Preparation of (E)‑1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes

Preparation of (E)‑1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes

A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was compatible with a broad range of substrates, espec...

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Veröffentlicht in:Journal of organic chemistry 2022-01, Vol.87 (2), p.1589-1597
Hauptverfasser: Liu, Zhi-Kai, Yang, Ying, Zhan, Zhuang-Ping
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Alkadienes
Catalysis
Palladium
Stereoisomerism
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container_title Journal of organic chemistry
container_volume 87
creator Liu, Zhi-Kai
Yang, Ying
Zhan, Zhuang-Ping
description A general and efficient palladium catalyzed hydroalkynylation of allenes was developed to produce synthetically versatile (E)-1,3-enyne derivatives with high regio- and stereoselectivity. This catalytic system proceeded under mild conditions and was compatible with a broad range of substrates, especially for allenes without electron-bias groups. This work further broadens the synthetic potential of these scaffolds in organic synthesis and medicinal chemistry.
doi_str_mv 10.1021/acs.joc.1c02732
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subjects Alkadienes
Catalysis
Palladium
Stereoisomerism
title Preparation of (E)‑1,3-Enyne Derivatives through Palladium Catalyzed Hydroalkynylation of Allenes
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