Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease

•TREM2 expression elevates at 3-months-old APP/PS1 mice and continue to increase with aging.•Downregulation of TREM2 aggravates cognitive deficits in APP/PS1 mice.•Downregulation of TREM2 increases Aβ accumulation and neuroinflammation in APP/PS1 mice.•Downregulation of TREM2 promotes neuronal and s...

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Veröffentlicht in:	Molecular immunology 2022-02, Vol.142, p.22-36
Hauptverfasser:	Ruganzu, John Bosco, Peng, Xiaoqian, He, Yingying, Wu, Xiangyuan, Zheng, Quzhao, Ding, Bo, Lin, Chengheng, Guo, Hongsong, Yang, Zikang, Zhang, Xiao, Yang, Weina
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid beta-Protein Precursor - metabolism Animals Brain - cytology Brain - metabolism Cell Line Cytokines - metabolism Disease Models, Animal Down-Regulation - genetics Female Gliosis - pathology Male MAP Kinase Signaling System - genetics Maze Learning - physiology Membrane Glycoproteins - biosynthesis Memory, Short-Term - physiology Mice Mice, Transgenic Microglia Microglia - metabolism Mitogen-Activated Protein Kinases - metabolism Neuroglia - cytology Neuroglia - pathology Neuroinflammation Neuroinflammatory Diseases - genetics Neuroinflammatory Diseases - immunology Neuroinflammatory Diseases - pathology Plaque, Amyloid - pathology Receptors, Immunologic - biosynthesis Toll-Like Receptor 4 - metabolism Triggering receptor expressed on myeloid cells 2 β-amyloid
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