Effect of physical activity and vitamin D compared with vitamin D alone on muscle strength, back flexibility and aerobic activity in patients with chronic kidney disease: A comparative study from Pakistan
Background and Objectives: To compare the differences in musculoskeletal health with vitamin D alone in comparison with vitamin D with physical activity (PA) among chronic kidney disease (CKD) patients. Methods and Study Design: An open labeled, randomized, controlled trial was conducted at two tert...
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| Veröffentlicht in: | Asia Pacific Journal of Clinical Nutrition 2021-12, Vol.30 (4), p.566-572 |
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| container_title | Asia Pacific Journal of Clinical Nutrition |
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| creator | Ahmed, Bilal Nasir, Kiran Mehmood, Asim Abid, Muhammad Abbas Zehra, Nawazish Abbas Khan, Aysha Habib Hussain, Syed Ather Kashif, Waqar Uddin Iqbal, Romaina |
| description | Background and Objectives: To compare the differences in musculoskeletal health with vitamin D alone in comparison with vitamin D with physical activity (PA) among chronic kidney disease (CKD) patients. Methods and Study Design: An open labeled, randomized, controlled trial was conducted at two tertiary care centers in Pakistan. Patients with CKD stage 2-4 and vitamin D deficiency (0.05). Sensitivity analysis within group comparison shows rise of bicep strength from 13.8 kg to 15.2 kg in the VD alone arm (p=0.05); however, in the VDPA arm, there is a greater difference of 14.3 kg to 17.2 kg (p |
| doi_str_mv | 10.6133/apjcn.202112_30(4).0002 |
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Methods and Study Design: An open labeled, randomized, controlled trial was conducted at two tertiary care centers in Pakistan. Patients with CKD stage 2-4 and vitamin D deficiency (<20 ng/mL) were recruited in the trial. Both the arms were given oral vitamin D (cholecalciferol) drops (4000 IU) once daily for three months. One arm received only vitamin D (VD arm), while the second arm received vitamin D along with PA (VDPA arm). Results: Of the 1,235 CKD stage 2-4 subjects contacted, forty-six subjects were enrolled. Eighteen were assigned to VD arm and twenty-eight were assigned to VDPA arm. Between groups comparison shows that bicep strength increases from 15 to 17 kg. Likewise, back flexibility and aerobic fitness also increased among those who receive vitamin D and physical activity, however these differences were not statistically significant (p>0.05). Sensitivity analysis within group comparison shows rise of bicep strength from 13.8 kg to 15.2 kg in the VD alone arm (p=0.05); however, in the VDPA arm, there is a greater difference of 14.3 kg to 17.2 kg (p<0.001). Conclusions: Targeted PA among CKD patients has potential to improve bicep strength and back flexibility. However, as the sample size was small, further studies would be required to suggest whether a PA should be included as part of the treatment regimen.</description><identifier>ISSN: 0964-7058</identifier><identifier>EISSN: 1440-6047</identifier><identifier>DOI: 10.6133/apjcn.202112_30(4).0002</identifier><identifier>PMID: 34967184</identifier><language>eng</language><publisher>Clayton, Vic: HEC Press</publisher><subject>Cholecalciferol ; Chronic renal failure ; Complications ; Creatinine ; Exercise ; Health aspects ; Humans ; Kidney diseases ; Metabolism ; Muscle Strength ; Musculoskeletal system ; Nephrology ; Pakistan ; Physical fitness ; Population ; Quality of life ; Renal Insufficiency, Chronic - drug therapy ; Sensitivity analysis ; Statistical analysis ; Treatment ; Vitamin D ; Vitamin D deficiency ; Vitamin D Deficiency - drug therapy ; Vitamin deficiency</subject><ispartof>Asia Pacific Journal of Clinical Nutrition, 2021-12, Vol.30 (4), p.566-572</ispartof><rights>Copyright HEC Press Dec 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34967184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Nasir, Kiran</creatorcontrib><creatorcontrib>Mehmood, Asim</creatorcontrib><creatorcontrib>Abid, Muhammad Abbas</creatorcontrib><creatorcontrib>Zehra, Nawazish Abbas</creatorcontrib><creatorcontrib>Khan, Aysha Habib</creatorcontrib><creatorcontrib>Hussain, Syed Ather</creatorcontrib><creatorcontrib>Kashif, Waqar Uddin</creatorcontrib><creatorcontrib>Iqbal, Romaina</creatorcontrib><title>Effect of physical activity and vitamin D compared with vitamin D alone on muscle strength, back flexibility and aerobic activity in patients with chronic kidney disease: A comparative study from Pakistan</title><title>Asia Pacific Journal of Clinical Nutrition</title><addtitle>Asia Pac J Clin Nutr</addtitle><description>Background and Objectives: To compare the differences in musculoskeletal health with vitamin D alone in comparison with vitamin D with physical activity (PA) among chronic kidney disease (CKD) patients. Methods and Study Design: An open labeled, randomized, controlled trial was conducted at two tertiary care centers in Pakistan. Patients with CKD stage 2-4 and vitamin D deficiency (<20 ng/mL) were recruited in the trial. Both the arms were given oral vitamin D (cholecalciferol) drops (4000 IU) once daily for three months. One arm received only vitamin D (VD arm), while the second arm received vitamin D along with PA (VDPA arm). Results: Of the 1,235 CKD stage 2-4 subjects contacted, forty-six subjects were enrolled. Eighteen were assigned to VD arm and twenty-eight were assigned to VDPA arm. Between groups comparison shows that bicep strength increases from 15 to 17 kg. Likewise, back flexibility and aerobic fitness also increased among those who receive vitamin D and physical activity, however these differences were not statistically significant (p>0.05). Sensitivity analysis within group comparison shows rise of bicep strength from 13.8 kg to 15.2 kg in the VD alone arm (p=0.05); however, in the VDPA arm, there is a greater difference of 14.3 kg to 17.2 kg (p<0.001). Conclusions: Targeted PA among CKD patients has potential to improve bicep strength and back flexibility. However, as the sample size was small, further studies would be required to suggest whether a PA should be included as part of the treatment regimen.</description><subject>Cholecalciferol</subject><subject>Chronic renal failure</subject><subject>Complications</subject><subject>Creatinine</subject><subject>Exercise</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Metabolism</subject><subject>Muscle Strength</subject><subject>Musculoskeletal system</subject><subject>Nephrology</subject><subject>Pakistan</subject><subject>Physical fitness</subject><subject>Population</subject><subject>Quality of life</subject><subject>Renal Insufficiency, Chronic - drug therapy</subject><subject>Sensitivity analysis</subject><subject>Statistical analysis</subject><subject>Treatment</subject><subject>Vitamin D</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin deficiency</subject><issn>0964-7058</issn><issn>1440-6047</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqlkk1v1DAQhiMEomXhL4AlLkVii7_iJNyqUiioEhzK2Zr4o-ttYqe2U9j_yI_CZbfawpXTjD2P3hl73qp6RfCxIIy9g2mt_DHFlBAqGT7ib44xxvRRdUg4x0uBefO4OsSd4MsG1-1B9SyldSEYx_XT6oDxTjSk5YfVrzNrjcooWDStNskpGBCo7G5d3iDwGpUERufRB6TCOEE0Gv1wefXgHobgDQoejXNSg0EpR-Ov8uot6kFdIzuYn653w70gmBh6p_ZdisgE2Rmf01ZarWLwhbh22psN0i4ZSOY9OtmNUODbuzaz3iAbw4i-wbVLGfzz6omFIZkXu7iovn88uzw9X158_fT59ORiCUywvKyN7oiy0FFhtO5tOdV1S4wWTQ_QaqAN46A01R3rW6Jwg21vqejAcmU6wRbV0VZ3iuFmNinL0SVlhgG8CXOSVJCaNw0vq1pUr_9B12GOvkxXKMq4YITVhXq5o-Z-NFpO0Y0QN_J-TwW43AJxdFmqMAxlaS74tIacZPmfqFbSeRv-1EO8kjo4SbBkjIh9gXakbbqWNqQTxTtF9ssDWZjA5v8RO9-KgYsuu_1D72x450K582sJFJek-JH8faiFkHVD2W8xG-Ze</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Ahmed, Bilal</creator><creator>Nasir, Kiran</creator><creator>Mehmood, Asim</creator><creator>Abid, Muhammad Abbas</creator><creator>Zehra, Nawazish Abbas</creator><creator>Khan, Aysha Habib</creator><creator>Hussain, Syed Ather</creator><creator>Kashif, Waqar Uddin</creator><creator>Iqbal, Romaina</creator><general>HEC Press</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20211201</creationdate><title>Effect of physical activity and vitamin D compared with vitamin D alone on muscle strength, back flexibility and aerobic activity in patients with chronic kidney disease: A comparative study from Pakistan</title><author>Ahmed, Bilal ; Nasir, Kiran ; Mehmood, Asim ; Abid, Muhammad Abbas ; Zehra, Nawazish Abbas ; Khan, Aysha Habib ; Hussain, Syed Ather ; Kashif, Waqar Uddin ; Iqbal, Romaina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a363t-5ed91cfa926eddbfd915581ed67baa8da2734acd2d93b81c070fbf269af4ce963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cholecalciferol</topic><topic>Chronic renal failure</topic><topic>Complications</topic><topic>Creatinine</topic><topic>Exercise</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Metabolism</topic><topic>Muscle Strength</topic><topic>Musculoskeletal system</topic><topic>Nephrology</topic><topic>Pakistan</topic><topic>Physical fitness</topic><topic>Population</topic><topic>Quality of life</topic><topic>Renal Insufficiency, Chronic - drug therapy</topic><topic>Sensitivity analysis</topic><topic>Statistical analysis</topic><topic>Treatment</topic><topic>Vitamin D</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - drug therapy</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Bilal</creatorcontrib><creatorcontrib>Nasir, Kiran</creatorcontrib><creatorcontrib>Mehmood, Asim</creatorcontrib><creatorcontrib>Abid, Muhammad Abbas</creatorcontrib><creatorcontrib>Zehra, Nawazish Abbas</creatorcontrib><creatorcontrib>Khan, Aysha Habib</creatorcontrib><creatorcontrib>Hussain, Syed Ather</creatorcontrib><creatorcontrib>Kashif, Waqar Uddin</creatorcontrib><creatorcontrib>Iqbal, Romaina</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Bilal</au><au>Nasir, Kiran</au><au>Mehmood, Asim</au><au>Abid, Muhammad Abbas</au><au>Zehra, Nawazish Abbas</au><au>Khan, Aysha Habib</au><au>Hussain, Syed Ather</au><au>Kashif, Waqar Uddin</au><au>Iqbal, Romaina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of physical activity and vitamin D compared with vitamin D alone on muscle strength, back flexibility and aerobic activity in patients with chronic kidney disease: A comparative study from Pakistan</atitle><jtitle>Asia Pacific Journal of Clinical Nutrition</jtitle><addtitle>Asia Pac J Clin Nutr</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>30</volume><issue>4</issue><spage>566</spage><epage>572</epage><pages>566-572</pages><issn>0964-7058</issn><eissn>1440-6047</eissn><abstract>Background and Objectives: To compare the differences in musculoskeletal health with vitamin D alone in comparison with vitamin D with physical activity (PA) among chronic kidney disease (CKD) patients. Methods and Study Design: An open labeled, randomized, controlled trial was conducted at two tertiary care centers in Pakistan. Patients with CKD stage 2-4 and vitamin D deficiency (<20 ng/mL) were recruited in the trial. Both the arms were given oral vitamin D (cholecalciferol) drops (4000 IU) once daily for three months. One arm received only vitamin D (VD arm), while the second arm received vitamin D along with PA (VDPA arm). Results: Of the 1,235 CKD stage 2-4 subjects contacted, forty-six subjects were enrolled. Eighteen were assigned to VD arm and twenty-eight were assigned to VDPA arm. Between groups comparison shows that bicep strength increases from 15 to 17 kg. Likewise, back flexibility and aerobic fitness also increased among those who receive vitamin D and physical activity, however these differences were not statistically significant (p>0.05). Sensitivity analysis within group comparison shows rise of bicep strength from 13.8 kg to 15.2 kg in the VD alone arm (p=0.05); however, in the VDPA arm, there is a greater difference of 14.3 kg to 17.2 kg (p<0.001). Conclusions: Targeted PA among CKD patients has potential to improve bicep strength and back flexibility. However, as the sample size was small, further studies would be required to suggest whether a PA should be included as part of the treatment regimen.</abstract><cop>Clayton, Vic</cop><pub>HEC Press</pub><pmid>34967184</pmid><doi>10.6133/apjcn.202112_30(4).0002</doi><tpages>7</tpages></addata></record> |
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| subjects | Cholecalciferol Chronic renal failure Complications Creatinine Exercise Health aspects Humans Kidney diseases Metabolism Muscle Strength Musculoskeletal system Nephrology Pakistan Physical fitness Population Quality of life Renal Insufficiency, Chronic - drug therapy Sensitivity analysis Statistical analysis Treatment Vitamin D Vitamin D deficiency Vitamin D Deficiency - drug therapy Vitamin deficiency |
| title | Effect of physical activity and vitamin D compared with vitamin D alone on muscle strength, back flexibility and aerobic activity in patients with chronic kidney disease: A comparative study from Pakistan |
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