Somatic homozygous loss of SH2B3, and a non-Robertsonian translocation t(15;21)(q25.3;q22.1) with NTRK3 rearrangement, in an adolescent with progenitor B-cell acute lymphoblastic leukemia with the iAMP21

•Pediatric iAMP21-ALL with somatic non-Rob(15;21), NTRK3 rearrangement, and SH2B3 loss.•Sporadic iAMP21 leukemogenesis through chromothripsis and breakage-fusion-bridge.•Leukemic putative gene NTRK3 abnormality associated with iAMP21-ALL leukemogenesis.•SH2B3 function loss is associated with the dev...

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Veröffentlicht in:	Cancer genetics 2022-04, Vol.262-263, p.16-22
Hauptverfasser:	Capela de Matos, RR, Othman, MAK, Ferreira, GM, Monteso, KCA, de Souza, MT, Rouxinol, M, Melo, JB, Carreira, IM, Abdelhay, E, Liehr, T, Ribeiro, RC, Silva, MLM
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Burkitt Lymphoma - genetics Chromosomes, Human, Pair 21 - genetics Chromothripsis Core Binding Factor Alpha 2 Subunit - genetics Homozygote Humans iAMP21 NTRK3 gene Pediatric acute lymphoblastic leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cells, B-Lymphoid Ring Chromosomes RUNX1 amplification Sequence Deletion SH2B3 gene Translocation, Genetic
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