Feasible and clinical relevant outcome measures for adults with mitochondrial disease
There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients...
Gespeichert in:
| Veröffentlicht in: | Molecular genetics and metabolism 2022-01, Vol.135 (1), p.102-108 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 108 |
|---|---|
| container_issue | 1 |
| container_start_page | 102 |
| container_title | Molecular genetics and metabolism |
| container_volume | 135 |
| creator | Bergs, Peggy M.J. Maas, Daphne M. Janssen, Mirian C.H. Groothuis, Jan T. |
| description | There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients with MD, endurance, balance, strength and mobility tests were evaluated. All tests showed a negative deviation to healthy reference values. Balance tests were feasible and significantly correlated with clinical severity. The Åstrand cycle test was not feasible in 55%, whereas the feasibility of the 6 min walking test is unclear in patients with MD. |
| doi_str_mv | 10.1016/j.ymgme.2021.12.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2615108962</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1096719221011951</els_id><sourcerecordid>2615108962</sourcerecordid><originalsourceid>FETCH-LOGICAL-c354t-fc23f97b03e0f4f90ca8cd3a09ef520b7f95461377f32fe57a8515b74920e2d43</originalsourceid><addsrcrecordid>eNp9kD1v2zAQhoWiRZO4_QUBAo5ZrN6R-uKQIQiSNoCBLu1MUOSxpiGJDik58L8vUycZO90Nz3sv7imKS4QSAZtvu_I4_hmp5MCxRF4CwofiHEE265ZD8_FtR8nPiouUdgCItaw-F2eikg02XXde_H4gnXw_ENOTZWbwkzd6YJEGOuhpZmGZTRiJjRlbIiXmQmTaLsOc2LOft2z0czDbMNnoc876lEH6Unxyekj09XWucs_9r7sf683P7493t5u1EXU1r53hwsm2B0HgKifB6M5YoUGSqzn0rZN11aBoWye4o7rVXY1131aSA3FbiVVxfbq7j-FpoTSr0SdDw6AnCktSvMEaoZMNz6g4oSaGlCI5tY9-1PGoENSLT7VT_3yqF58Kuco-c-rqtWDpR7LvmTeBGbg5AZTfPHiKKhlPkyHrI5lZ2eD_W_AXOFuIVw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2615108962</pqid></control><display><type>article</type><title>Feasible and clinical relevant outcome measures for adults with mitochondrial disease</title><source>Access via ScienceDirect (Elsevier)</source><creator>Bergs, Peggy M.J. ; Maas, Daphne M. ; Janssen, Mirian C.H. ; Groothuis, Jan T.</creator><creatorcontrib>Bergs, Peggy M.J. ; Maas, Daphne M. ; Janssen, Mirian C.H. ; Groothuis, Jan T.</creatorcontrib><description>There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients with MD, endurance, balance, strength and mobility tests were evaluated. All tests showed a negative deviation to healthy reference values. Balance tests were feasible and significantly correlated with clinical severity. The Åstrand cycle test was not feasible in 55%, whereas the feasibility of the 6 min walking test is unclear in patients with MD.</description><identifier>ISSN: 1096-7192</identifier><identifier>EISSN: 1096-7206</identifier><identifier>DOI: 10.1016/j.ymgme.2021.12.010</identifier><identifier>PMID: 34961688</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adults ; Mitochondrial disease ; Outcome measures ; Physical therapy</subject><ispartof>Molecular genetics and metabolism, 2022-01, Vol.135 (1), p.102-108</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c354t-fc23f97b03e0f4f90ca8cd3a09ef520b7f95461377f32fe57a8515b74920e2d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ymgme.2021.12.010$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34961688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bergs, Peggy M.J.</creatorcontrib><creatorcontrib>Maas, Daphne M.</creatorcontrib><creatorcontrib>Janssen, Mirian C.H.</creatorcontrib><creatorcontrib>Groothuis, Jan T.</creatorcontrib><title>Feasible and clinical relevant outcome measures for adults with mitochondrial disease</title><title>Molecular genetics and metabolism</title><addtitle>Mol Genet Metab</addtitle><description>There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients with MD, endurance, balance, strength and mobility tests were evaluated. All tests showed a negative deviation to healthy reference values. Balance tests were feasible and significantly correlated with clinical severity. The Åstrand cycle test was not feasible in 55%, whereas the feasibility of the 6 min walking test is unclear in patients with MD.</description><subject>Adults</subject><subject>Mitochondrial disease</subject><subject>Outcome measures</subject><subject>Physical therapy</subject><issn>1096-7192</issn><issn>1096-7206</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kD1v2zAQhoWiRZO4_QUBAo5ZrN6R-uKQIQiSNoCBLu1MUOSxpiGJDik58L8vUycZO90Nz3sv7imKS4QSAZtvu_I4_hmp5MCxRF4CwofiHEE265ZD8_FtR8nPiouUdgCItaw-F2eikg02XXde_H4gnXw_ENOTZWbwkzd6YJEGOuhpZmGZTRiJjRlbIiXmQmTaLsOc2LOft2z0czDbMNnoc876lEH6Unxyekj09XWucs_9r7sf683P7493t5u1EXU1r53hwsm2B0HgKifB6M5YoUGSqzn0rZN11aBoWye4o7rVXY1131aSA3FbiVVxfbq7j-FpoTSr0SdDw6AnCktSvMEaoZMNz6g4oSaGlCI5tY9-1PGoENSLT7VT_3yqF58Kuco-c-rqtWDpR7LvmTeBGbg5AZTfPHiKKhlPkyHrI5lZ2eD_W_AXOFuIVw</recordid><startdate>202201</startdate><enddate>202201</enddate><creator>Bergs, Peggy M.J.</creator><creator>Maas, Daphne M.</creator><creator>Janssen, Mirian C.H.</creator><creator>Groothuis, Jan T.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202201</creationdate><title>Feasible and clinical relevant outcome measures for adults with mitochondrial disease</title><author>Bergs, Peggy M.J. ; Maas, Daphne M. ; Janssen, Mirian C.H. ; Groothuis, Jan T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-fc23f97b03e0f4f90ca8cd3a09ef520b7f95461377f32fe57a8515b74920e2d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adults</topic><topic>Mitochondrial disease</topic><topic>Outcome measures</topic><topic>Physical therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bergs, Peggy M.J.</creatorcontrib><creatorcontrib>Maas, Daphne M.</creatorcontrib><creatorcontrib>Janssen, Mirian C.H.</creatorcontrib><creatorcontrib>Groothuis, Jan T.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular genetics and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bergs, Peggy M.J.</au><au>Maas, Daphne M.</au><au>Janssen, Mirian C.H.</au><au>Groothuis, Jan T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasible and clinical relevant outcome measures for adults with mitochondrial disease</atitle><jtitle>Molecular genetics and metabolism</jtitle><addtitle>Mol Genet Metab</addtitle><date>2022-01</date><risdate>2022</risdate><volume>135</volume><issue>1</issue><spage>102</spage><epage>108</epage><pages>102-108</pages><issn>1096-7192</issn><eissn>1096-7206</eissn><abstract>There is no consensus on clinical outcome measures that reflect function, activities and participation which are suitable for adults with mitochondrial diseases (MD). The aim of this study was to determine feasible and clinically relevant outcome measures for patients with MD . In 156 adult patients with MD, endurance, balance, strength and mobility tests were evaluated. All tests showed a negative deviation to healthy reference values. Balance tests were feasible and significantly correlated with clinical severity. The Åstrand cycle test was not feasible in 55%, whereas the feasibility of the 6 min walking test is unclear in patients with MD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34961688</pmid><doi>10.1016/j.ymgme.2021.12.010</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1096-7192 |
| ispartof | Molecular genetics and metabolism, 2022-01, Vol.135 (1), p.102-108 |
| issn | 1096-7192 1096-7206 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2615108962 |
| source | Access via ScienceDirect (Elsevier) |
| subjects | Adults Mitochondrial disease Outcome measures Physical therapy |
| title | Feasible and clinical relevant outcome measures for adults with mitochondrial disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T12%3A42%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Feasible%20and%20clinical%20relevant%20outcome%20measures%20for%20adults%20with%20mitochondrial%20disease&rft.jtitle=Molecular%20genetics%20and%20metabolism&rft.au=Bergs,%20Peggy%20M.J.&rft.date=2022-01&rft.volume=135&rft.issue=1&rft.spage=102&rft.epage=108&rft.pages=102-108&rft.issn=1096-7192&rft.eissn=1096-7206&rft_id=info:doi/10.1016/j.ymgme.2021.12.010&rft_dat=%3Cproquest_cross%3E2615108962%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2615108962&rft_id=info:pmid/34961688&rft_els_id=S1096719221011951&rfr_iscdi=true |