Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study
Purpose To compare sentinel lymph node (SLN) identification using [ 68 Ga]Ga-tilmanocept PET/CT lymphoscintigraphy to [ 99m Tc]Tc-tilmanocept lymphoscintigraphy (including SPECT/CT) in early-stage oral cancer. Furthermore, to assess whether reliable intraoperative SLN localization can be performed w...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2022-05, Vol.49 (6), p.2023-2036 |
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| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 49 |
| creator | Mahieu, Rutger Donders, Dominique N. V. Krijger, Gerard C. Ververs, F. F. Tessa de Roos, Remmert Bemelmans, John L. M. M. van Rooij, Rob de Bree, Remco de Keizer, Bart |
| description | Purpose
To compare sentinel lymph node (SLN) identification using [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy (including SPECT/CT) in early-stage oral cancer. Furthermore, to assess whether reliable intraoperative SLN localization can be performed with a conventional portable gamma-probe using [
99m
Tc]Tc-tilmanocept without the interference of [
68
Ga]Ga-tilmanocept in these patients.
Methods
This prospective within-patient comparison pilot study evaluated SLN identification by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy compared to conventional lymphoscintigraphy using [
99m
Tc]Tc-tilmanocept (~ 74 MBq) in 10 early-stage oral cancer patients scheduled for SLN biopsy. After conventional [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, patients underwent peritumoral administration of [
68
Ga]Ga-tilmanocept (~ 10 MBq) followed by PET/CT acquisition initiated 15 min after injection. Intraoperative SLN localization was performed under conventional portable gamma-probe guidance the next day; the location of harvested SLNs was correlated to both lymphoscintigraphic images in each patient.
Results
A total of 24 SLNs were identified by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, all except one were also identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy. [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy identified 4 additional SLNs near the injection site, of which two harbored metastases. Lymphatic vessels transporting [
68
Ga]Ga-tilmanocept were identified by PET/CT lymphoscintigraphy in 80% of patients, while draining lymphatic vessels were visualized by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy in 20% of patients. Of the 33 SLNs identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy, 30 (91%) were intraoperatively localized under conventional gamma-probe guidance.
Conclusion
[
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy provided more accurate identification of SLNs and improved visualization of lymphatic vessels compared to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy. When combined with peritumoral administration of [
99m
Tc]Tc-tilmanocept, SLNs detected by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy can be reliably localized during surgery under conventional gamma-probe guidance. |
| doi_str_mv | 10.1007/s00259-021-05645-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2615109209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2651902122</sourcerecordid><originalsourceid>FETCH-LOGICAL-c441t-20734980aeed67d83e046ac5d25f53813c06f541ef308c3498a2b8f2797b1433</originalsourceid><addsrcrecordid>eNp9kd-K1TAQxoso7h99AS8k4I03cSdp0ybeyWE9KyzoRcGLZSk56XRPljapScpyHs53M2vXFUW8moH5fd_M8BXFKwbvGEBzFgG4UBQ4oyDqSlB4UhyzminagFRPH_sGjoqTGG8BmORSPS-OykrVXEh-XHz_atPeOjrrZNElYvw062Cjd2SH6Q7RkatabvX1VtNkx0k7b3BO5Mt5e7ZpyXiY5r2Pxrpkb4Ke9weiXU-ulJpac92aPzT_gAcfSMx7rcNxnRPneyQ9JjTJ5iusIz7okRjtDIb3RJPZjj6RmJb-8KJ4Nugx4suHelq0H8_bzQW9_Lz9tPlwSU1VsUQ5NPljCRqxr5telghVrY3ouRhEKVlpoB5ExXAoQZp7VPOdHHijmh2ryvK0eLvazsF_WzCmbrLR4Dhqh36JHa-ZYKA4qIy--Qu99Utw-bhMCaZyWJxniq-UCT7GgEM3BzvpcOgYdPfZdmu2Xca7n9l2kEWvH6yX3YT9o-RXmBkoVyDmkbvB8Hv3f2x_AFX6sgU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2651902122</pqid></control><display><type>article</type><title>Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Mahieu, Rutger ; Donders, Dominique N. V. ; Krijger, Gerard C. ; Ververs, F. F. Tessa ; de Roos, Remmert ; Bemelmans, John L. M. M. ; van Rooij, Rob ; de Bree, Remco ; de Keizer, Bart</creator><creatorcontrib>Mahieu, Rutger ; Donders, Dominique N. V. ; Krijger, Gerard C. ; Ververs, F. F. Tessa ; de Roos, Remmert ; Bemelmans, John L. M. M. ; van Rooij, Rob ; de Bree, Remco ; de Keizer, Bart</creatorcontrib><description>Purpose
To compare sentinel lymph node (SLN) identification using [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy (including SPECT/CT) in early-stage oral cancer. Furthermore, to assess whether reliable intraoperative SLN localization can be performed with a conventional portable gamma-probe using [
99m
Tc]Tc-tilmanocept without the interference of [
68
Ga]Ga-tilmanocept in these patients.
Methods
This prospective within-patient comparison pilot study evaluated SLN identification by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy compared to conventional lymphoscintigraphy using [
99m
Tc]Tc-tilmanocept (~ 74 MBq) in 10 early-stage oral cancer patients scheduled for SLN biopsy. After conventional [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, patients underwent peritumoral administration of [
68
Ga]Ga-tilmanocept (~ 10 MBq) followed by PET/CT acquisition initiated 15 min after injection. Intraoperative SLN localization was performed under conventional portable gamma-probe guidance the next day; the location of harvested SLNs was correlated to both lymphoscintigraphic images in each patient.
Results
A total of 24 SLNs were identified by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, all except one were also identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy. [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy identified 4 additional SLNs near the injection site, of which two harbored metastases. Lymphatic vessels transporting [
68
Ga]Ga-tilmanocept were identified by PET/CT lymphoscintigraphy in 80% of patients, while draining lymphatic vessels were visualized by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy in 20% of patients. Of the 33 SLNs identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy, 30 (91%) were intraoperatively localized under conventional gamma-probe guidance.
Conclusion
[
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy provided more accurate identification of SLNs and improved visualization of lymphatic vessels compared to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy. When combined with peritumoral administration of [
99m
Tc]Tc-tilmanocept, SLNs detected by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy can be reliably localized during surgery under conventional gamma-probe guidance.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-021-05645-0</identifier><identifier>PMID: 34962582</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biopsy ; Cancer ; Cardiology ; Dextrans ; Gallium Radioisotopes ; Humans ; Imaging ; Injection ; Localization ; Lymph nodes ; Lymph Nodes - pathology ; Lymphatic system ; Lymphoscintigraphy - methods ; Mannans ; Medicine ; Medicine & Public Health ; Metastases ; Mouth Neoplasms - pathology ; Nuclear Medicine ; Oncology ; Oral cancer ; Original Article ; Orthopedics ; Patients ; Pilot Projects ; Portability ; Positron emission ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Radiology ; Radiopharmaceuticals ; Sentinel Lymph Node - diagnostic imaging ; Sentinel Lymph Node - pathology ; Sentinel Lymph Node Biopsy - methods ; Single photon emission computed tomography ; Technetium Tc 99m Pentetate ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2022-05, Vol.49 (6), p.2023-2036</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-20734980aeed67d83e046ac5d25f53813c06f541ef308c3498a2b8f2797b1433</citedby><cites>FETCH-LOGICAL-c441t-20734980aeed67d83e046ac5d25f53813c06f541ef308c3498a2b8f2797b1433</cites><orcidid>0000-0002-8518-4659 ; 0000-0001-7128-5814 ; 0000-0001-8546-8283 ; 0000-0001-9359-8205 ; 0000-0002-5533-8565 ; 0000-0001-9467-023X ; 0000-0002-6270-9483</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00259-021-05645-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00259-021-05645-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34962582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahieu, Rutger</creatorcontrib><creatorcontrib>Donders, Dominique N. V.</creatorcontrib><creatorcontrib>Krijger, Gerard C.</creatorcontrib><creatorcontrib>Ververs, F. F. Tessa</creatorcontrib><creatorcontrib>de Roos, Remmert</creatorcontrib><creatorcontrib>Bemelmans, John L. M. M.</creatorcontrib><creatorcontrib>van Rooij, Rob</creatorcontrib><creatorcontrib>de Bree, Remco</creatorcontrib><creatorcontrib>de Keizer, Bart</creatorcontrib><title>Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Purpose
To compare sentinel lymph node (SLN) identification using [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy (including SPECT/CT) in early-stage oral cancer. Furthermore, to assess whether reliable intraoperative SLN localization can be performed with a conventional portable gamma-probe using [
99m
Tc]Tc-tilmanocept without the interference of [
68
Ga]Ga-tilmanocept in these patients.
Methods
This prospective within-patient comparison pilot study evaluated SLN identification by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy compared to conventional lymphoscintigraphy using [
99m
Tc]Tc-tilmanocept (~ 74 MBq) in 10 early-stage oral cancer patients scheduled for SLN biopsy. After conventional [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, patients underwent peritumoral administration of [
68
Ga]Ga-tilmanocept (~ 10 MBq) followed by PET/CT acquisition initiated 15 min after injection. Intraoperative SLN localization was performed under conventional portable gamma-probe guidance the next day; the location of harvested SLNs was correlated to both lymphoscintigraphic images in each patient.
Results
A total of 24 SLNs were identified by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, all except one were also identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy. [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy identified 4 additional SLNs near the injection site, of which two harbored metastases. Lymphatic vessels transporting [
68
Ga]Ga-tilmanocept were identified by PET/CT lymphoscintigraphy in 80% of patients, while draining lymphatic vessels were visualized by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy in 20% of patients. Of the 33 SLNs identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy, 30 (91%) were intraoperatively localized under conventional gamma-probe guidance.
Conclusion
[
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy provided more accurate identification of SLNs and improved visualization of lymphatic vessels compared to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy. When combined with peritumoral administration of [
99m
Tc]Tc-tilmanocept, SLNs detected by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy can be reliably localized during surgery under conventional gamma-probe guidance.</description><subject>Biopsy</subject><subject>Cancer</subject><subject>Cardiology</subject><subject>Dextrans</subject><subject>Gallium Radioisotopes</subject><subject>Humans</subject><subject>Imaging</subject><subject>Injection</subject><subject>Localization</subject><subject>Lymph nodes</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic system</subject><subject>Lymphoscintigraphy - methods</subject><subject>Mannans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Mouth Neoplasms - pathology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Oral cancer</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Patients</subject><subject>Pilot Projects</subject><subject>Portability</subject><subject>Positron emission</subject><subject>Positron Emission Tomography Computed Tomography</subject><subject>Prospective Studies</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Sentinel Lymph Node - diagnostic imaging</subject><subject>Sentinel Lymph Node - pathology</subject><subject>Sentinel Lymph Node Biopsy - methods</subject><subject>Single photon emission computed tomography</subject><subject>Technetium Tc 99m Pentetate</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kd-K1TAQxoso7h99AS8k4I03cSdp0ybeyWE9KyzoRcGLZSk56XRPljapScpyHs53M2vXFUW8moH5fd_M8BXFKwbvGEBzFgG4UBQ4oyDqSlB4UhyzminagFRPH_sGjoqTGG8BmORSPS-OykrVXEh-XHz_atPeOjrrZNElYvw062Cjd2SH6Q7RkatabvX1VtNkx0k7b3BO5Mt5e7ZpyXiY5r2Pxrpkb4Ke9weiXU-ulJpac92aPzT_gAcfSMx7rcNxnRPneyQ9JjTJ5iusIz7okRjtDIb3RJPZjj6RmJb-8KJ4Nugx4suHelq0H8_bzQW9_Lz9tPlwSU1VsUQ5NPljCRqxr5telghVrY3ouRhEKVlpoB5ExXAoQZp7VPOdHHijmh2ryvK0eLvazsF_WzCmbrLR4Dhqh36JHa-ZYKA4qIy--Qu99Utw-bhMCaZyWJxniq-UCT7GgEM3BzvpcOgYdPfZdmu2Xca7n9l2kEWvH6yX3YT9o-RXmBkoVyDmkbvB8Hv3f2x_AFX6sgU</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Mahieu, Rutger</creator><creator>Donders, Dominique N. V.</creator><creator>Krijger, Gerard C.</creator><creator>Ververs, F. F. Tessa</creator><creator>de Roos, Remmert</creator><creator>Bemelmans, John L. M. M.</creator><creator>van Rooij, Rob</creator><creator>de Bree, Remco</creator><creator>de Keizer, Bart</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8518-4659</orcidid><orcidid>https://orcid.org/0000-0001-7128-5814</orcidid><orcidid>https://orcid.org/0000-0001-8546-8283</orcidid><orcidid>https://orcid.org/0000-0001-9359-8205</orcidid><orcidid>https://orcid.org/0000-0002-5533-8565</orcidid><orcidid>https://orcid.org/0000-0001-9467-023X</orcidid><orcidid>https://orcid.org/0000-0002-6270-9483</orcidid></search><sort><creationdate>202205</creationdate><title>Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study</title><author>Mahieu, Rutger ; Donders, Dominique N. V. ; Krijger, Gerard C. ; Ververs, F. F. Tessa ; de Roos, Remmert ; Bemelmans, John L. M. M. ; van Rooij, Rob ; de Bree, Remco ; de Keizer, Bart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-20734980aeed67d83e046ac5d25f53813c06f541ef308c3498a2b8f2797b1433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biopsy</topic><topic>Cancer</topic><topic>Cardiology</topic><topic>Dextrans</topic><topic>Gallium Radioisotopes</topic><topic>Humans</topic><topic>Imaging</topic><topic>Injection</topic><topic>Localization</topic><topic>Lymph nodes</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic system</topic><topic>Lymphoscintigraphy - methods</topic><topic>Mannans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Mouth Neoplasms - pathology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Oral cancer</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Patients</topic><topic>Pilot Projects</topic><topic>Portability</topic><topic>Positron emission</topic><topic>Positron Emission Tomography Computed Tomography</topic><topic>Prospective Studies</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Sentinel Lymph Node - diagnostic imaging</topic><topic>Sentinel Lymph Node - pathology</topic><topic>Sentinel Lymph Node Biopsy - methods</topic><topic>Single photon emission computed tomography</topic><topic>Technetium Tc 99m Pentetate</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahieu, Rutger</creatorcontrib><creatorcontrib>Donders, Dominique N. V.</creatorcontrib><creatorcontrib>Krijger, Gerard C.</creatorcontrib><creatorcontrib>Ververs, F. F. Tessa</creatorcontrib><creatorcontrib>de Roos, Remmert</creatorcontrib><creatorcontrib>Bemelmans, John L. M. M.</creatorcontrib><creatorcontrib>van Rooij, Rob</creatorcontrib><creatorcontrib>de Bree, Remco</creatorcontrib><creatorcontrib>de Keizer, Bart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahieu, Rutger</au><au>Donders, Dominique N. V.</au><au>Krijger, Gerard C.</au><au>Ververs, F. F. Tessa</au><au>de Roos, Remmert</au><au>Bemelmans, John L. M. M.</au><au>van Rooij, Rob</au><au>de Bree, Remco</au><au>de Keizer, Bart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><stitle>Eur J Nucl Med Mol Imaging</stitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2022-05</date><risdate>2022</risdate><volume>49</volume><issue>6</issue><spage>2023</spage><epage>2036</epage><pages>2023-2036</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose
To compare sentinel lymph node (SLN) identification using [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy (including SPECT/CT) in early-stage oral cancer. Furthermore, to assess whether reliable intraoperative SLN localization can be performed with a conventional portable gamma-probe using [
99m
Tc]Tc-tilmanocept without the interference of [
68
Ga]Ga-tilmanocept in these patients.
Methods
This prospective within-patient comparison pilot study evaluated SLN identification by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy compared to conventional lymphoscintigraphy using [
99m
Tc]Tc-tilmanocept (~ 74 MBq) in 10 early-stage oral cancer patients scheduled for SLN biopsy. After conventional [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, patients underwent peritumoral administration of [
68
Ga]Ga-tilmanocept (~ 10 MBq) followed by PET/CT acquisition initiated 15 min after injection. Intraoperative SLN localization was performed under conventional portable gamma-probe guidance the next day; the location of harvested SLNs was correlated to both lymphoscintigraphic images in each patient.
Results
A total of 24 SLNs were identified by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy, all except one were also identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy. [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy identified 4 additional SLNs near the injection site, of which two harbored metastases. Lymphatic vessels transporting [
68
Ga]Ga-tilmanocept were identified by PET/CT lymphoscintigraphy in 80% of patients, while draining lymphatic vessels were visualized by [
99m
Tc]Tc-tilmanocept lymphoscintigraphy in 20% of patients. Of the 33 SLNs identified by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy, 30 (91%) were intraoperatively localized under conventional gamma-probe guidance.
Conclusion
[
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy provided more accurate identification of SLNs and improved visualization of lymphatic vessels compared to [
99m
Tc]Tc-tilmanocept lymphoscintigraphy. When combined with peritumoral administration of [
99m
Tc]Tc-tilmanocept, SLNs detected by [
68
Ga]Ga-tilmanocept PET/CT lymphoscintigraphy can be reliably localized during surgery under conventional gamma-probe guidance.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34962582</pmid><doi>10.1007/s00259-021-05645-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8518-4659</orcidid><orcidid>https://orcid.org/0000-0001-7128-5814</orcidid><orcidid>https://orcid.org/0000-0001-8546-8283</orcidid><orcidid>https://orcid.org/0000-0001-9359-8205</orcidid><orcidid>https://orcid.org/0000-0002-5533-8565</orcidid><orcidid>https://orcid.org/0000-0001-9467-023X</orcidid><orcidid>https://orcid.org/0000-0002-6270-9483</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1619-7070 |
| ispartof | European journal of nuclear medicine and molecular imaging, 2022-05, Vol.49 (6), p.2023-2036 |
| issn | 1619-7070 1619-7089 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2615109209 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biopsy Cancer Cardiology Dextrans Gallium Radioisotopes Humans Imaging Injection Localization Lymph nodes Lymph Nodes - pathology Lymphatic system Lymphoscintigraphy - methods Mannans Medicine Medicine & Public Health Metastases Mouth Neoplasms - pathology Nuclear Medicine Oncology Oral cancer Original Article Orthopedics Patients Pilot Projects Portability Positron emission Positron Emission Tomography Computed Tomography Prospective Studies Radiology Radiopharmaceuticals Sentinel Lymph Node - diagnostic imaging Sentinel Lymph Node - pathology Sentinel Lymph Node Biopsy - methods Single photon emission computed tomography Technetium Tc 99m Pentetate Tomography |
| title | Within-patient comparison between [68Ga]Ga-tilmanocept PET/CT lymphoscintigraphy and [99mTc]Tc-tilmanocept lymphoscintigraphy for sentinel lymph node detection in oral cancer: a pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T19%3A51%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Within-patient%20comparison%20between%20%5B68Ga%5DGa-tilmanocept%20PET/CT%20lymphoscintigraphy%20and%20%5B99mTc%5DTc-tilmanocept%20lymphoscintigraphy%20for%20sentinel%20lymph%20node%20detection%20in%20oral%20cancer:%20a%20pilot%20study&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Mahieu,%20Rutger&rft.date=2022-05&rft.volume=49&rft.issue=6&rft.spage=2023&rft.epage=2036&rft.pages=2023-2036&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-021-05645-0&rft_dat=%3Cproquest_cross%3E2651902122%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2651902122&rft_id=info:pmid/34962582&rfr_iscdi=true |