PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP‐HSP70‐BAG3 complex and the aggregation of ubiquitinated proteins

Protein aggregation and degradation via autophagy (aggrephagy) are major strategies adopted by cells to remove misfolded polypeptides when there is proteasome dysfunction. The functional protein complex consisting of heat shock protein 70 (Hsp70), cochaperone ubiquitin ligase carboxyl‐terminal of Hs...

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