PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor...
Gespeichert in:
Veröffentlicht in: | Cancer biomarkers : section A of Disease markers 2022-01, Vol.34 (2), p.251-264 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 264 |
---|---|
container_issue | 2 |
container_start_page | 251 |
container_title | Cancer biomarkers : section A of Disease markers |
container_volume | 34 |
creator | Liu, Baohong Xiao, Xingxing Lin, Ziqin Lou, Yongliang Zhao, Lingling |
description | Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor-
β
(PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets. |
doi_str_mv | 10.3233/CBM-210335 |
format | Article |
fullrecord | <record><control><sourceid>proquest_AFRWT</sourceid><recordid>TN_cdi_proquest_miscellaneous_2614753927</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.3233_CBM-210335</sage_id><sourcerecordid>2667821197</sourcerecordid><originalsourceid>FETCH-LOGICAL-c277t-367445da9116e1434f5b4a822333ca46addf7e3f284f98838feacb00dd48e4013</originalsourceid><addsrcrecordid>eNptkMlKBDEQhoMo7hcfQAIeFKE1ayd9dMYVFEX03GTS1WO0lzFJI769GWZUEE8pwld_VX0I7VFywhnnp-PRXcYo4VyuoE2qlcy0LNhqqqUSGaGSb6CtEF4JEZyyYh1tcFFITQjdRPbh_OrycYRdwAbP-ghddKbBM99Puz5EZ_HE9a3xb-Cx6Spse--hMREq_OHiC3ZtO3SAXVe7Jvr0H1KNpyZEn3qt6Sz4HbRWmybA7vLdRs-XF0_j6-z2_upmfHabWaZUzHiuhJCVKSjNgQouajkRRrN0IrdG5KaqagW8ZlrUhdZc12DshJCqEhoEoXwbHS1y0_bvA4RYti5YaBrTQT-EkuVUKMkLphJ68Ad97Qffpe0SlSvNKC3m1PGCsr4PwUNdzrxLMj5LSsq5-jKpLxfqE7y_jBwmLVQ_6LfrBBwugGCm8Dvvn6gv3UaJhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2667821197</pqid></control><display><type>article</type><title>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</title><source>Sage Journals GOLD Open Access 2024</source><creator>Liu, Baohong ; Xiao, Xingxing ; Lin, Ziqin ; Lou, Yongliang ; Zhao, Lingling</creator><creatorcontrib>Liu, Baohong ; Xiao, Xingxing ; Lin, Ziqin ; Lou, Yongliang ; Zhao, Lingling</creatorcontrib><description>Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor-
β
(PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-210335</identifier><identifier>PMID: 34958001</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Algorithms ; Angiogenesis ; Biomarkers ; Cancer ; Cell proliferation ; Gastric cancer ; Growth factors ; Immune system ; Infiltration ; Macrophages ; Metastases ; Microenvironments ; Morbidity ; Platelet-derived growth factor ; Platelet-derived growth factor receptors ; Prognosis ; Tumors</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2022-01, Vol.34 (2), p.251-264</ispartof><rights>2022 – IOS Press. All rights reserved.</rights><rights>Copyright IOS Press BV 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-367445da9116e1434f5b4a822333ca46addf7e3f284f98838feacb00dd48e4013</citedby><cites>FETCH-LOGICAL-c277t-367445da9116e1434f5b4a822333ca46addf7e3f284f98838feacb00dd48e4013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.3233/CBM-210335$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.3233/CBM-210335$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21946,27832,27903,27904,44924,45312</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.3233/CBM-210335?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34958001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Baohong</creatorcontrib><creatorcontrib>Xiao, Xingxing</creatorcontrib><creatorcontrib>Lin, Ziqin</creatorcontrib><creatorcontrib>Lou, Yongliang</creatorcontrib><creatorcontrib>Zhao, Lingling</creatorcontrib><title>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</title><title>Cancer biomarkers : section A of Disease markers</title><addtitle>Cancer Biomark</addtitle><description>Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor-
β
(PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</description><subject>Algorithms</subject><subject>Angiogenesis</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cell proliferation</subject><subject>Gastric cancer</subject><subject>Growth factors</subject><subject>Immune system</subject><subject>Infiltration</subject><subject>Macrophages</subject><subject>Metastases</subject><subject>Microenvironments</subject><subject>Morbidity</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor receptors</subject><subject>Prognosis</subject><subject>Tumors</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptkMlKBDEQhoMo7hcfQAIeFKE1ayd9dMYVFEX03GTS1WO0lzFJI769GWZUEE8pwld_VX0I7VFywhnnp-PRXcYo4VyuoE2qlcy0LNhqqqUSGaGSb6CtEF4JEZyyYh1tcFFITQjdRPbh_OrycYRdwAbP-ghddKbBM99Puz5EZ_HE9a3xb-Cx6Spse--hMREq_OHiC3ZtO3SAXVe7Jvr0H1KNpyZEn3qt6Sz4HbRWmybA7vLdRs-XF0_j6-z2_upmfHabWaZUzHiuhJCVKSjNgQouajkRRrN0IrdG5KaqagW8ZlrUhdZc12DshJCqEhoEoXwbHS1y0_bvA4RYti5YaBrTQT-EkuVUKMkLphJ68Ad97Qffpe0SlSvNKC3m1PGCsr4PwUNdzrxLMj5LSsq5-jKpLxfqE7y_jBwmLVQ_6LfrBBwugGCm8Dvvn6gv3UaJhw</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Liu, Baohong</creator><creator>Xiao, Xingxing</creator><creator>Lin, Ziqin</creator><creator>Lou, Yongliang</creator><creator>Zhao, Lingling</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</title><author>Liu, Baohong ; Xiao, Xingxing ; Lin, Ziqin ; Lou, Yongliang ; Zhao, Lingling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-367445da9116e1434f5b4a822333ca46addf7e3f284f98838feacb00dd48e4013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Algorithms</topic><topic>Angiogenesis</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cell proliferation</topic><topic>Gastric cancer</topic><topic>Growth factors</topic><topic>Immune system</topic><topic>Infiltration</topic><topic>Macrophages</topic><topic>Metastases</topic><topic>Microenvironments</topic><topic>Morbidity</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor receptors</topic><topic>Prognosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Baohong</creatorcontrib><creatorcontrib>Xiao, Xingxing</creatorcontrib><creatorcontrib>Lin, Ziqin</creatorcontrib><creatorcontrib>Lou, Yongliang</creatorcontrib><creatorcontrib>Zhao, Lingling</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Baohong</au><au>Xiao, Xingxing</au><au>Lin, Ziqin</au><au>Lou, Yongliang</au><au>Zhao, Lingling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>34</volume><issue>2</issue><spage>251</spage><epage>264</epage><pages>251-264</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor-
β
(PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>34958001</pmid><doi>10.3233/CBM-210335</doi><tpages>14</tpages></addata></record> |
fulltext | fulltext_linktorsrc |
identifier | ISSN: 1574-0153 |
ispartof | Cancer biomarkers : section A of Disease markers, 2022-01, Vol.34 (2), p.251-264 |
issn | 1574-0153 1875-8592 |
language | eng |
recordid | cdi_proquest_miscellaneous_2614753927 |
source | Sage Journals GOLD Open Access 2024 |
subjects | Algorithms Angiogenesis Biomarkers Cancer Cell proliferation Gastric cancer Growth factors Immune system Infiltration Macrophages Metastases Microenvironments Morbidity Platelet-derived growth factor Platelet-derived growth factor receptors Prognosis Tumors |
title | PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T08%3A52%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_AFRWT&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PDGFRB%20is%20a%20potential%20prognostic%20biomarker%20and%20correlated%20with%20immune%20infiltrates%20in%20gastric%20cancer&rft.jtitle=Cancer%20biomarkers%20:%20section%20A%20of%20Disease%20markers&rft.au=Liu,%20Baohong&rft.date=2022-01-01&rft.volume=34&rft.issue=2&rft.spage=251&rft.epage=264&rft.pages=251-264&rft.issn=1574-0153&rft.eissn=1875-8592&rft_id=info:doi/10.3233/CBM-210335&rft_dat=%3Cproquest_AFRWT%3E2667821197%3C/proquest_AFRWT%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2667821197&rft_id=info:pmid/34958001&rft_sage_id=10.3233_CBM-210335&rfr_iscdi=true |