Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs

[Display omitted] •With Temporin-1CEc as a original peptide, 12 analogs are designed and synthesized to research SAR.•2K2L and 2K4L have the potential to combat multidrug-resistant bacterial strains.•2K2L and 2K4L induce membrane depolarization and inhibit biofilm forming of MRSE1208. Antimicrobial...

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Veröffentlicht in:	Bioorganic chemistry 2022-02, Vol.119, p.105544-105544, Article 105544
Hauptverfasser:	Ji, Fangyu, Zhao, Ying, Jiang, Fengquan, Shang, Dejing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antimicrobial peptide Antimicrobial Peptides - chemistry Antimicrobial Peptides - isolation & purification Antimicrobial Peptides - pharmacology Biofilm Dose-Response Relationship, Drug Drug Resistance, Multiple, Bacterial - drug effects Hydrophobic Membrane Microbial Sensitivity Tests Molecular Structure Multiple-drug resistant Ranidae Skin - chemistry Staphylococcus epidermidis - drug effects Structure-Activity Relationship
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