Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI
To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T , T , and proton density) and sodium density weighted images over the whole brain. We implemented a 3D stack-of-stars MR pulse sequence which consists of interleaved proton ( H) and sodium ( Na) excitations, tailor...
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| Veröffentlicht in: | Magnetic resonance in medicine 2022-05, Vol.87 (5), p.2299-2312 |
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| container_title | Magnetic resonance in medicine |
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| creator | Yu, Zidan Hodono, Shota Dergachyova, Olga Hilbert, Tom Wang, Bili Zhang, Bei Brown, Ryan Sodickson, Daniel K Madelin, Guillaume Cloos, Martijn A |
| description | To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T
, T
, and proton density) and sodium density weighted images over the whole brain.
We implemented a 3D stack-of-stars MR pulse sequence which consists of interleaved proton (
H) and sodium (
Na) excitations, tailored slice encoding gradients that can encode the same slice for both nuclei, and simultaneous readout with different radial trajectories (
H, full-radial;
Na, center-out radial). The receive chain of our 7T scanner was modified to enable simultaneous acquisition of
H and
Na signal. A heuristically optimized flip angle train was implemented for proton MR fingerprinting (MRF). The SNR and the accuracy of proton T
and T
were evaluated in phantoms. Finally, in vivo application of the method was demonstrated in five healthy subjects.
The SNR for the simultaneous measurement was almost identical to that for the single-nucleus measurements ( |
| doi_str_mv | 10.1002/mrm.29135 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2615919667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2615919667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1304-f68f1d479bef2cf5288c0062beba7f1c3f584938d37f890be6c473940eef5e0c3</originalsourceid><addsrcrecordid>eNo9kMtOwzAURC0EoqGw4AeQl7BIudePOF6iQmmlAhKPteU4thSUNG2cLPh7Ai2sRiMdjUaHkEuEGQKw26ZrZkwjl0ckQclYyqQWxyQBJSDlqMWEnMX4CQBaK3FKJlxohUKKhIi3qhnq3m58O0TK76l1u6GKVV-1G9oGinRJn14X1G5Kyjh9tmNbnZOTYOvoLw45JR-Lh_f5Ml2_PK7md-vUIQeRhiwPWAqlCx-YC5LluQPIWOELqwI6HmQuNM9LrkKuofCZE4prAd4H6cHxKbne7267djf42Jumis7X9f6uYRlKjTrL1Ije7FHXtTF2PphtVzW2-zII5keSGSWZX0kje3WYHYrGl__knxX-DXWUXoM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615919667</pqid></control><display><type>article</type><title>Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI</title><source>MEDLINE</source><source>Wiley-Blackwell Full Collection</source><creator>Yu, Zidan ; Hodono, Shota ; Dergachyova, Olga ; Hilbert, Tom ; Wang, Bili ; Zhang, Bei ; Brown, Ryan ; Sodickson, Daniel K ; Madelin, Guillaume ; Cloos, Martijn A</creator><creatorcontrib>Yu, Zidan ; Hodono, Shota ; Dergachyova, Olga ; Hilbert, Tom ; Wang, Bili ; Zhang, Bei ; Brown, Ryan ; Sodickson, Daniel K ; Madelin, Guillaume ; Cloos, Martijn A</creatorcontrib><description>To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T
, T
, and proton density) and sodium density weighted images over the whole brain.
We implemented a 3D stack-of-stars MR pulse sequence which consists of interleaved proton (
H) and sodium (
Na) excitations, tailored slice encoding gradients that can encode the same slice for both nuclei, and simultaneous readout with different radial trajectories (
H, full-radial;
Na, center-out radial). The receive chain of our 7T scanner was modified to enable simultaneous acquisition of
H and
Na signal. A heuristically optimized flip angle train was implemented for proton MR fingerprinting (MRF). The SNR and the accuracy of proton T
and T
were evaluated in phantoms. Finally, in vivo application of the method was demonstrated in five healthy subjects.
The SNR for the simultaneous measurement was almost identical to that for the single-nucleus measurements (<2% change). The proton T
and T
maps remained similar to the results from a reference 2D MRF technique (normalized RMS error in T
≈ 4.2% and T
≈ 11.3%). Measurements in healthy subjects corroborated these results and demonstrated the feasibility of our method for in vivo application. The in vivo T
values measured using our method were lower than the results measured by other conventional techniques.
With the 3D simultaneous implementation, we were able to acquire sodium and proton density weighted images in addition to proton T
, T
, and
from
H MRF that covers the whole brain volume within 21 min.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.29135</identifier><identifier>PMID: 34971454</identifier><language>eng</language><publisher>United States</publisher><subject>Brain - diagnostic imaging ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Protons ; Sodium</subject><ispartof>Magnetic resonance in medicine, 2022-05, Vol.87 (5), p.2299-2312</ispartof><rights>2021 International Society for Magnetic Resonance in Medicine.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1304-f68f1d479bef2cf5288c0062beba7f1c3f584938d37f890be6c473940eef5e0c3</citedby><cites>FETCH-LOGICAL-c1304-f68f1d479bef2cf5288c0062beba7f1c3f584938d37f890be6c473940eef5e0c3</cites><orcidid>0000-0002-8107-5682 ; 0000-0001-7023-9162 ; 0000-0001-8207-4908 ; 0000-0002-2436-4664 ; 0000-0002-9718-1594 ; 0000-0002-2683-712X ; 0000-0002-0636-234X ; 0000-0002-5556-5792 ; 0000-0003-3405-7227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34971454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Zidan</creatorcontrib><creatorcontrib>Hodono, Shota</creatorcontrib><creatorcontrib>Dergachyova, Olga</creatorcontrib><creatorcontrib>Hilbert, Tom</creatorcontrib><creatorcontrib>Wang, Bili</creatorcontrib><creatorcontrib>Zhang, Bei</creatorcontrib><creatorcontrib>Brown, Ryan</creatorcontrib><creatorcontrib>Sodickson, Daniel K</creatorcontrib><creatorcontrib>Madelin, Guillaume</creatorcontrib><creatorcontrib>Cloos, Martijn A</creatorcontrib><title>Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T
, T
, and proton density) and sodium density weighted images over the whole brain.
We implemented a 3D stack-of-stars MR pulse sequence which consists of interleaved proton (
H) and sodium (
Na) excitations, tailored slice encoding gradients that can encode the same slice for both nuclei, and simultaneous readout with different radial trajectories (
H, full-radial;
Na, center-out radial). The receive chain of our 7T scanner was modified to enable simultaneous acquisition of
H and
Na signal. A heuristically optimized flip angle train was implemented for proton MR fingerprinting (MRF). The SNR and the accuracy of proton T
and T
were evaluated in phantoms. Finally, in vivo application of the method was demonstrated in five healthy subjects.
The SNR for the simultaneous measurement was almost identical to that for the single-nucleus measurements (<2% change). The proton T
and T
maps remained similar to the results from a reference 2D MRF technique (normalized RMS error in T
≈ 4.2% and T
≈ 11.3%). Measurements in healthy subjects corroborated these results and demonstrated the feasibility of our method for in vivo application. The in vivo T
values measured using our method were lower than the results measured by other conventional techniques.
With the 3D simultaneous implementation, we were able to acquire sodium and proton density weighted images in addition to proton T
, T
, and
from
H MRF that covers the whole brain volume within 21 min.</description><subject>Brain - diagnostic imaging</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging</subject><subject>Phantoms, Imaging</subject><subject>Protons</subject><subject>Sodium</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAURC0EoqGw4AeQl7BIudePOF6iQmmlAhKPteU4thSUNG2cLPh7Ai2sRiMdjUaHkEuEGQKw26ZrZkwjl0ckQclYyqQWxyQBJSDlqMWEnMX4CQBaK3FKJlxohUKKhIi3qhnq3m58O0TK76l1u6GKVV-1G9oGinRJn14X1G5Kyjh9tmNbnZOTYOvoLw45JR-Lh_f5Ml2_PK7md-vUIQeRhiwPWAqlCx-YC5LluQPIWOELqwI6HmQuNM9LrkKuofCZE4prAd4H6cHxKbne7267djf42Jumis7X9f6uYRlKjTrL1Ije7FHXtTF2PphtVzW2-zII5keSGSWZX0kje3WYHYrGl__knxX-DXWUXoM</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Yu, Zidan</creator><creator>Hodono, Shota</creator><creator>Dergachyova, Olga</creator><creator>Hilbert, Tom</creator><creator>Wang, Bili</creator><creator>Zhang, Bei</creator><creator>Brown, Ryan</creator><creator>Sodickson, Daniel K</creator><creator>Madelin, Guillaume</creator><creator>Cloos, Martijn A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8107-5682</orcidid><orcidid>https://orcid.org/0000-0001-7023-9162</orcidid><orcidid>https://orcid.org/0000-0001-8207-4908</orcidid><orcidid>https://orcid.org/0000-0002-2436-4664</orcidid><orcidid>https://orcid.org/0000-0002-9718-1594</orcidid><orcidid>https://orcid.org/0000-0002-2683-712X</orcidid><orcidid>https://orcid.org/0000-0002-0636-234X</orcidid><orcidid>https://orcid.org/0000-0002-5556-5792</orcidid><orcidid>https://orcid.org/0000-0003-3405-7227</orcidid></search><sort><creationdate>202205</creationdate><title>Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI</title><author>Yu, Zidan ; Hodono, Shota ; Dergachyova, Olga ; Hilbert, Tom ; Wang, Bili ; Zhang, Bei ; Brown, Ryan ; Sodickson, Daniel K ; Madelin, Guillaume ; Cloos, Martijn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1304-f68f1d479bef2cf5288c0062beba7f1c3f584938d37f890be6c473940eef5e0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain - diagnostic imaging</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Imaging</topic><topic>Phantoms, Imaging</topic><topic>Protons</topic><topic>Sodium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Zidan</creatorcontrib><creatorcontrib>Hodono, Shota</creatorcontrib><creatorcontrib>Dergachyova, Olga</creatorcontrib><creatorcontrib>Hilbert, Tom</creatorcontrib><creatorcontrib>Wang, Bili</creatorcontrib><creatorcontrib>Zhang, Bei</creatorcontrib><creatorcontrib>Brown, Ryan</creatorcontrib><creatorcontrib>Sodickson, Daniel K</creatorcontrib><creatorcontrib>Madelin, Guillaume</creatorcontrib><creatorcontrib>Cloos, Martijn A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Zidan</au><au>Hodono, Shota</au><au>Dergachyova, Olga</au><au>Hilbert, Tom</au><au>Wang, Bili</au><au>Zhang, Bei</au><au>Brown, Ryan</au><au>Sodickson, Daniel K</au><au>Madelin, Guillaume</au><au>Cloos, Martijn A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2022-05</date><risdate>2022</risdate><volume>87</volume><issue>5</issue><spage>2299</spage><epage>2312</epage><pages>2299-2312</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>To develop a 3D MR technique to simultaneously acquire proton multiparametric maps (T
, T
, and proton density) and sodium density weighted images over the whole brain.
We implemented a 3D stack-of-stars MR pulse sequence which consists of interleaved proton (
H) and sodium (
Na) excitations, tailored slice encoding gradients that can encode the same slice for both nuclei, and simultaneous readout with different radial trajectories (
H, full-radial;
Na, center-out radial). The receive chain of our 7T scanner was modified to enable simultaneous acquisition of
H and
Na signal. A heuristically optimized flip angle train was implemented for proton MR fingerprinting (MRF). The SNR and the accuracy of proton T
and T
were evaluated in phantoms. Finally, in vivo application of the method was demonstrated in five healthy subjects.
The SNR for the simultaneous measurement was almost identical to that for the single-nucleus measurements (<2% change). The proton T
and T
maps remained similar to the results from a reference 2D MRF technique (normalized RMS error in T
≈ 4.2% and T
≈ 11.3%). Measurements in healthy subjects corroborated these results and demonstrated the feasibility of our method for in vivo application. The in vivo T
values measured using our method were lower than the results measured by other conventional techniques.
With the 3D simultaneous implementation, we were able to acquire sodium and proton density weighted images in addition to proton T
, T
, and
from
H MRF that covers the whole brain volume within 21 min.</abstract><cop>United States</cop><pmid>34971454</pmid><doi>10.1002/mrm.29135</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8107-5682</orcidid><orcidid>https://orcid.org/0000-0001-7023-9162</orcidid><orcidid>https://orcid.org/0000-0001-8207-4908</orcidid><orcidid>https://orcid.org/0000-0002-2436-4664</orcidid><orcidid>https://orcid.org/0000-0002-9718-1594</orcidid><orcidid>https://orcid.org/0000-0002-2683-712X</orcidid><orcidid>https://orcid.org/0000-0002-0636-234X</orcidid><orcidid>https://orcid.org/0000-0002-5556-5792</orcidid><orcidid>https://orcid.org/0000-0003-3405-7227</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 2022-05, Vol.87 (5), p.2299-2312 |
| issn | 0740-3194 1522-2594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2615919667 |
| source | MEDLINE; Wiley-Blackwell Full Collection |
| subjects | Brain - diagnostic imaging Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging Phantoms, Imaging Protons Sodium |
| title | Simultaneous 3D acquisition of 1 H MRF and 23 Na MRI |
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