Differential translational regulation of host exosomal proteins play key role in immunomodulation in antimony resistance in Visceral Leishmaniasis: A proteomic profiling study

In host-pathogen interactions, exosomal secretions are crucial for cell to cell communication and have an established role in immunomodulation. Protozoans, including Leishmania, modulates their host vesicular secretions for better survival; although the role of exosomal secretions in unresponsive ag...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta tropica 2022-02, Vol.226, p.106268-106268, Article 106268
Hauptverfasser:	Abhishek, Kumar, Kumar, Ajay, Sardar, Abul Hasan, Vijayakumar, Saravanan, Dikhit, Manas Ranjan, Kumar, Ashish, Kumar, Vinod, Das, Sushmita, Das, Pradeep
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimony - therapeutic use Antimony resistance Antimony Sodium Gluconate - therapeutic use Antiprotozoal Agents - pharmacology Drug Resistance Exosomes Humans Immune modulatory proteins Immunomodulation LC-MS/MS Leishmania donovani Leishmaniasis, Visceral - drug therapy Proteomics Raw macrophages
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In host-pathogen interactions, exosomal secretions are crucial for cell to cell communication and have an established role in immunomodulation. Protozoans, including Leishmania, modulates their host vesicular secretions for better survival; although the role of exosomal secretions in unresponsive against sodium antimony gluconate (SAG) has never been documented. In this study, the exosomal proteome of RAW macrophages infected with either SAG responsive (SAGS) or SAG unresponsive (SAGR) L. donovani parasites has been compared with uninfected RAW macrophages. Proteins isolated from exosomes were labelled with iTRAQ reagents; followed by subsequent LC-TOF/-MS analysis. In total, 394 proteins (p
ISSN:	0001-706X 1873-6254
DOI:	10.1016/j.actatropica.2021.106268