SETD8 stabilized by USP17 epigenetically activates SREBP1 pathway to drive lipogenesis and oncogenesis of ccRCC

Recently, epigenetic modifications, including DNA methylation, histone modification and noncoding RNA (ncRNA)-associated gene silencing, have received increasing attention from the scientific community. Many studies have demonstrated that epigenetic regulation can render dynamic alterations in the t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2022-02, Vol.527, p.150-163
Hauptverfasser:	Li, Xiaofeng, Liu, Zhengfang, Xia, Chuanyou, Yan, Keqiang, Fang, Zhiqing, Fan, Yidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biosynthesis Carcinogenesis - genetics Cell cycle Cell growth Cell Line, Tumor Cell Proliferation Clear cell-type renal cell carcinoma DNA methylation Endopeptidases - metabolism Epigenesis, Genetic - genetics Epigenetics Gene expression Gene silencing Histone methyltransferase Histone-Lysine N-Methyltransferase - metabolism Homeostasis Humans Kidney cancer Lipids Lipogenesis Lipogenesis - genetics Lysine Metabolism Metastases Metastasis Mice Plasmids Prognosis Proteins RNA modification RNA-mediated interference Signal Transduction siRNA Sterol regulatory element-binding protein Therapeutic targets Transfection Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!