The impact of prehistoric human dispersals on the presence of tobacco-related oral cancer in Northeast India

•An updated prehistoric AMH dispersal route in and out of NE India has been unveiled.•TrOC-linked autosomal loci & mtDNA-based marker predicted feasible migration route.•Prehistoric AMH dispersal probably linked with the high TrOC prevalence in NE India.•Back-migration from SE Asia (∼4kya) most...

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Veröffentlicht in:	Gene 2022-03, Vol.813, p.146098-146098, Article 146098
Hauptverfasser:	Kundu, Sharbadeb, Dhar, Bishal, Das, Raima, Laskar, Shaheen, Singh, Seram Anil, Kapfo, Wetetsho, Paul, Rajesh, Ramshankar, Vijayalakshmi, Choudhury, Yashmin, Ghosh, Sankar Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AMOVA Anatomically modern human dispersal Ancestry-specific allele frequency Asians - genetics Case-Control Studies Disease-associated admixture component DNA, Mitochondrial - genetics Ethnicity - genetics Female Gene Frequency Genetic Predisposition to Disease Genetic Variation Genetics, Population - methods Global admixture analysis Haplotypes Human Migration Humans India - epidemiology Male Middle Aged Migration analysis Mitochondrial macro-haplogroup diversity Mouth Neoplasms - blood Mouth Neoplasms - epidemiology Mouth Neoplasms - etiology Mouth Neoplasms - genetics mtDNA-based marker Multidimensional scaling Northeast India Oral cancer susceptibility autosomal loci Phylogeny Prehistoric migration route Prolonged tobacco-chewers Tobacco Smoking Tobacco Use - blood Tobacco Use - epidemiology Tobacco Use - genetics Tobacco-related oral cancer Young Adult
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