Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens

Objective To evaluate the effects of repeated sprint (RS) training in hypoxia on aerobic performance, repeated sprint ability (RSA), and muscle oxygenation in Rugby Sevens. Methods Fourteen Rugby Sevens players were randomly allocated into hypoxic (RSH, F I O 2  = 14.5%, n  = 7) or normoxic (RSN, F...

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Veröffentlicht in:European journal of applied physiology 2022-03, Vol.122 (3), p.611-622
Hauptverfasser: Pramkratok, Wadee, Songsupap, Tongthong, Yimlamai, Tossaporn
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description Objective To evaluate the effects of repeated sprint (RS) training in hypoxia on aerobic performance, repeated sprint ability (RSA), and muscle oxygenation in Rugby Sevens. Methods Fourteen Rugby Sevens players were randomly allocated into hypoxic (RSH, F I O 2  = 14.5%, n  = 7) or normoxic (RSN, F I O 2  = 20.9%, n  = 7) groups. Both groups underwent RS training consisting of 3 sets of 6-s × 10 sprints at 140% of velocity at peak oxygen uptake ( v V O 2 peak ) on a motorized treadmill, 3 days/week for 6 weeks in addition to usual training. Hematological variables, hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) concentrations were measured. Aerobic performance, RSA, and muscle oxygenation during the running-based anaerobic sprint (RAS) test were analyzed. Results RSH caused no changes in hemoglobin concentration and hematocrit but significant improvements in V O 2 peak (7.5%, p  = 0.03, ES = 1.07), time to exhaustion (17.6%, p  = 0.05, ES = 0.92), and fatigue index (FI, − 12.3%, p  = 0.01, ES = 1.39) during the RSA test compared to baseline but not RSN. While ∆deoxygenated hemoglobin was significantly increased both after RSH and RSN ( p  
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Methods Fourteen Rugby Sevens players were randomly allocated into hypoxic (RSH, F I O 2  = 14.5%, n  = 7) or normoxic (RSN, F I O 2  = 20.9%, n  = 7) groups. Both groups underwent RS training consisting of 3 sets of 6-s × 10 sprints at 140% of velocity at peak oxygen uptake ( v V O 2 peak ) on a motorized treadmill, 3 days/week for 6 weeks in addition to usual training. Hematological variables, hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) concentrations were measured. Aerobic performance, RSA, and muscle oxygenation during the running-based anaerobic sprint (RAS) test were analyzed. Results RSH caused no changes in hemoglobin concentration and hematocrit but significant improvements in V O 2 peak (7.5%, p  = 0.03, ES = 1.07), time to exhaustion (17.6%, p  = 0.05, ES = 0.92), and fatigue index (FI, − 12.3%, p  = 0.01, ES = 1.39) during the RSA test compared to baseline but not RSN. While ∆deoxygenated hemoglobin was significantly increased both after RSH and RSN ( p  &lt; 0.05), ∆tissue saturation index (− 56.1%, p  = 0.01, ES = 1.35) and ∆oxygenated hemoglobin (− 54.7%, p  = 0.04, ES = 0.97) were significantly decreased after RSH. These changes were concomitant with increased levels of HIF-1α and VEGF in serum after RSH with a strong negative correlation between ∆FI and ∆deoxygenated hemoglobin after RSH ( r  = − 0.81, p  = 0.03). Conclusion There was minimal benefit from adding RSH to standard Rugby Sevens training, in eliciting improvements in aerobic performance and resistance to fatigue, possibly by enhanced muscle deoxygenation and increased serum HIF-1α and VEGF concentrations.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-021-04861-8</identifier><identifier>PMID: 34977961</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Angiogenesis ; Athletic Performance - physiology ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Fatigue ; Hematocrit ; Hemoglobin ; Human Physiology ; Humans ; Hypoxia ; Hypoxia-inducible factor 1 ; Hypoxia-Inducible Factor 1, alpha Subunit - blood ; Hypoxia-inducible factor 1a ; Male ; Muscle, Skeletal - metabolism ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen Consumption - physiology ; Oxygenation ; Physical Conditioning, Human ; Rugby ; Rugby - physiology ; Running - physiology ; Sports Medicine ; Thailand ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - blood ; Young Adult</subject><ispartof>European journal of applied physiology, 2022-03, Vol.122 (3), p.611-622</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a2654d040d05bd6d1313567e55dad4912d2c5b7582849bbdd9f249d003bfe3f93</citedby><cites>FETCH-LOGICAL-c375t-a2654d040d05bd6d1313567e55dad4912d2c5b7582849bbdd9f249d003bfe3f93</cites><orcidid>0000-0003-0861-7075</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-021-04861-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-021-04861-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34977961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pramkratok, Wadee</creatorcontrib><creatorcontrib>Songsupap, Tongthong</creatorcontrib><creatorcontrib>Yimlamai, Tossaporn</creatorcontrib><title>Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>Objective To evaluate the effects of repeated sprint (RS) training in hypoxia on aerobic performance, repeated sprint ability (RSA), and muscle oxygenation in Rugby Sevens. Methods Fourteen Rugby Sevens players were randomly allocated into hypoxic (RSH, F I O 2  = 14.5%, n  = 7) or normoxic (RSN, F I O 2  = 20.9%, n  = 7) groups. Both groups underwent RS training consisting of 3 sets of 6-s × 10 sprints at 140% of velocity at peak oxygen uptake ( v V O 2 peak ) on a motorized treadmill, 3 days/week for 6 weeks in addition to usual training. Hematological variables, hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) concentrations were measured. Aerobic performance, RSA, and muscle oxygenation during the running-based anaerobic sprint (RAS) test were analyzed. Results RSH caused no changes in hemoglobin concentration and hematocrit but significant improvements in V O 2 peak (7.5%, p  = 0.03, ES = 1.07), time to exhaustion (17.6%, p  = 0.05, ES = 0.92), and fatigue index (FI, − 12.3%, p  = 0.01, ES = 1.39) during the RSA test compared to baseline but not RSN. While ∆deoxygenated hemoglobin was significantly increased both after RSH and RSN ( p  &lt; 0.05), ∆tissue saturation index (− 56.1%, p  = 0.01, ES = 1.35) and ∆oxygenated hemoglobin (− 54.7%, p  = 0.04, ES = 0.97) were significantly decreased after RSH. These changes were concomitant with increased levels of HIF-1α and VEGF in serum after RSH with a strong negative correlation between ∆FI and ∆deoxygenated hemoglobin after RSH ( r  = − 0.81, p  = 0.03). 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Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pramkratok, Wadee</au><au>Songsupap, Tongthong</au><au>Yimlamai, Tossaporn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>122</volume><issue>3</issue><spage>611</spage><epage>622</epage><pages>611-622</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Objective To evaluate the effects of repeated sprint (RS) training in hypoxia on aerobic performance, repeated sprint ability (RSA), and muscle oxygenation in Rugby Sevens. Methods Fourteen Rugby Sevens players were randomly allocated into hypoxic (RSH, F I O 2  = 14.5%, n  = 7) or normoxic (RSN, F I O 2  = 20.9%, n  = 7) groups. Both groups underwent RS training consisting of 3 sets of 6-s × 10 sprints at 140% of velocity at peak oxygen uptake ( v V O 2 peak ) on a motorized treadmill, 3 days/week for 6 weeks in addition to usual training. Hematological variables, hypoxia-inducible factor-1 alpha (HIF-1α), and vascular endothelial growth factor (VEGF) concentrations were measured. Aerobic performance, RSA, and muscle oxygenation during the running-based anaerobic sprint (RAS) test were analyzed. Results RSH caused no changes in hemoglobin concentration and hematocrit but significant improvements in V O 2 peak (7.5%, p  = 0.03, ES = 1.07), time to exhaustion (17.6%, p  = 0.05, ES = 0.92), and fatigue index (FI, − 12.3%, p  = 0.01, ES = 1.39) during the RSA test compared to baseline but not RSN. While ∆deoxygenated hemoglobin was significantly increased both after RSH and RSN ( p  &lt; 0.05), ∆tissue saturation index (− 56.1%, p  = 0.01, ES = 1.35) and ∆oxygenated hemoglobin (− 54.7%, p  = 0.04, ES = 0.97) were significantly decreased after RSH. These changes were concomitant with increased levels of HIF-1α and VEGF in serum after RSH with a strong negative correlation between ∆FI and ∆deoxygenated hemoglobin after RSH ( r  = − 0.81, p  = 0.03). Conclusion There was minimal benefit from adding RSH to standard Rugby Sevens training, in eliciting improvements in aerobic performance and resistance to fatigue, possibly by enhanced muscle deoxygenation and increased serum HIF-1α and VEGF concentrations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34977961</pmid><doi>10.1007/s00421-021-04861-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0861-7075</orcidid></addata></record>
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subjects Angiogenesis
Athletic Performance - physiology
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Fatigue
Hematocrit
Hemoglobin
Human Physiology
Humans
Hypoxia
Hypoxia-inducible factor 1
Hypoxia-Inducible Factor 1, alpha Subunit - blood
Hypoxia-inducible factor 1a
Male
Muscle, Skeletal - metabolism
Occupational Medicine/Industrial Medicine
Original Article
Oxygen Consumption - physiology
Oxygenation
Physical Conditioning, Human
Rugby
Rugby - physiology
Running - physiology
Sports Medicine
Thailand
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - blood
Young Adult
title Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens
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