PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer

Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor...

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Veröffentlicht in:Cancer biomarkers : section A of Disease markers 2022-01, Vol.34 (2), p.251-264
Hauptverfasser: Liu, Baohong, Xiao, Xingxing, Lin, Ziqin, Lou, Yongliang, Zhao, Lingling
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container_issue 2
container_start_page 251
container_title Cancer biomarkers : section A of Disease markers
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creator Liu, Baohong
Xiao, Xingxing
Lin, Ziqin
Lou, Yongliang
Zhao, Lingling
description Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.
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Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</description><identifier>ISSN: 1574-0153</identifier><identifier>EISSN: 1875-8592</identifier><identifier>DOI: 10.3233/CBM-210335</identifier><identifier>PMID: 34958001</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Algorithms ; Angiogenesis ; Biomarkers ; Cancer ; Cell proliferation ; Gastric cancer ; Growth factors ; Immune system ; Infiltration ; Macrophages ; Metastases ; Microenvironments ; Morbidity ; Platelet-derived growth factor ; Platelet-derived growth factor receptors ; Prognosis ; Tumors</subject><ispartof>Cancer biomarkers : section A of Disease markers, 2022-01, Vol.34 (2), p.251-264</ispartof><rights>2022 – IOS Press. 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Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</description><subject>Algorithms</subject><subject>Angiogenesis</subject><subject>Biomarkers</subject><subject>Cancer</subject><subject>Cell proliferation</subject><subject>Gastric cancer</subject><subject>Growth factors</subject><subject>Immune system</subject><subject>Infiltration</subject><subject>Macrophages</subject><subject>Metastases</subject><subject>Microenvironments</subject><subject>Morbidity</subject><subject>Platelet-derived growth factor</subject><subject>Platelet-derived growth factor receptors</subject><subject>Prognosis</subject><subject>Tumors</subject><issn>1574-0153</issn><issn>1875-8592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNptkMlKBDEQhoMo7hcfQAIeFKE1ayd9dMYVFEX03GTS1WO0lzFJI769GWZUEE8pwld_VX0I7VFywhnnp-PRXcYo4VyuoE2qlcy0LNhqqqUSGaGSb6CtEF4JEZyyYh1tcFFITQjdRPbh_OrycYRdwAbP-ghddKbBM99Puz5EZ_HE9a3xb-Cx6Spse--hMREq_OHiC3ZtO3SAXVe7Jvr0H1KNpyZEn3qt6Sz4HbRWmybA7vLdRs-XF0_j6-z2_upmfHabWaZUzHiuhJCVKSjNgQouajkRRrN0IrdG5KaqagW8ZlrUhdZc12DshJCqEhoEoXwbHS1y0_bvA4RYti5YaBrTQT-EkuVUKMkLphJ68Ad97Qffpe0SlSvNKC3m1PGCsr4PwUNdzrxLMj5LSsq5-jKpLxfqE7y_jBwmLVQ_6LfrBBwugGCm8Dvvn6gv3UaJhw</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Liu, Baohong</creator><creator>Xiao, Xingxing</creator><creator>Lin, Ziqin</creator><creator>Lou, Yongliang</creator><creator>Zhao, Lingling</creator><general>SAGE Publications</general><general>IOS Press BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220101</creationdate><title>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</title><author>Liu, Baohong ; Xiao, Xingxing ; Lin, Ziqin ; Lou, Yongliang ; Zhao, Lingling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-367445da9116e1434f5b4a822333ca46addf7e3f284f98838feacb00dd48e4013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Algorithms</topic><topic>Angiogenesis</topic><topic>Biomarkers</topic><topic>Cancer</topic><topic>Cell proliferation</topic><topic>Gastric cancer</topic><topic>Growth factors</topic><topic>Immune system</topic><topic>Infiltration</topic><topic>Macrophages</topic><topic>Metastases</topic><topic>Microenvironments</topic><topic>Morbidity</topic><topic>Platelet-derived growth factor</topic><topic>Platelet-derived growth factor receptors</topic><topic>Prognosis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Baohong</creatorcontrib><creatorcontrib>Xiao, Xingxing</creatorcontrib><creatorcontrib>Lin, Ziqin</creatorcontrib><creatorcontrib>Lou, Yongliang</creatorcontrib><creatorcontrib>Zhao, Lingling</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer biomarkers : section A of Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Baohong</au><au>Xiao, Xingxing</au><au>Lin, Ziqin</au><au>Lou, Yongliang</au><au>Zhao, Lingling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer</atitle><jtitle>Cancer biomarkers : section A of Disease markers</jtitle><addtitle>Cancer Biomark</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>34</volume><issue>2</issue><spage>251</spage><epage>264</epage><pages>251-264</pages><issn>1574-0153</issn><eissn>1875-8592</eissn><abstract>Gastric cancer (GC) is a common cancer with high mortality and morbidity rates worldwide. Although medical and surgical treatments have improved, the mechanisms of the progression of GC remain unclear. Platelet-derived growth factor receptor- β (PDGFRB) plays a pivotal role in angiogenesis and tumor cell proliferation and has been suggested as a prognostic marker of cancer. This study aimed to explore the relationship of PDGFRB expression with clinicopathologic characteristics, immune cell infiltration status, and prognosis in GC. In this study, we visualized the expression and prognostic values of PDGFRB in GC using the Oncomine, UALCAN, GEPIA, and Kaplan-Meier Plotter databases. And then we explored the potential relationships between PDGFRB expression and the levels of immune cell infiltration using the TIMER, GEPIA databases and CIBERSORT algorithm. Furthermore, LinkedOmics analysis was performed to explore the functions for PDGFRB. The results showed close correlations between PDGFRB and immune cell infiltration especially M2 Macrophage infiltration in GC. High PDGFRB expression was related to poor outcomes in GC. High PDGFRB expression can negatively affect GC prognosis by promoting angiogenesis and modulating the tumor immune microenvironment. These results strongly suggest that PDGFRB can be used as a prognostic biomarker of GC and provide novel insights into possible immunotherapeutic targets.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>34958001</pmid><doi>10.3233/CBM-210335</doi><tpages>14</tpages></addata></record>
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source Sage Journals GOLD Open Access 2024
subjects Algorithms
Angiogenesis
Biomarkers
Cancer
Cell proliferation
Gastric cancer
Growth factors
Immune system
Infiltration
Macrophages
Metastases
Microenvironments
Morbidity
Platelet-derived growth factor
Platelet-derived growth factor receptors
Prognosis
Tumors
title PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
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