Quercetin attenuates the cardiotoxicity of doxorubicin–cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple‐negative breast cancer

Doxorubicin combined with cyclophosphamide (AC) is the most commonly used regimen for triple‐negative breast cancer (TNBC) chemotherapy; however, its clinical application is severely limited by its serious adverse effect on cardiomyocytes. The cardiotoxicity of AC is mainly the result of oxidative s...

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Veröffentlicht in:	Phytotherapy research 2022-01, Vol.36 (1), p.551-561
Hauptverfasser:	Zhang, Puwei, Zhang, Jianing, Zhao, Lin, Li, Shizheng, Li, Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Anticancer properties Antioxidants Antitumor activity Breast cancer Cardiomyocytes Cardiotoxicity Cardiotoxicity - drug therapy Chemotherapy Cyclophosphamide Cyclophosphamide - adverse effects Doxorubicin Doxorubicin - adverse effects ERK1/2 pathway Humans In vivo methods and tests Injury prevention Oxidative stress Quercetin Quercetin - pharmacology Reactive oxygen species ROS Triple Negative Breast Neoplasms - drug therapy triple‐negative breast cancer
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