Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo

Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent invest...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2022-01, Vol.915, p.174610, Article 174610
Hauptverfasser:	Cao, Pan, Chen, Qian, Shi, Chunxia, Pei, Maohua, Wang, Luwen, Gong, Zuojiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute liver failure Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Apoptosis - drug effects Flavanones - pharmacology Flavanones - therapeutic use Hepatocytes - drug effects Hepatocytes - metabolism Inflammatory reaction Lipopolysaccharides - pharmacology Liver Failure, Acute - chemically induced Liver Failure, Acute - drug therapy Liver Failure, Acute - metabolism Macrophage infiltration Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Pinocembrin PPAR alpha - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects Sirt1 Sirtuin 1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!