Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases

•The selective MET inhibitor tepotinib penetrated the intact rat blood–brain barrier.•Tepotinib activity was tested in NSCLC brain metastasis patient-derived xenografts.•Of 20 screened subcutaneous models, two were sensitive to tepotinib.•Both sensitive models had high-level MET amplification (copy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2022-01, Vol.163, p.77-86
Hauptverfasser:	Friese-Hamim, Manja, Clark, Anderson, Perrin, Dominique, Crowley, Lindsey, Reusch, Christof, Bogatyrova, Olga, Zhang, Hong, Crandall, Timothy, Lin, Jing, Ma, Jianguo, Bachner, David, Schmidt, Jürgen, Schaefer, Martin, Stroh, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - diagnostic imaging Brain metastasis Brain Neoplasms - drug therapy Carcinoma, Non-Small-Cell Lung - drug therapy Heterografts Humans Lung Neoplasms - drug therapy MET amplification Non-small cell lung cancer Orthotopic implantation Patient-derived xenograft Piperidines Proto-Oncogene Proteins c-met - metabolism Pyridazines Pyrimidines Rats Rats, Wistar Tepotinib Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!