Mapping the conformational epitope of a therapeutic monoclonal antibody against HBsAg by in vivo selection of HBV escape variants

Background and Aims Hepatitis B immunoglobulin (HBIG) has been routinely applied in the liver transplantation setting to block HBV reinfection of grafts. However, new monoclonal anti‐HBV surface antibodies have been developed to replace HBIG. The epitopes of such monoclonal antibodies may affect the...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2022-07, Vol.76 (1), p.207-219
Hauptverfasser:	Wu, Chang‐Ru, Kim, Hyun‐Jin, Sun, Cheng‐Pu, Chung, Chen‐Yen, Lin, You‐Yu, Tao, Mi‐Hua, Kim, Jung‐Hwan, Chen, Ding‐Shinn, Chen, Pei‐Jer
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Cell culture Epitope mapping Hepatitis B Hepatitis B surface antigen Hepatology Liver transplantation Monoclonal antibodies
Online-Zugang:	Volltext
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