Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet
Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for...
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| Veröffentlicht in: | Pharmaceuticals (Basel, Switzerland) Switzerland), 2021-12, Vol.14 (12), p.1327, Article 1327 |
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| creator | Rosch, Moritz Lucas, Kurt Al-Gousous, Jozef Poeschl, Ulrich Langguth, Peter |
| description | Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations. |
| doi_str_mv | 10.3390/ph14121327 |
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Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.</description><identifier>ISSN: 1424-8247</identifier><identifier>EISSN: 1424-8247</identifier><identifier>DOI: 10.3390/ph14121327</identifier><identifier>PMID: 34959728</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Chemical reactions ; Chemistry, Medicinal ; dynamic vapor sorption ; effervescent ; Hydrogen ; Lactose ; Life Sciences & Biomedicine ; Magnesium ; Metals ; Pharmacology & Pharmacy ; Physiology ; Product development ; roller compaction ; Science & Technology ; stability ; tablet</subject><ispartof>Pharmaceuticals (Basel, Switzerland), 2021-12, Vol.14 (12), p.1327, Article 1327</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.</description><subject>Chemical reactions</subject><subject>Chemistry, Medicinal</subject><subject>dynamic vapor sorption</subject><subject>effervescent</subject><subject>Hydrogen</subject><subject>Lactose</subject><subject>Life Sciences & Biomedicine</subject><subject>Magnesium</subject><subject>Metals</subject><subject>Pharmacology & Pharmacy</subject><subject>Physiology</subject><subject>Product development</subject><subject>roller compaction</subject><subject>Science & Technology</subject><subject>stability</subject><subject>tablet</subject><issn>1424-8247</issn><issn>1424-8247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNqNkk1v1DAQhiMEoqVw4QegSFwQKODxR2xfkFDUL6mCSzlbtjPZzSprL05SVH493qYsLSfkg63xo0fjd1wUr4F8ZEyTT7s1cKDAqHxSHAOnvFKUy6cPzkfFi3HcECJkJp8XR4xroSVVx8XXs5i282CnPobShrZs1jZZP2Hqfy3F2OV6edp1mG5w9Bim8uK2TXGFoTrHgCljYVVeWzfg9LJ41tlhxFf3-0nx_ez0urmorr6dXzZfrirPJZ2qViCpJVrJUNdEaNUKLQghVEuuFG0VUorQaeoVEA9Mc9fxGrraCc-FBnZSXC7eNtqN2aV-a9OtibY3d4WYVsamqfcDGnBOYacYaEAOrs1GIqljUOfEnJfZ9Xlx7Wa3xXb_wmSHR9LHN6Ffm1W8MUqSvFgWvLsXpPhjxnEy2z4HNQw2YJxHQ2sQAFRoktG3_6CbOKeQo9pTVAFjat_R-4XyKY5jwu7QDBCzH7n5O_IMv3nY_gH9M-MMfFiAn-hiN_oeg8cDllOXrNaa6nwi-2TV_9NNP919kibOYWK_AXdAxZw</recordid><startdate>20211218</startdate><enddate>20211218</enddate><creator>Rosch, Moritz</creator><creator>Lucas, Kurt</creator><creator>Al-Gousous, Jozef</creator><creator>Poeschl, Ulrich</creator><creator>Langguth, Peter</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8267-7397</orcidid></search><sort><creationdate>20211218</creationdate><title>Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet</title><author>Rosch, Moritz ; 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| subjects | Chemical reactions Chemistry, Medicinal dynamic vapor sorption effervescent Hydrogen Lactose Life Sciences & Biomedicine Magnesium Metals Pharmacology & Pharmacy Physiology Product development roller compaction Science & Technology stability tablet |
| title | Formulation and Characterization of an Effervescent Hydrogen-Generating Tablet |
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