Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks

The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The master regulator of the DR networks is the cellular FLICE inhibitory protein (c-FLIP). In addition to its key role in apopt...

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Veröffentlicht in:	Trends in Cancer 2022-03, Vol.8 (3), p.190-209
Hauptverfasser:	Ivanisenko, Nikita V, Seyrek, Kamil, Hillert-Richter, Laura K, König, Corinna, Espe, Johannes, Bose, Kakoli, Lavrik, Inna N
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology CASP8 and FADD-Like Apoptosis Regulating Protein - genetics CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism fas Receptor - genetics fas Receptor - metabolism Humans Neoplasms - drug therapy Neoplasms - genetics Signal Transduction
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container_end_page	209
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container_title	Trends in Cancer
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creator	Ivanisenko, Nikita V Seyrek, Kamil Hillert-Richter, Laura K König, Corinna Espe, Johannes Bose, Kakoli Lavrik, Inna N
description	The extrinsic pathway is mediated by death receptors (DRs), including CD95 (APO-1/Fas) or TRAILR-1/2. Defects in apoptosis regulation lead to cancer and other malignancies. The master regulator of the DR networks is the cellular FLICE inhibitory protein (c-FLIP). In addition to its key role in apoptosis, c-FLIP may exert other cellular functions, including control of necroptosis, pyroptosis, nuclear factor κB (NF-κB) activation, and tumorigenesis. To gain further insight into the molecular mechanisms of c-FLIP action in cancer networks, we focus on the structure, isoforms, interactions, and post-translational modifications of c-FLIP. We also discuss various avenues to target c-FLIP in cancer cells for therapeutic benefit.
doi_str_mv	10.1016/j.trecan.2021.12.002
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subjects	Apoptosis - physiology CASP8 and FADD-Like Apoptosis Regulating Protein - genetics CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism fas Receptor - genetics fas Receptor - metabolism Humans Neoplasms - drug therapy Neoplasms - genetics Signal Transduction
title	Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks
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