Intracellular hydrogen peroxide produced by 6-hydroxydopamine is a trigger for nigral dopaminergic degeneration of rats via rapid influx of extracellular Zn2

•6-OHDA taken up through dopamine transporters produces H2O2 in dopaminergic neurons.•H2O2 is retrogradely transported to presynaptic glutamatergic terminals.•H2O2 activates TRPM2 channels and glutamate accumulates in the extracellular compartment.•H2O2 induces intracellular Zn2+ dysregulation via A...

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Veröffentlicht in:	Neurotoxicology (Park Forest South) 2022-03, Vol.89, p.1-8
Hauptverfasser:	Nishio, Ryusuke, Morioka, Hiroki, Takeuchi, Azusa, Saeki, Nana, Furuhata, Ryo, Katahira, Misa, Chinenn, Takato, Tamura, Haruna, Tamano, Haruna, Takeda, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine 6-OHDA Anthranilic acid Channels Coinjection Degeneration Dopamine Dopamine receptors Dopamine transporter Dopaminergic neuron Glutamatergic transmission Hydrogen peroxide Injection Intracellular Movement disorders Neurodegeneration Parkinson's disease Receptor mechanisms Receptors Substantia nigra Toxicity Transient receptor potential proteins Transport buildings, stations and terminals TRPM2 cation channel Zinc Zn2 α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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