Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy
Problem The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies. Method of the study sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2022-03, Vol.87 (3), p.e13519-n/a |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 87 |
| creator | Mach, Pawel Köninger, Angela Reisch, Beatrix Kimmig, Rainer Gellhaus, Alexandra |
| description | Problem
The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.
Method of the study
sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7‐H4 and sPD‐L1 measurements in each trimester of pregnancy.
Results
During the course of pregnancy, the sB7‐H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD‐L1 levels increased significantly over the course of pregnancy.
Conclusion
The highest serum levels of sPD‐L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7‐H4 concentration levels in second trimester suggests different profile of T‐cell regulation in physiological pregnancy. |
| doi_str_mv | 10.1111/aji.13519 |
| format | Article |
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The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.
Method of the study
sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7‐H4 and sPD‐L1 measurements in each trimester of pregnancy.
Results
During the course of pregnancy, the sB7‐H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD‐L1 levels increased significantly over the course of pregnancy.
Conclusion
The highest serum levels of sPD‐L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7‐H4 concentration levels in second trimester suggests different profile of T‐cell regulation in physiological pregnancy.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.13519</identifier><identifier>PMID: 34974633</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Apoptosis ; B7‐H4 ; Enzyme-linked immunosorbent assay ; PD-L1 protein ; PD‐L1 ; Physiology ; Pregnancy ; Serum levels</subject><ispartof>American journal of reproductive immunology (1989), 2022-03, Vol.87 (3), p.e13519-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2022 The Authors. American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3889-8589a31728314d890931df3e149bfeb075d5065b4be2085c302c05e75fe020c63</citedby><cites>FETCH-LOGICAL-c3889-8589a31728314d890931df3e149bfeb075d5065b4be2085c302c05e75fe020c63</cites><orcidid>0000-0002-7301-6746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.13519$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.13519$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34974633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mach, Pawel</creatorcontrib><creatorcontrib>Köninger, Angela</creatorcontrib><creatorcontrib>Reisch, Beatrix</creatorcontrib><creatorcontrib>Kimmig, Rainer</creatorcontrib><creatorcontrib>Gellhaus, Alexandra</creatorcontrib><title>Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Problem
The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.
Method of the study
sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7‐H4 and sPD‐L1 measurements in each trimester of pregnancy.
Results
During the course of pregnancy, the sB7‐H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD‐L1 levels increased significantly over the course of pregnancy.
Conclusion
The highest serum levels of sPD‐L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7‐H4 concentration levels in second trimester suggests different profile of T‐cell regulation in physiological pregnancy.</description><subject>Apoptosis</subject><subject>B7‐H4</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>PD-L1 protein</subject><subject>PD‐L1</subject><subject>Physiology</subject><subject>Pregnancy</subject><subject>Serum levels</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp10EtOwzAQBmALgXgvuACyxAYWacexE9vL8iyoEkjQdZQ4k5LKTYpNQN1xBM7ISTC0sEDCG4-sT788PyEHDHosnH4-rXuMJ0yvkW2WAkSgtFwPM4g0kgLUFtnxfgoQ3rncJFtcaClSzrfJ-L61XWGR3p1_vL2PGM2bkp7KMA8F9ei6GbX4gtbTsnN1M6HPj0hN2zmPtK3o_HHh69a2k9rkls4dTpq8MYs9slHl1uP-6t4l48uLh7NhNLq9uj4bjCLDldKRSpTOOZOx4kyUSoPmrKw4MqGLCguQSZlAmhSiwBhUYjjEBhKUSYUQg0n5Ljle5s5d-9Shf85mtTdobd5g2_ksTlkaS82ECvToD52GLZrwu6CCAx1LEdTJUhnXeu-wyuaunuVukTHIvrrOQtfZd9fBHq4Su2KG5a_8KTeA_hK81hYX_ydlg5vrZeQnjR6HDg</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Mach, Pawel</creator><creator>Köninger, Angela</creator><creator>Reisch, Beatrix</creator><creator>Kimmig, Rainer</creator><creator>Gellhaus, Alexandra</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7301-6746</orcidid></search><sort><creationdate>202203</creationdate><title>Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy</title><author>Mach, Pawel ; Köninger, Angela ; Reisch, Beatrix ; Kimmig, Rainer ; Gellhaus, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-8589a31728314d890931df3e149bfeb075d5065b4be2085c302c05e75fe020c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Apoptosis</topic><topic>B7‐H4</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>PD-L1 protein</topic><topic>PD‐L1</topic><topic>Physiology</topic><topic>Pregnancy</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mach, Pawel</creatorcontrib><creatorcontrib>Köninger, Angela</creatorcontrib><creatorcontrib>Reisch, Beatrix</creatorcontrib><creatorcontrib>Kimmig, Rainer</creatorcontrib><creatorcontrib>Gellhaus, Alexandra</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mach, Pawel</au><au>Köninger, Angela</au><au>Reisch, Beatrix</au><au>Kimmig, Rainer</au><au>Gellhaus, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>87</volume><issue>3</issue><spage>e13519</spage><epage>n/a</epage><pages>e13519-n/a</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Problem
The aim of this study was to evaluate the soluble programmed death‐ligand (sPD‐L1) and soluble B7‐H4 (sB7‐H4) serum concentration levels longitudinal throughout the three trimesters of uncomplicated pregnancies.
Method of the study
sPD‐L1 and sB7‐H4 levels were determined with enzyme‐linked immunosorbent assay (ELISA). The patients (n = 26) were divided into three groups according to the pregnancy trimester. Among 26 women involved in the study 14 had longitudinal sB7‐H4 and sPD‐L1 measurements in each trimester of pregnancy.
Results
During the course of pregnancy, the sB7‐H4 blood serum levels were significant higher in second trimester than in first and third trimester, whereas sPD‐L1 levels increased significantly over the course of pregnancy.
Conclusion
The highest serum levels of sPD‐L1 in the third trimester suggest increasing suppression of maternal immunity throughout pregnancy, whereas elevated sB7‐H4 concentration levels in second trimester suggests different profile of T‐cell regulation in physiological pregnancy.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>34974633</pmid><doi>10.1111/aji.13519</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-7301-6746</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1046-7408 |
| ispartof | American journal of reproductive immunology (1989), 2022-03, Vol.87 (3), p.e13519-n/a |
| issn | 1046-7408 1600-0897 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2616279148 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Apoptosis B7‐H4 Enzyme-linked immunosorbent assay PD-L1 protein PD‐L1 Physiology Pregnancy Serum levels |
| title | Soluble PD‐L1 and B7‐H4 serum levels during the course of physiological pregnancy |
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