Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study
This study examined changes in force distribution between the neochordae corresponding to different ventricular anchor locations. Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex...
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| Veröffentlicht in: | The Annals of thoracic surgery 2022-04, Vol.113 (4), p.1378-1384 |
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| container_title | The Annals of thoracic surgery |
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| creator | Sadri, Vahid Kohli, Keshav Jimenez, Jorge H. Cranford, William S. Berry, Abigail R. Grinberg, Daniel Chitwood, W. Randolph Yoganathan, Ajit P. |
| description | This study examined changes in force distribution between the neochordae corresponding to different ventricular anchor locations.
Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex, papillary muscle base, or papillary muscle tip location. The neochordae were attached at three sites along the P2 leaflet segment: P2Lateral; P2Center, and P2Medial. Mitral regurgitation was induced by cutting posterior leaflet P2 marginal chordae. The forces on each neochord required to restore normal mitral valve coaptation were quantified for different ventricular anchoring origins and leaflet insertion sites.
The results showed that under both normotensive and hypertensive conditions, the force exerted was much higher at P2Center than either P2Lateral or P2Medial, independent of ventricular anchor location. Also, forces on both P2Lateral and P2Medial were not statistically different.
Artificial neochordae treatment for all anchoring locations was effective in correcting induced mitral regurgitation. The P2 central neochordae had a significantly higher force than both lateral neochords under all conditions.
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| doi_str_mv | 10.1016/j.athoracsur.2021.10.072 |
| format | Article |
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Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex, papillary muscle base, or papillary muscle tip location. The neochordae were attached at three sites along the P2 leaflet segment: P2Lateral; P2Center, and P2Medial. Mitral regurgitation was induced by cutting posterior leaflet P2 marginal chordae. The forces on each neochord required to restore normal mitral valve coaptation were quantified for different ventricular anchoring origins and leaflet insertion sites.
The results showed that under both normotensive and hypertensive conditions, the force exerted was much higher at P2Center than either P2Lateral or P2Medial, independent of ventricular anchor location. Also, forces on both P2Lateral and P2Medial were not statistically different.
Artificial neochordae treatment for all anchoring locations was effective in correcting induced mitral regurgitation. The P2 central neochordae had a significantly higher force than both lateral neochords under all conditions.
[Display omitted]</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2021.10.072</identifier><identifier>PMID: 34958769</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Chordae Tendineae - surgery ; Humans ; Mitral Valve - surgery ; Mitral Valve Insufficiency - surgery ; Mitral Valve Prolapse ; Papillary Muscles - surgery ; Swine</subject><ispartof>The Annals of thoracic surgery, 2022-04, Vol.113 (4), p.1378-1384</ispartof><rights>2022 The Society of Thoracic Surgeons</rights><rights>Copyright © 2022 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-85cc4aababc33b989214df3ba3c40741f4ced17b4ca7ec90d69b20a282ad3c443</citedby><cites>FETCH-LOGICAL-c374t-85cc4aababc33b989214df3ba3c40741f4ced17b4ca7ec90d69b20a282ad3c443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34958769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadri, Vahid</creatorcontrib><creatorcontrib>Kohli, Keshav</creatorcontrib><creatorcontrib>Jimenez, Jorge H.</creatorcontrib><creatorcontrib>Cranford, William S.</creatorcontrib><creatorcontrib>Berry, Abigail R.</creatorcontrib><creatorcontrib>Grinberg, Daniel</creatorcontrib><creatorcontrib>Chitwood, W. Randolph</creatorcontrib><creatorcontrib>Yoganathan, Ajit P.</creatorcontrib><title>Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>This study examined changes in force distribution between the neochordae corresponding to different ventricular anchor locations.
Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex, papillary muscle base, or papillary muscle tip location. The neochordae were attached at three sites along the P2 leaflet segment: P2Lateral; P2Center, and P2Medial. Mitral regurgitation was induced by cutting posterior leaflet P2 marginal chordae. The forces on each neochord required to restore normal mitral valve coaptation were quantified for different ventricular anchoring origins and leaflet insertion sites.
The results showed that under both normotensive and hypertensive conditions, the force exerted was much higher at P2Center than either P2Lateral or P2Medial, independent of ventricular anchor location. Also, forces on both P2Lateral and P2Medial were not statistically different.
Artificial neochordae treatment for all anchoring locations was effective in correcting induced mitral regurgitation. The P2 central neochordae had a significantly higher force than both lateral neochords under all conditions.
[Display omitted]</description><subject>Animals</subject><subject>Chordae Tendineae - surgery</subject><subject>Humans</subject><subject>Mitral Valve - surgery</subject><subject>Mitral Valve Insufficiency - surgery</subject><subject>Mitral Valve Prolapse</subject><subject>Papillary Muscles - surgery</subject><subject>Swine</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtOwzAQhi0EoqVwBeQlmwS_8mJXKgqRCix4bC1n4ohUSVzsBKm34SycDEctsESyZNn_NzP2hxCmJKSExpfrUPVvxipwgw0ZYdRfhyRhB2hKo4gFMYuyQzQlhPBAZEk0QSfOrf2R-fgYTbjIojSJsynK83ajoMemwvMOfE-8MqD62nTYr_u6t6rBD9qMUak0XhoL2l15GOfd1-erBwx-6odye4qOKtU4fbbfZ-hlefO8uAtWj7f5Yr4KgCeiD9IIQChVqAI4L7I0Y1SUFS8UB0ESQSsBuqRJIUAlGjJSxlnBiGIpU6VHBJ-hi13fjTXvg3a9bGsHumlUp83gJItpRBlLOPNoukPBGuesruTG1q2yW0mJHEXKtfwTKUeRY-JF-tLz_ZShaHX5W_hjzgPXO0D7v37U2koHte7842uroZelqf-f8g2Rb4oi</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Sadri, Vahid</creator><creator>Kohli, Keshav</creator><creator>Jimenez, Jorge H.</creator><creator>Cranford, William S.</creator><creator>Berry, Abigail R.</creator><creator>Grinberg, Daniel</creator><creator>Chitwood, W. Randolph</creator><creator>Yoganathan, Ajit P.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202204</creationdate><title>Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study</title><author>Sadri, Vahid ; Kohli, Keshav ; Jimenez, Jorge H. ; Cranford, William S. ; Berry, Abigail R. ; Grinberg, Daniel ; Chitwood, W. Randolph ; Yoganathan, Ajit P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-85cc4aababc33b989214df3ba3c40741f4ced17b4ca7ec90d69b20a282ad3c443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Chordae Tendineae - surgery</topic><topic>Humans</topic><topic>Mitral Valve - surgery</topic><topic>Mitral Valve Insufficiency - surgery</topic><topic>Mitral Valve Prolapse</topic><topic>Papillary Muscles - surgery</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadri, Vahid</creatorcontrib><creatorcontrib>Kohli, Keshav</creatorcontrib><creatorcontrib>Jimenez, Jorge H.</creatorcontrib><creatorcontrib>Cranford, William S.</creatorcontrib><creatorcontrib>Berry, Abigail R.</creatorcontrib><creatorcontrib>Grinberg, Daniel</creatorcontrib><creatorcontrib>Chitwood, W. Randolph</creatorcontrib><creatorcontrib>Yoganathan, Ajit P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadri, Vahid</au><au>Kohli, Keshav</au><au>Jimenez, Jorge H.</au><au>Cranford, William S.</au><au>Berry, Abigail R.</au><au>Grinberg, Daniel</au><au>Chitwood, W. Randolph</au><au>Yoganathan, Ajit P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2022-04</date><risdate>2022</risdate><volume>113</volume><issue>4</issue><spage>1378</spage><epage>1384</epage><pages>1378-1384</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>This study examined changes in force distribution between the neochordae corresponding to different ventricular anchor locations.
Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex, papillary muscle base, or papillary muscle tip location. The neochordae were attached at three sites along the P2 leaflet segment: P2Lateral; P2Center, and P2Medial. Mitral regurgitation was induced by cutting posterior leaflet P2 marginal chordae. The forces on each neochord required to restore normal mitral valve coaptation were quantified for different ventricular anchoring origins and leaflet insertion sites.
The results showed that under both normotensive and hypertensive conditions, the force exerted was much higher at P2Center than either P2Lateral or P2Medial, independent of ventricular anchor location. Also, forces on both P2Lateral and P2Medial were not statistically different.
Artificial neochordae treatment for all anchoring locations was effective in correcting induced mitral regurgitation. The P2 central neochordae had a significantly higher force than both lateral neochords under all conditions.
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| ispartof | The Annals of thoracic surgery, 2022-04, Vol.113 (4), p.1378-1384 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Chordae Tendineae - surgery Humans Mitral Valve - surgery Mitral Valve Insufficiency - surgery Mitral Valve Prolapse Papillary Muscles - surgery Swine |
| title | Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study |
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