prism was also used to plot the receiver operating curve (ROC).
Results
The results demonstrated the significant overexpression of lncRNAs SDMGC and downregulation of TRIM16 in GC tissues as compared to their corresponding marginal normal tissue samples (
P
= 0.005 and
P
= 0.009, respectively). No association with clinicopathological variables was observed for either SDMGC or TRIM16. Moreover, the results demonstrated a small positive correlation between SDMGC and TRIM16. Evaluation of the diagnostic value of SDMGC and TRIM16 showed poor biomarker potency for these genes.
Conclusion
In conclusion, the results indicated an increase in the expression of SDMGC and a decline in the expression pattern of TRIM16 among the Iranian population. The results indicated a key tumor-accelerative function of SDMGC and a pivotal tumor-suppressing role of TRIM16 in GC patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34978663</pmid><doi>10.1007/s12029-021-00791-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6970-6998</orcidid></addata></record> |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Cancer Research Cell Line, Tumor Gastroenterology Gene Expression Regulation, Neoplastic Humans Internal Medicine Iran Medicine Medicine & Public Health Oncology Original Research Prognosis Radiotherapy RNA, Long Noncoding - metabolism Stomach Neoplasms - pathology Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism |
| title | Changes in the Expression of Long Non-Coding RNA SDMGC and Its Target Gene, TRIM16, in Patients with Gastric Cancer |
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