Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness
Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects. Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests wer...
Gespeichert in:
| Veröffentlicht in: | American journal of otolaryngology 2022-03, Vol.43 (2), p.103331-103331, Article 103331 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103331 |
|---|---|
| container_issue | 2 |
| container_start_page | 103331 |
| container_title | American journal of otolaryngology |
| container_volume | 43 |
| creator | Chen, Kaitian Sun, Jincangjian Huang, Bixue Liang, Yue Liu, Min Wu, Xuan |
| description | Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects.
Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests were included. The main outcome measures included clinical characteristics, radiology, and functional test results.
The morphological findings and functional tests revealed differences in locations and lesional spectrums. The magnetic resonance imaging (MRI) hyperintensity was likely to involve the vestibule (88.2%), the cochlea (76.5%), and the posterior and lateral semicircular canals (76.5% and 70.6%, respectively). Furthermore, 70.6% of cases showed abnormality in the entire labyrinth, and abnormalities in the vestibule/semicircular canals were observed in 17.6% of cases. Meanwhile, dysfunction was sequentially detected in the cochlea (100%), semicircular canals (94.1%), and vestibule (70.6%); 64.7% of cases showed combined deficit in the entire labyrinth, and 29.4% of cases showed combined deficit in the cochlea/semicircular canals. Although lesions in the labyrinth were frequently detected, the results of the radiological and functional tests did not always match and significantly differed in either cochlear or superior semicircular canal damage detection (p |
| doi_str_mv | 10.1016/j.amjoto.2021.103331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2614233906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196070921004324</els_id><sourcerecordid>2614233906</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-7adbc0a43e6636921b2b261e555214c7f85f87e586ea33f400a7518a29da7c533</originalsourceid><addsrcrecordid>eNp9kMtKxTAQhoMoery8gUjBjZsec2mSdiOIeIMjbhTchTSdelLa5Ji0gm9vpOrChasMmW_-GT6EjgleEkzEebfUQ-dHv6SYkvTFGCNbaEE4o3lJypdttMCkEjmWuNpD-zF2GGNWML6L9lhRcVoQuUAPK11_BOvGtXWQ9RCtdzGzLtsEiNMATaodhAx0yNYw-BDW-hXyAL0eUzNOTQMua0C3DmI8RDut7iMcfb8H6Pnm-unqLl893t5fXa5ywyo85lI3tcG6YCAEExUlNa2pIMA5p6Qwsi15W0rgpQDNWFtgrCUnpaZVo6XhjB2gszl3E_zbBHFUg40G-l478FNUKaygLO0SCT39g3Z-Ci5dlygmq0pyQRNVzJQJPsYArdoEO-jwoQhWX7pVp2bd6ku3mnWnsZPv8KlOrn6Hfvwm4GIGINl4txBUNBacgcYGMKNqvP1_wyeN1ZGr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2637997562</pqid></control><display><type>article</type><title>Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Chen, Kaitian ; Sun, Jincangjian ; Huang, Bixue ; Liang, Yue ; Liu, Min ; Wu, Xuan</creator><creatorcontrib>Chen, Kaitian ; Sun, Jincangjian ; Huang, Bixue ; Liang, Yue ; Liu, Min ; Wu, Xuan</creatorcontrib><description>Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects.
Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests were included. The main outcome measures included clinical characteristics, radiology, and functional test results.
The morphological findings and functional tests revealed differences in locations and lesional spectrums. The magnetic resonance imaging (MRI) hyperintensity was likely to involve the vestibule (88.2%), the cochlea (76.5%), and the posterior and lateral semicircular canals (76.5% and 70.6%, respectively). Furthermore, 70.6% of cases showed abnormality in the entire labyrinth, and abnormalities in the vestibule/semicircular canals were observed in 17.6% of cases. Meanwhile, dysfunction was sequentially detected in the cochlea (100%), semicircular canals (94.1%), and vestibule (70.6%); 64.7% of cases showed combined deficit in the entire labyrinth, and 29.4% of cases showed combined deficit in the cochlea/semicircular canals. Although lesions in the labyrinth were frequently detected, the results of the radiological and functional tests did not always match and significantly differed in either cochlear or superior semicircular canal damage detection (p < 0.05 each).
In this cohort, IEH preferentially caused sudden audio-vestibular impairment, which was well demonstrated by a combination of MRI and functional tests. The specific lesional configurations revealed in this study may suggest a possible pathomechanism that could be further explored as a therapeutic target.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2021.103331</identifier><identifier>PMID: 34952417</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abnormalities ; Age ; Cochlea ; Damage detection ; Deafness ; Diabetes ; Ear ; Ears & hearing ; Functional magnetic resonance imaging ; Functional testing ; Hearing loss ; Hearing Loss, Sensorineural - diagnosis ; Hearing Loss, Sensorineural - etiology ; Hearing Loss, Sudden - diagnosis ; Hearing Loss, Sudden - etiology ; Hemorrhage ; Hemorrhage - complications ; Humans ; Inner ear ; Inner ear hemorrhage ; Laboratories ; Labyrinth ; Lesions ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Morphology ; Paresis ; Pathophysiology ; Patients ; Radiology ; Semicircular canals ; Semicircular Canals - diagnostic imaging ; Software ; Statistical analysis ; Sudden sensorineural hearing loss ; Therapeutic targets ; Vertigo ; Vestibular disorder ; Vestibular system ; Vestibular tests ; Vestibule, Labyrinth - diagnostic imaging ; Vestibules</subject><ispartof>American journal of otolaryngology, 2022-03, Vol.43 (2), p.103331-103331, Article 103331</ispartof><rights>2021</rights><rights>Copyright © 2021. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Mar 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-7adbc0a43e6636921b2b261e555214c7f85f87e586ea33f400a7518a29da7c533</citedby><cites>FETCH-LOGICAL-c390t-7adbc0a43e6636921b2b261e555214c7f85f87e586ea33f400a7518a29da7c533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjoto.2021.103331$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34952417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Kaitian</creatorcontrib><creatorcontrib>Sun, Jincangjian</creatorcontrib><creatorcontrib>Huang, Bixue</creatorcontrib><creatorcontrib>Liang, Yue</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wu, Xuan</creatorcontrib><title>Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects.
Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests were included. The main outcome measures included clinical characteristics, radiology, and functional test results.
The morphological findings and functional tests revealed differences in locations and lesional spectrums. The magnetic resonance imaging (MRI) hyperintensity was likely to involve the vestibule (88.2%), the cochlea (76.5%), and the posterior and lateral semicircular canals (76.5% and 70.6%, respectively). Furthermore, 70.6% of cases showed abnormality in the entire labyrinth, and abnormalities in the vestibule/semicircular canals were observed in 17.6% of cases. Meanwhile, dysfunction was sequentially detected in the cochlea (100%), semicircular canals (94.1%), and vestibule (70.6%); 64.7% of cases showed combined deficit in the entire labyrinth, and 29.4% of cases showed combined deficit in the cochlea/semicircular canals. Although lesions in the labyrinth were frequently detected, the results of the radiological and functional tests did not always match and significantly differed in either cochlear or superior semicircular canal damage detection (p < 0.05 each).
In this cohort, IEH preferentially caused sudden audio-vestibular impairment, which was well demonstrated by a combination of MRI and functional tests. The specific lesional configurations revealed in this study may suggest a possible pathomechanism that could be further explored as a therapeutic target.</description><subject>Abnormalities</subject><subject>Age</subject><subject>Cochlea</subject><subject>Damage detection</subject><subject>Deafness</subject><subject>Diabetes</subject><subject>Ear</subject><subject>Ears & hearing</subject><subject>Functional magnetic resonance imaging</subject><subject>Functional testing</subject><subject>Hearing loss</subject><subject>Hearing Loss, Sensorineural - diagnosis</subject><subject>Hearing Loss, Sensorineural - etiology</subject><subject>Hearing Loss, Sudden - diagnosis</subject><subject>Hearing Loss, Sudden - etiology</subject><subject>Hemorrhage</subject><subject>Hemorrhage - complications</subject><subject>Humans</subject><subject>Inner ear</subject><subject>Inner ear hemorrhage</subject><subject>Laboratories</subject><subject>Labyrinth</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Morphology</subject><subject>Paresis</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Radiology</subject><subject>Semicircular canals</subject><subject>Semicircular Canals - diagnostic imaging</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Sudden sensorineural hearing loss</subject><subject>Therapeutic targets</subject><subject>Vertigo</subject><subject>Vestibular disorder</subject><subject>Vestibular system</subject><subject>Vestibular tests</subject><subject>Vestibule, Labyrinth - diagnostic imaging</subject><subject>Vestibules</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxTAQhoMoery8gUjBjZsec2mSdiOIeIMjbhTchTSdelLa5Ji0gm9vpOrChasMmW_-GT6EjgleEkzEebfUQ-dHv6SYkvTFGCNbaEE4o3lJypdttMCkEjmWuNpD-zF2GGNWML6L9lhRcVoQuUAPK11_BOvGtXWQ9RCtdzGzLtsEiNMATaodhAx0yNYw-BDW-hXyAL0eUzNOTQMua0C3DmI8RDut7iMcfb8H6Pnm-unqLl893t5fXa5ywyo85lI3tcG6YCAEExUlNa2pIMA5p6Qwsi15W0rgpQDNWFtgrCUnpaZVo6XhjB2gszl3E_zbBHFUg40G-l478FNUKaygLO0SCT39g3Z-Ci5dlygmq0pyQRNVzJQJPsYArdoEO-jwoQhWX7pVp2bd6ku3mnWnsZPv8KlOrn6Hfvwm4GIGINl4txBUNBacgcYGMKNqvP1_wyeN1ZGr</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Chen, Kaitian</creator><creator>Sun, Jincangjian</creator><creator>Huang, Bixue</creator><creator>Liang, Yue</creator><creator>Liu, Min</creator><creator>Wu, Xuan</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202203</creationdate><title>Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness</title><author>Chen, Kaitian ; Sun, Jincangjian ; Huang, Bixue ; Liang, Yue ; Liu, Min ; Wu, Xuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-7adbc0a43e6636921b2b261e555214c7f85f87e586ea33f400a7518a29da7c533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abnormalities</topic><topic>Age</topic><topic>Cochlea</topic><topic>Damage detection</topic><topic>Deafness</topic><topic>Diabetes</topic><topic>Ear</topic><topic>Ears & hearing</topic><topic>Functional magnetic resonance imaging</topic><topic>Functional testing</topic><topic>Hearing loss</topic><topic>Hearing Loss, Sensorineural - diagnosis</topic><topic>Hearing Loss, Sensorineural - etiology</topic><topic>Hearing Loss, Sudden - diagnosis</topic><topic>Hearing Loss, Sudden - etiology</topic><topic>Hemorrhage</topic><topic>Hemorrhage - complications</topic><topic>Humans</topic><topic>Inner ear</topic><topic>Inner ear hemorrhage</topic><topic>Laboratories</topic><topic>Labyrinth</topic><topic>Lesions</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Morphology</topic><topic>Paresis</topic><topic>Pathophysiology</topic><topic>Patients</topic><topic>Radiology</topic><topic>Semicircular canals</topic><topic>Semicircular Canals - diagnostic imaging</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Sudden sensorineural hearing loss</topic><topic>Therapeutic targets</topic><topic>Vertigo</topic><topic>Vestibular disorder</topic><topic>Vestibular system</topic><topic>Vestibular tests</topic><topic>Vestibule, Labyrinth - diagnostic imaging</topic><topic>Vestibules</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Kaitian</creatorcontrib><creatorcontrib>Sun, Jincangjian</creatorcontrib><creatorcontrib>Huang, Bixue</creatorcontrib><creatorcontrib>Liang, Yue</creatorcontrib><creatorcontrib>Liu, Min</creatorcontrib><creatorcontrib>Wu, Xuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Kaitian</au><au>Sun, Jincangjian</au><au>Huang, Bixue</au><au>Liang, Yue</au><au>Liu, Min</au><au>Wu, Xuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2022-03</date><risdate>2022</risdate><volume>43</volume><issue>2</issue><spage>103331</spage><epage>103331</epage><pages>103331-103331</pages><artnum>103331</artnum><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract>Inner ear hemorrhage (IEH) is a rare cause of sudden sensorineural hearing loss (SSNHL). This study aimed to evaluate the lesional patterns in patients with presumed IEH from morphological and functional aspects.
Seventeen patients with SSNHL and presumed IEH who completed audio-vestibular tests were included. The main outcome measures included clinical characteristics, radiology, and functional test results.
The morphological findings and functional tests revealed differences in locations and lesional spectrums. The magnetic resonance imaging (MRI) hyperintensity was likely to involve the vestibule (88.2%), the cochlea (76.5%), and the posterior and lateral semicircular canals (76.5% and 70.6%, respectively). Furthermore, 70.6% of cases showed abnormality in the entire labyrinth, and abnormalities in the vestibule/semicircular canals were observed in 17.6% of cases. Meanwhile, dysfunction was sequentially detected in the cochlea (100%), semicircular canals (94.1%), and vestibule (70.6%); 64.7% of cases showed combined deficit in the entire labyrinth, and 29.4% of cases showed combined deficit in the cochlea/semicircular canals. Although lesions in the labyrinth were frequently detected, the results of the radiological and functional tests did not always match and significantly differed in either cochlear or superior semicircular canal damage detection (p < 0.05 each).
In this cohort, IEH preferentially caused sudden audio-vestibular impairment, which was well demonstrated by a combination of MRI and functional tests. The specific lesional configurations revealed in this study may suggest a possible pathomechanism that could be further explored as a therapeutic target.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34952417</pmid><doi>10.1016/j.amjoto.2021.103331</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-0709 |
| ispartof | American journal of otolaryngology, 2022-03, Vol.43 (2), p.103331-103331, Article 103331 |
| issn | 0196-0709 1532-818X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2614233906 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Abnormalities Age Cochlea Damage detection Deafness Diabetes Ear Ears & hearing Functional magnetic resonance imaging Functional testing Hearing loss Hearing Loss, Sensorineural - diagnosis Hearing Loss, Sensorineural - etiology Hearing Loss, Sudden - diagnosis Hearing Loss, Sudden - etiology Hemorrhage Hemorrhage - complications Humans Inner ear Inner ear hemorrhage Laboratories Labyrinth Lesions Magnetic resonance imaging Magnetic Resonance Imaging - methods Morphology Paresis Pathophysiology Patients Radiology Semicircular canals Semicircular Canals - diagnostic imaging Software Statistical analysis Sudden sensorineural hearing loss Therapeutic targets Vertigo Vestibular disorder Vestibular system Vestibular tests Vestibule, Labyrinth - diagnostic imaging Vestibules |
| title | Labyrinthine lesions in presumed inner ear hemorrhage-related sudden deafness |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T10%3A53%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Labyrinthine%20lesions%20in%20presumed%20inner%20ear%20hemorrhage-related%20sudden%20deafness&rft.jtitle=American%20journal%20of%20otolaryngology&rft.au=Chen,%20Kaitian&rft.date=2022-03&rft.volume=43&rft.issue=2&rft.spage=103331&rft.epage=103331&rft.pages=103331-103331&rft.artnum=103331&rft.issn=0196-0709&rft.eissn=1532-818X&rft_id=info:doi/10.1016/j.amjoto.2021.103331&rft_dat=%3Cproquest_cross%3E2614233906%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2637997562&rft_id=info:pmid/34952417&rft_els_id=S0196070921004324&rfr_iscdi=true |