Dopamine D3 receptor in the nucleus accumbens alleviates neuroinflammation in a mouse model of depressive-like behavior

•NAc neuroinflammation induced by intra-NAc injection of LPS leads to depressive-like disorders.•NAc neuroinflammation results in D3R expression decline and microglial activation in the NAc.•D3R in the NAc shows a crucial role in the initiation and development of depressive-like behaviors.•D3R inhib...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2022-03, Vol.101, p.165-179
Hauptverfasser:	Wang, Jing, Lai, Simin, Wang, Rui, Zhou, Ting, Dong, Nan, Zhu, Li, Chen, Teng, Zhang, Xia, Chen, Yanjiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt signaling pathway Animals D3R Depression Depressive-like behavior Disease Models, Animal Inflammation - metabolism Mice NAc neuroinflammation Neuroinflammatory Diseases Nucleus Accumbens - metabolism Proinflammatory microglia Proto-Oncogene Proteins c-akt - metabolism Receptors, Dopamine D3 - metabolism
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