Old dog, new tricks: Polydatin as a multitarget agent for current diseases
Polydatin (PD) is a natural single‐crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc. Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehens...
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| Veröffentlicht in: | Phytotherapy research 2022-01, Vol.36 (1), p.214-230 |
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| container_title | Phytotherapy research |
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| creator | Ye, Penghui Wu, Hefei Jiang, Yinxiao Xiao, Xiaolin Song, Dan Xu, Nuo Ma, Xiao Zeng, Jinhao Guo, Yaoguang |
| description | Polydatin (PD) is a natural single‐crystal product that is primarily extracted from the traditional plant Polygonum cuspidatum Sieb. et Zucc. Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. In summary, we found that PD played a therapeutic role in a variety of diseases, primarily via five mechanisms: antioxidative effects, antiinflammatory effects, regulation of autophagy and apoptosis, maintenance of mitochondrial function, and lipid regulation. |
| doi_str_mv | 10.1002/ptr.7306 |
| format | Article |
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Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. 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Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. 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Early research showed that PD exhibited a variety of biological activities. PD has attracted increasing research interest since 2014, but no review comprehensively summarized the new findings. A great gap between its biological activities and drug development remains. It is necessary to summarize new findings on the pharmacological effects of PD on current diseases. We propose that PD will most likely be used in cardiac and cerebral ischaemia/reperfusion‐related diseases and atherosclerosis in the future. The present work classified these new findings according to diseases and summarized the main effects of PD via specific mechanisms of action. 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| subjects | antiinflammatory effects antioxidative effects Apoptosis Aquatic plants Arteriosclerosis Atherosclerosis Autophagy Diseases Drug development Drugs, Chinese Herbal - pharmacology Glucosides - pharmacology Ischemia lipid regulation Lipids maintenance of mitochondrial function Mitochondria Plant extracts polydatin regulation of autophagy and apoptosis Reperfusion Stilbenes - pharmacology |
| title | Old dog, new tricks: Polydatin as a multitarget agent for current diseases |
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