HuR-targeted agents: An insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models

[Display omitted] •Chemical features of HuR modulators.•HuR structural features and interactions with HuR modulators.•HuR modulators target the hallmarks of cancer.•HuR modulators target inflammatory process. The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously expressed in huma...

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Veröffentlicht in:	Advanced drug delivery reviews 2022-02, Vol.181, p.114088-114088, Article 114088
Hauptverfasser:	Assoni, Giulia, La Pietra, Valeria, Digilio, Rosangela, Ciani, Caterina, Licata, Nausicaa Valentina, Micaelli, Mariachiara, Facen, Elisa, Tomaszewska, Weronika, Cerofolini, Linda, Pérez-Ràfols, Anna, Varela Rey, Marta, Fragai, Marco, Woodhoo, Ashwin, Marinelli, Luciana, Arosio, Daniela, Bonomo, Isabelle, Provenzani, Alessandro, Seneci, Pierfausto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical features of HuR modulators Drug Delivery Systems - methods ELAV-Like Protein 1 - antagonists & inhibitors ELAV-Like Protein 1 - metabolism Gene Silencing Hallmarks of cancer Humans HuR modulators HuR role in immunity Inflammation Mediators - metabolism Molecular Weight Neoplasms - drug therapy Neoplasms - physiopathology RNA - metabolism RNA - pharmacology RNA, Messenger - pharmacology RNA, Small Interfering - pharmacology Structural interactions of HuR modulators
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