The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation

Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque‐induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied preb...

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Veröffentlicht in:	IUBMB life 2022-08, Vol.74 (8), p.748-753
Hauptverfasser:	Deng, Shin‐Meng, Chen, Chia‐Jung, Lin, Hung‐Lung, Cheng, Irene H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid Cognitive ability Inflammation Neurodegeneration Neurodegenerative diseases neuroinflammation synbiotics
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description	Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. Amyloid plaque‐induced neuroinflammation exacerbates neurodegeneration and cognitive impairment in AD. To reduce neuroinflammation, we applied prebiotics or synbiotics to modulate the gut–brain axis in the AD mouse model. AD‐like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut–brain axis is a potential approach to delay AD progression.
doi_str_mv	10.1002/iub.2589
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AD‐like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut–brain axis is a potential approach to delay AD progression.</description><identifier>ISSN: 1521-6543</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1002/iub.2589</identifier><identifier>PMID: 34962691</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Alzheimer's disease ; Amyloid ; Cognitive ability ; Inflammation ; Neurodegeneration ; Neurodegenerative diseases ; neuroinflammation ; synbiotics</subject><ispartof>IUBMB life, 2022-08, Vol.74 (8), p.748-753</ispartof><rights>2021 International Union of Biochemistry and Molecular Biology</rights><rights>2021 International Union of Biochemistry and Molecular Biology.</rights><rights>2022 International Union of Biochemistry and Molecular Biology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3499-80f18709331c51d34f7bff3a9b0de5e17d2e0e099effae5033268a98873510023</citedby><cites>FETCH-LOGICAL-c3499-80f18709331c51d34f7bff3a9b0de5e17d2e0e099effae5033268a98873510023</cites><orcidid>0000-0002-3737-3877 ; 0000-0002-6739-5452</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fiub.2589$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fiub.2589$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34962691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, Shin‐Meng</creatorcontrib><creatorcontrib>Chen, Chia‐Jung</creatorcontrib><creatorcontrib>Lin, Hung‐Lung</creatorcontrib><creatorcontrib>Cheng, Irene H.</creatorcontrib><title>The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation</title><title>IUBMB life</title><addtitle>IUBMB Life</addtitle><description>Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. 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AD‐like deficits were reduced in mice treated with synbiotics, suggesting that dietary modulation of the gut–brain axis is a potential approach to delay AD progression.</description><subject>Alzheimer's disease</subject><subject>Amyloid</subject><subject>Cognitive ability</subject><subject>Inflammation</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>neuroinflammation</subject><subject>synbiotics</subject><issn>1521-6543</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kclKBDEQhoMozriATyABD3ppTTrTS46juIHgRc8hna5ohixjp1sZL766aTdEMIRUDh9f_VQhtEfJMSUkPzFDc5wXNV9DU1rkNCuLgq7__GdsgrZiXJB0KsI30YTNeJmXnE7R290j4AY8aKOMtBi0BtXjoHFc-caE3qiIVfBxcMveBI_TndvXRzAOusOIWxNBRsAuDB9vCxY_G4k7aAdl_AO2QSWt9G0Sxh6cUdh4baVzcvTtoA0tbYTdr7qN7i_O786uspvby-uz-U2mUlae1UTTOmVnjKqCtmymq0ZrJnlDWiiAVm0OBAjnKb-EgjCWl7XkdV2xYpwQ20ZHn95lF54GiL1wJiqwVnpI0UVe0gRyxquEHvxBF2HofEonxpnVqUv1S6i6EGMHWiw742S3EpSIsaVISxHjUhK6_yUcGgftD_i9hQRkn8CLsbD6VySu708_hO99_ZZ1</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Deng, Shin‐Meng</creator><creator>Chen, Chia‐Jung</creator><creator>Lin, Hung‐Lung</creator><creator>Cheng, Irene H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3737-3877</orcidid><orcidid>https://orcid.org/0000-0002-6739-5452</orcidid></search><sort><creationdate>202208</creationdate><title>The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation</title><author>Deng, Shin‐Meng ; Chen, Chia‐Jung ; Lin, Hung‐Lung ; Cheng, Irene H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3499-80f18709331c51d34f7bff3a9b0de5e17d2e0e099effae5033268a98873510023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alzheimer's disease</topic><topic>Amyloid</topic><topic>Cognitive ability</topic><topic>Inflammation</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>neuroinflammation</topic><topic>synbiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, Shin‐Meng</creatorcontrib><creatorcontrib>Chen, Chia‐Jung</creatorcontrib><creatorcontrib>Lin, Hung‐Lung</creatorcontrib><creatorcontrib>Cheng, Irene H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>IUBMB life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, Shin‐Meng</au><au>Chen, Chia‐Jung</au><au>Lin, Hung‐Lung</au><au>Cheng, Irene H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation</atitle><jtitle>IUBMB life</jtitle><addtitle>IUBMB Life</addtitle><date>2022-08</date><risdate>2022</risdate><volume>74</volume><issue>8</issue><spage>748</spage><epage>753</epage><pages>748-753</pages><issn>1521-6543</issn><eissn>1521-6551</eissn><abstract>Alzheimer's disease (AD) is a neurodegenerative disease that impairs multiple memory domains without an effective prevention or treatment approach. 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subjects	Alzheimer's disease Amyloid Cognitive ability Inflammation Neurodegeneration Neurodegenerative diseases neuroinflammation synbiotics
title	The beneficial effect of synbiotics consumption on Alzheimer's disease mouse model via reducing local and systemic inflammation
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