Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo
Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent invest...
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| Veröffentlicht in: | European journal of pharmacology 2022-01, Vol.915, p.174610, Article 174610 |
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| creator | Cao, Pan Chen, Qian Shi, Chunxia Pei, Maohua Wang, Luwen Gong, Zuojiong |
| description | Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent investigations demonstrate that Pinocembrin has a variety of pharmacological activities, including anti-inflammatory and antioxidant. To investigate the effects of Pinocembrin on ALF, we explored its possible molecular mechanisms through the experiments in vivo and in vitro. Pre-treatment with Pinocembrin attenuated LPS-induced hepatocyte dysfunction and reduced levels of pro-inflammatory factors and macrophages infiltration. Pinocembrin inhibited the hepatocyte apoptosis and pro-inflammatory reaction of peritoneal macrophages by reducing reactive oxygen species (ROS) via the Sirt1/PPARα signaling pathway. Our study suggests that Pinocembrin might represent a novel therapeutic drug and offers a new method for the treatment of ALF.
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| doi_str_mv | 10.1016/j.ejphar.2021.174610 |
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[Display omitted]</description><identifier>ISSN: 0014-2999</identifier><identifier>ISSN: 1879-0712</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2021.174610</identifier><identifier>PMID: 34951978</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute liver failure ; Animals ; Anti-Inflammatory Agents - pharmacology ; Anti-Inflammatory Agents - therapeutic use ; Apoptosis - drug effects ; Flavanones - pharmacology ; Flavanones - therapeutic use ; Hepatocytes - drug effects ; Hepatocytes - metabolism ; Inflammatory reaction ; Lipopolysaccharides - pharmacology ; Liver Failure, Acute - chemically induced ; Liver Failure, Acute - drug therapy ; Liver Failure, Acute - metabolism ; Macrophage infiltration ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Pinocembrin ; PPAR alpha - metabolism ; Reactive Oxygen Species - metabolism ; Signal Transduction - drug effects ; Sirt1 ; Sirtuin 1 - metabolism</subject><ispartof>European journal of pharmacology, 2022-01, Vol.915, p.174610, Article 174610</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-f9159ccc0b64f6f138a6acc129961c0eea04db860b06bd0fe7447ae44f12d0f73</citedby><cites>FETCH-LOGICAL-c362t-f9159ccc0b64f6f138a6acc129961c0eea04db860b06bd0fe7447ae44f12d0f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299921007664$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34951978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Pan</creatorcontrib><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Shi, Chunxia</creatorcontrib><creatorcontrib>Pei, Maohua</creatorcontrib><creatorcontrib>Wang, Luwen</creatorcontrib><creatorcontrib>Gong, Zuojiong</creatorcontrib><title>Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent investigations demonstrate that Pinocembrin has a variety of pharmacological activities, including anti-inflammatory and antioxidant. To investigate the effects of Pinocembrin on ALF, we explored its possible molecular mechanisms through the experiments in vivo and in vitro. Pre-treatment with Pinocembrin attenuated LPS-induced hepatocyte dysfunction and reduced levels of pro-inflammatory factors and macrophages infiltration. Pinocembrin inhibited the hepatocyte apoptosis and pro-inflammatory reaction of peritoneal macrophages by reducing reactive oxygen species (ROS) via the Sirt1/PPARα signaling pathway. Our study suggests that Pinocembrin might represent a novel therapeutic drug and offers a new method for the treatment of ALF.
[Display omitted]</description><subject>Acute liver failure</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Apoptosis - drug effects</subject><subject>Flavanones - pharmacology</subject><subject>Flavanones - therapeutic use</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - metabolism</subject><subject>Inflammatory reaction</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Liver Failure, Acute - chemically induced</subject><subject>Liver Failure, Acute - drug therapy</subject><subject>Liver Failure, Acute - metabolism</subject><subject>Macrophage infiltration</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pinocembrin</subject><subject>PPAR alpha - metabolism</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Sirt1</subject><subject>Sirtuin 1 - metabolism</subject><issn>0014-2999</issn><issn>1879-0712</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1O3DAQhS1UVLa0b1BVvuxNlhnH68Q3SAj1T0JiRdtry3EmrFf5WWwnFY_Fi_BMDQpwydXojM6Z0fkY-4ywRkB1tl_T_rCzYS1A4BoLqRCO2ArLQmdQoHjHVgAoM6G1PmEfYtwDwEaLzXt2kku9QV2UK7bb-n5w1FXB99x21Poh2ESRWzcm4q2fKPDG-nYMxCdv533yk02-v-VpR_y3DwnPttuLm8cHfrBp98_e8_nU5FMYuO3rRUzDR3bc2DbSp-d5yv5-__bn8md2df3j1-XFVeZyJVLWaNxo5xxUSjaqwby0yjqHcwuFDogsyLoqFVSgqhoaKqQsLEnZoJhlkZ-yr8vdQxjuRorJdD46alvb0zBGIxRKkeuyxNkqF6sLQ4yBGnMIvrPh3iCYJ8ZmbxbG5omxWRjPsS_PH8aqo_o19AJ1NpwvBpp7Tp6Cic5T76j2gVwy9eDf_vAfckaQtQ</recordid><startdate>20220115</startdate><enddate>20220115</enddate><creator>Cao, Pan</creator><creator>Chen, Qian</creator><creator>Shi, Chunxia</creator><creator>Pei, Maohua</creator><creator>Wang, Luwen</creator><creator>Gong, Zuojiong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220115</creationdate><title>Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo</title><author>Cao, Pan ; Chen, Qian ; Shi, Chunxia ; Pei, Maohua ; Wang, Luwen ; Gong, Zuojiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-f9159ccc0b64f6f138a6acc129961c0eea04db860b06bd0fe7447ae44f12d0f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute liver failure</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Apoptosis - drug effects</topic><topic>Flavanones - pharmacology</topic><topic>Flavanones - therapeutic use</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - metabolism</topic><topic>Inflammatory reaction</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Liver Failure, Acute - chemically induced</topic><topic>Liver Failure, Acute - drug therapy</topic><topic>Liver Failure, Acute - metabolism</topic><topic>Macrophage infiltration</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pinocembrin</topic><topic>PPAR alpha - metabolism</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>Sirt1</topic><topic>Sirtuin 1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Pan</creatorcontrib><creatorcontrib>Chen, Qian</creatorcontrib><creatorcontrib>Shi, Chunxia</creatorcontrib><creatorcontrib>Pei, Maohua</creatorcontrib><creatorcontrib>Wang, Luwen</creatorcontrib><creatorcontrib>Gong, Zuojiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Pan</au><au>Chen, Qian</au><au>Shi, Chunxia</au><au>Pei, Maohua</au><au>Wang, Luwen</au><au>Gong, Zuojiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2022-01-15</date><risdate>2022</risdate><volume>915</volume><spage>174610</spage><pages>174610-</pages><artnum>174610</artnum><issn>0014-2999</issn><issn>1879-0712</issn><eissn>1879-0712</eissn><abstract>Acute liver failure (ALF) is a life-threatening disease and affects multiple organ systems. Pro-inflammatory factors derived from macrophage plays a key role in septicemia. Pinocembrin is a natural favonoid compound, which can be extracted from honey, propolis and several other plants. Recent investigations demonstrate that Pinocembrin has a variety of pharmacological activities, including anti-inflammatory and antioxidant. To investigate the effects of Pinocembrin on ALF, we explored its possible molecular mechanisms through the experiments in vivo and in vitro. Pre-treatment with Pinocembrin attenuated LPS-induced hepatocyte dysfunction and reduced levels of pro-inflammatory factors and macrophages infiltration. Pinocembrin inhibited the hepatocyte apoptosis and pro-inflammatory reaction of peritoneal macrophages by reducing reactive oxygen species (ROS) via the Sirt1/PPARα signaling pathway. Our study suggests that Pinocembrin might represent a novel therapeutic drug and offers a new method for the treatment of ALF.
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| subjects | Acute liver failure Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Apoptosis - drug effects Flavanones - pharmacology Flavanones - therapeutic use Hepatocytes - drug effects Hepatocytes - metabolism Inflammatory reaction Lipopolysaccharides - pharmacology Liver Failure, Acute - chemically induced Liver Failure, Acute - drug therapy Liver Failure, Acute - metabolism Macrophage infiltration Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice Mice, Inbred C57BL Pinocembrin PPAR alpha - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects Sirt1 Sirtuin 1 - metabolism |
| title | Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo |
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