N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer

N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant m6A modifications and expression of m6A regulators. However, how m6A readers interpret oncogenic m6A methylome to promote malignant transformation remains to be illustrated. YTH N6-methyl...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2022-04, Vol.162 (4), p.1183-1196
Hauptverfasser:	Wang, Shiyan, Gao, Shanshan, Zeng, Yong, Zhu, Lin, Mo, Yulin, Wong, Chi Chun, Bao, Yi, Su, Peiran, Zhai, Jianning, Wang, Lina, Soares, Fraser, Xu, Xin, Chen, Huarong, Hezaveh, Kebria, Ci, Xinpei, He, Aobo, McGaha, Tracy, O’Brien, Catherine, Rottapel, Robert, Kang, Wei, Wu, Jianfeng, Zheng, Gang, Cai, Zongwei, Yu, Jun, He, Housheng Hansen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Animals ARHGEF2 Carcinogenesis - genetics Colorectal Cancer Colorectal Neoplasms - pathology Gene Expression Regulation, Neoplastic Humans Liposomes Mice N6-Methyladenosine Nanoparticle Nanoparticles Rho Guanine Nucleotide Exchange Factors - genetics Rho Guanine Nucleotide Exchange Factors - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism RNA, Small Interfering RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism YTHDF1
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