Flau-A, a naphthoquinone derivative, is a promising therapeutic candidate against visceral leishmaniasis: A preliminary study

Visceral leishmaniasis (VL) is a neglected tropical disease found in tropical and subtropical regions in the world. The therapeutics used for the treatment against disease presents problems, mainly related to drug toxicity, route of administration, high cost and/or by emergence of resistant strains....

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Veröffentlicht in:	Experimental parasitology 2022-02, Vol.233, p.108205-108205, Article 108205
Hauptverfasser:	Mendonça, Débora V.C., Tavares, Grasiele S.V., Pereira, Isabela A.G., Oliveira-da-Silva, João A., Ramos, Fernanda F., Lage, Daniela P., Machado, Amanda S., Carvalho, Lívia M., Reis, Thiago A.R., Carvalho, Ana Maria R.S., Ottoni, Flaviano M., Ludolf, Fernanda, Freitas, Camila S., Martins, Vívian T., Chávez-Fumagalli, Miguel A., Duarte, Mariana C., Humbert, Maria V., Roatt, Bruno M., Menezes-Souza, Daniel, Alves, Ricardo J., Coelho, Eduardo A.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Female Flau-A Immune response Leishmania infantum - drug effects Leishmania infantum - genetics Leishmania infantum - physiology Leishmaniasis, Visceral - drug therapy Mice Mice, Inbred BALB C Micelles Naphthoquinone derivative Naphthoquinones - chemistry Naphthoquinones - pharmacology Naphthoquinones - therapeutic use Parasite Load Polymeric micelles Real-Time Polymerase Chain Reaction Spleen - parasitology Treatment Visceral leishmaniasis
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