O-alkyl and o-benzyl hesperetin derivative-1L attenuates inflammation and protects against alcoholic liver injury via inhibition of BRD2-NF-κB signaling pathway

A schematic model of O-alkyl and o-benzyl hesperitin derivative-1L ameliorates alcoholic liver injury by inhibiting BRD2-NF-κB signaling pathway. Therefore, HD-1L is a potential treatment option for inhibiting liver inflammation and the progression of Alcoholic liver diseases. [Display omitted] •HD-...

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Veröffentlicht in:	Toxicology (Amsterdam) 2022-01, Vol.466, p.153087-153087, Article 153087
Hauptverfasser:	Li, Juan-Juan, Lu, Xin-Yi, Jia, Pengcheng, Zhu, Lin, Wang, Ao, Bu, Fang-Tian, Zhang, Yi-Long, Huang, Cheng, Li, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Alcoholic liver injury Animals Anti-Inflammatory Agents - pharmacology Aspartate Aminotransferases - blood Bromodomain-containing protein 2 Chemical and Drug Induced Liver Injury - drug therapy Cholesterol - blood Cytokines - metabolism Hesperidin - chemistry Hesperidin - pharmacology Inflammation Inflammation - drug therapy Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL NF-κB O-alkyl and o-benzyl hesperetin derivative-1L RAW 264.7 Cells Signal Transduction - drug effects Transcription Factor RelA - metabolism Transcription Factors - metabolism Triglycerides - blood
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