Small molecule targeting of chromatin writers in cancer

More than a decade after the launch of DNA methyltransferase and histone deacetylase inhibitors for the treatment of cancer, 2020 heralded the approval of the first histone methyltransferase inhibitor, revitalizing the concept that targeted manipulation of the chromatin regulatory landscape can have...

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Veröffentlicht in:	Nature chemical biology 2022-02, Vol.18 (2), p.124-133
Hauptverfasser:	Conery, Andrew R., Rocnik, Jennifer L., Trojer, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/458 631/92/613 692/699/67/1059 Acetylation Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Cancer Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Chromatin Chromatin - metabolism Deoxyribonucleic acid DNA DNA methylation DNA methyltransferase DNA probes Drug Delivery Systems Drug development Enzymes Epigenetics Gene Expression Regulation, Neoplastic - drug effects Genetics Histone deacetylase Histone methyltransferase Histones Humans Neoplasms - genetics Neoplasms - metabolism Probes Review Article Writers
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