Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes
Accumulating evidence suggested that suppression of Propionibacterium acnes- induced inflammation was a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on P. acnes -induced inflammatory acne vulgaris in mice. Epidermis morphology and hi...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2022, Vol.106 (2), p.549-562 |
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| creator | Shan, Mengyuan Meng, Fanqiang Tang, Chao Zhou, Libang Lu, Zhaoxin Lu, Yingjian |
| description | Accumulating evidence suggested that suppression of
Propionibacterium acnes-
induced inflammation was a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on
P. acnes
-induced inflammatory acne vulgaris in mice. Epidermis morphology and histopathological examination showed that surfactin-oleogel effectively ameliorated the
P. acnes
-induced epidermis swelling and erythema. Surfactin-oleogel reduced the epidermis thickness to 48.52% compared to the model control group. The colony of
P. acnes
in the epidermis was decreased by 1 log CFU/mL after receiving surfactin-oleogel treatment. Furthermore, surfactin-oleogel attenuated oxidative stress in the epidermis by increasing the activities of superoxide dismutase, catalase, and glutathione peroxidase. In addition, the expression of inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2, pro-inflammatory cytokines (e.g. tumour necrosis factor-α and interleukin-1β), and nuclear factor kappa-B in the epidermis were reduced after treating with surfactin-oleogel. Moreover, total cholesterol and free fatty acids were decreased, whereas the treatment of surfactin-oleogel increased triglycerides and linoleic acid content. Besides, immunohistochemical assay and real-time PCR analysis indicated that surfactin-oleogel blocked the TLR2-mediated NF-κB signalling pathways in the epidermis. Consequently, our results demonstrated that surfactin-oleogel had antibacterial and anti-inflammation activities to treat
P. acnes
-induced inflammatory acne vulgaris.
Key points
•
Surfactin-oleogel effectively relieves inflammation and oxidative stress caused by P. acnes.
•
Surfactin-oleogel effectively reduced the P. acnes colony.
•
Surfactin-oleogel relieves P. acnes-induced inflammation by inactivated the TLR-mediated NF-κB. |
| doi_str_mv | 10.1007/s00253-021-11719-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2613292627</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A689823100</galeid><sourcerecordid>A689823100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-f8f0b8dab2876186bf40b1b43597f62ddd6de86f230240827ea7ec259fcf1f333</originalsourceid><addsrcrecordid>eNp9kltrFTEUhYMo9lj9Az7IgC_6MDWXmSTzWIqXQkGx-hwymZ1pykxyzEU9_960p1qOiOQhkP2txd47C6HnBJ8QjMWbhDHtWYspaQkRZGjlA7QhHaMt5qR7iDaYiL4V_SCP0JOUrjEmVHL-GB2xbmADYWKD_GWJVpvsfBsWCDMszQ-Xr5p8BVFvoWRnmm3I4LPTS2NDbJy3i15XnUPcNdp4aL6XZdbRpVqaioGpGXfNpxi2Lng3Vm-Irqy3aHqKHlm9JHh2dx-jr-_efjn70F58fH9-dnrRmk7w3Fpp8SgnPVIpOJF8tB0eydixfhCW02ma-ASSW8ow7bCkArQAQ_vBGkssY-wYvdr7bmP4ViBltbpkYFm0h1CSopwwOlBORUVf_oVehxJ97a5SFEvGWUfuqVkvoOoOQo7a3JiqUy4HSVn9kkqd_IOqZ4LVmeDBuvp-IHh9IKhMhp951iUldX75-ZCle9bEkFIEq7bRrTruFMHqJhBqHwhVA6FuA6FkFb24m66MK0x_JL8TUAG2B1It-Rni_fj_sf0FkBS_6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2620836341</pqid></control><display><type>article</type><title>Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>Shan, Mengyuan ; Meng, Fanqiang ; Tang, Chao ; Zhou, Libang ; Lu, Zhaoxin ; Lu, Yingjian</creator><creatorcontrib>Shan, Mengyuan ; Meng, Fanqiang ; Tang, Chao ; Zhou, Libang ; Lu, Zhaoxin ; Lu, Yingjian</creatorcontrib><description>Accumulating evidence suggested that suppression of
Propionibacterium acnes-
induced inflammation was a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on
P. acnes
-induced inflammatory acne vulgaris in mice. Epidermis morphology and histopathological examination showed that surfactin-oleogel effectively ameliorated the
P. acnes
-induced epidermis swelling and erythema. Surfactin-oleogel reduced the epidermis thickness to 48.52% compared to the model control group. The colony of
P. acnes
in the epidermis was decreased by 1 log CFU/mL after receiving surfactin-oleogel treatment. Furthermore, surfactin-oleogel attenuated oxidative stress in the epidermis by increasing the activities of superoxide dismutase, catalase, and glutathione peroxidase. In addition, the expression of inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2, pro-inflammatory cytokines (e.g. tumour necrosis factor-α and interleukin-1β), and nuclear factor kappa-B in the epidermis were reduced after treating with surfactin-oleogel. Moreover, total cholesterol and free fatty acids were decreased, whereas the treatment of surfactin-oleogel increased triglycerides and linoleic acid content. Besides, immunohistochemical assay and real-time PCR analysis indicated that surfactin-oleogel blocked the TLR2-mediated NF-κB signalling pathways in the epidermis. Consequently, our results demonstrated that surfactin-oleogel had antibacterial and anti-inflammation activities to treat
P. acnes
-induced inflammatory acne vulgaris.
Key points
•
Surfactin-oleogel effectively relieves inflammation and oxidative stress caused by P. acnes.
•
Surfactin-oleogel effectively reduced the P. acnes colony.
•
Surfactin-oleogel relieves P. acnes-induced inflammation by inactivated the TLR-mediated NF-κB.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-021-11719-8</identifier><identifier>PMID: 34939137</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acne ; Acne Vulgaris - drug therapy ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Antiacne agents ; Biomedical and Life Sciences ; Biotechnological Products and Process Engineering ; Biotechnology ; Catalase ; Cholesterol ; Colonies ; Cyclooxygenase-2 ; Cytokines ; Epidermis ; Erythema ; Fatty acids ; Glutathione ; Glutathione peroxidase ; IL-1β ; Inflammation ; Interleukins ; Life Sciences ; Linoleic acid ; Mice ; Microbial Genetics and Genomics ; Microbiology ; NF-kappa B ; NF-κB protein ; Nitric oxide ; Nitric-oxide synthase ; Organic Chemicals ; Oxidative stress ; Peroxidase ; Propionibacterium acnes ; Signal transduction ; Superoxide dismutase ; Surface active agents ; Surfactin ; Testing ; TLR2 protein ; Toll-like receptors ; Triglycerides ; Tumor necrosis factor-α ; Tumors</subject><ispartof>Applied microbiology and biotechnology, 2022, Vol.106 (2), p.549-562</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-f8f0b8dab2876186bf40b1b43597f62ddd6de86f230240827ea7ec259fcf1f333</citedby><cites>FETCH-LOGICAL-c476t-f8f0b8dab2876186bf40b1b43597f62ddd6de86f230240827ea7ec259fcf1f333</cites><orcidid>0000-0001-9288-7419</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-021-11719-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-021-11719-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34939137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shan, Mengyuan</creatorcontrib><creatorcontrib>Meng, Fanqiang</creatorcontrib><creatorcontrib>Tang, Chao</creatorcontrib><creatorcontrib>Zhou, Libang</creatorcontrib><creatorcontrib>Lu, Zhaoxin</creatorcontrib><creatorcontrib>Lu, Yingjian</creatorcontrib><title>Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Accumulating evidence suggested that suppression of
Propionibacterium acnes-
induced inflammation was a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on
P. acnes
-induced inflammatory acne vulgaris in mice. Epidermis morphology and histopathological examination showed that surfactin-oleogel effectively ameliorated the
P. acnes
-induced epidermis swelling and erythema. Surfactin-oleogel reduced the epidermis thickness to 48.52% compared to the model control group. The colony of
P. acnes
in the epidermis was decreased by 1 log CFU/mL after receiving surfactin-oleogel treatment. Furthermore, surfactin-oleogel attenuated oxidative stress in the epidermis by increasing the activities of superoxide dismutase, catalase, and glutathione peroxidase. In addition, the expression of inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2, pro-inflammatory cytokines (e.g. tumour necrosis factor-α and interleukin-1β), and nuclear factor kappa-B in the epidermis were reduced after treating with surfactin-oleogel. Moreover, total cholesterol and free fatty acids were decreased, whereas the treatment of surfactin-oleogel increased triglycerides and linoleic acid content. Besides, immunohistochemical assay and real-time PCR analysis indicated that surfactin-oleogel blocked the TLR2-mediated NF-κB signalling pathways in the epidermis. Consequently, our results demonstrated that surfactin-oleogel had antibacterial and anti-inflammation activities to treat
P. acnes
-induced inflammatory acne vulgaris.
Key points
•
Surfactin-oleogel effectively relieves inflammation and oxidative stress caused by P. acnes.
•
Surfactin-oleogel effectively reduced the P. acnes colony.
•
Surfactin-oleogel relieves P. acnes-induced inflammation by inactivated the TLR-mediated NF-κB.</description><subject>Acne</subject><subject>Acne Vulgaris - drug therapy</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Antiacne agents</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnological Products and Process Engineering</subject><subject>Biotechnology</subject><subject>Catalase</subject><subject>Cholesterol</subject><subject>Colonies</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines</subject><subject>Epidermis</subject><subject>Erythema</subject><subject>Fatty acids</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukins</subject><subject>Life Sciences</subject><subject>Linoleic acid</subject><subject>Mice</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>NF-kappa B</subject><subject>NF-κB protein</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Organic Chemicals</subject><subject>Oxidative stress</subject><subject>Peroxidase</subject><subject>Propionibacterium acnes</subject><subject>Signal transduction</subject><subject>Superoxide dismutase</subject><subject>Surface active agents</subject><subject>Surfactin</subject><subject>Testing</subject><subject>TLR2 protein</subject><subject>Toll-like receptors</subject><subject>Triglycerides</subject><subject>Tumor necrosis factor-α</subject><subject>Tumors</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kltrFTEUhYMo9lj9Az7IgC_6MDWXmSTzWIqXQkGx-hwymZ1pykxyzEU9_960p1qOiOQhkP2txd47C6HnBJ8QjMWbhDHtWYspaQkRZGjlA7QhHaMt5qR7iDaYiL4V_SCP0JOUrjEmVHL-GB2xbmADYWKD_GWJVpvsfBsWCDMszQ-Xr5p8BVFvoWRnmm3I4LPTS2NDbJy3i15XnUPcNdp4aL6XZdbRpVqaioGpGXfNpxi2Lng3Vm-Irqy3aHqKHlm9JHh2dx-jr-_efjn70F58fH9-dnrRmk7w3Fpp8SgnPVIpOJF8tB0eydixfhCW02ma-ASSW8ow7bCkArQAQ_vBGkssY-wYvdr7bmP4ViBltbpkYFm0h1CSopwwOlBORUVf_oVehxJ97a5SFEvGWUfuqVkvoOoOQo7a3JiqUy4HSVn9kkqd_IOqZ4LVmeDBuvp-IHh9IKhMhp951iUldX75-ZCle9bEkFIEq7bRrTruFMHqJhBqHwhVA6FuA6FkFb24m66MK0x_JL8TUAG2B1It-Rni_fj_sf0FkBS_6g</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Shan, 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with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes</title><author>Shan, Mengyuan ; Meng, Fanqiang ; Tang, Chao ; Zhou, Libang ; Lu, Zhaoxin ; Lu, Yingjian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-f8f0b8dab2876186bf40b1b43597f62ddd6de86f230240827ea7ec259fcf1f333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acne</topic><topic>Acne Vulgaris - drug therapy</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Antiacne agents</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnological Products and Process Engineering</topic><topic>Biotechnology</topic><topic>Catalase</topic><topic>Cholesterol</topic><topic>Colonies</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines</topic><topic>Epidermis</topic><topic>Erythema</topic><topic>Fatty acids</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukins</topic><topic>Life Sciences</topic><topic>Linoleic acid</topic><topic>Mice</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>NF-kappa B</topic><topic>NF-κB protein</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Organic Chemicals</topic><topic>Oxidative stress</topic><topic>Peroxidase</topic><topic>Propionibacterium acnes</topic><topic>Signal transduction</topic><topic>Superoxide dismutase</topic><topic>Surface active agents</topic><topic>Surfactin</topic><topic>Testing</topic><topic>TLR2 protein</topic><topic>Toll-like receptors</topic><topic>Triglycerides</topic><topic>Tumor necrosis factor-α</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shan, Mengyuan</creatorcontrib><creatorcontrib>Meng, Fanqiang</creatorcontrib><creatorcontrib>Tang, Chao</creatorcontrib><creatorcontrib>Zhou, Libang</creatorcontrib><creatorcontrib>Lu, Zhaoxin</creatorcontrib><creatorcontrib>Lu, Yingjian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>ProQuest_ABI/INFORM Collection</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>Biology 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Yingjian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2022</date><risdate>2022</risdate><volume>106</volume><issue>2</issue><spage>549</spage><epage>562</epage><pages>549-562</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Accumulating evidence suggested that suppression of
Propionibacterium acnes-
induced inflammation was a promising strategy to alleviate acne vulgaris. This study evaluated the alleviating effect of surfactin-oleogel on
P. acnes
-induced inflammatory acne vulgaris in mice. Epidermis morphology and histopathological examination showed that surfactin-oleogel effectively ameliorated the
P. acnes
-induced epidermis swelling and erythema. Surfactin-oleogel reduced the epidermis thickness to 48.52% compared to the model control group. The colony of
P. acnes
in the epidermis was decreased by 1 log CFU/mL after receiving surfactin-oleogel treatment. Furthermore, surfactin-oleogel attenuated oxidative stress in the epidermis by increasing the activities of superoxide dismutase, catalase, and glutathione peroxidase. In addition, the expression of inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2, pro-inflammatory cytokines (e.g. tumour necrosis factor-α and interleukin-1β), and nuclear factor kappa-B in the epidermis were reduced after treating with surfactin-oleogel. Moreover, total cholesterol and free fatty acids were decreased, whereas the treatment of surfactin-oleogel increased triglycerides and linoleic acid content. Besides, immunohistochemical assay and real-time PCR analysis indicated that surfactin-oleogel blocked the TLR2-mediated NF-κB signalling pathways in the epidermis. Consequently, our results demonstrated that surfactin-oleogel had antibacterial and anti-inflammation activities to treat
P. acnes
-induced inflammatory acne vulgaris.
Key points
•
Surfactin-oleogel effectively relieves inflammation and oxidative stress caused by P. acnes.
•
Surfactin-oleogel effectively reduced the P. acnes colony.
•
Surfactin-oleogel relieves P. acnes-induced inflammation by inactivated the TLR-mediated NF-κB.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34939137</pmid><doi>10.1007/s00253-021-11719-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-9288-7419</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0175-7598 |
| ispartof | Applied microbiology and biotechnology, 2022, Vol.106 (2), p.549-562 |
| issn | 0175-7598 1432-0614 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2613292627 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Acne Acne Vulgaris - drug therapy Animals Anti-Inflammatory Agents - therapeutic use Antiacne agents Biomedical and Life Sciences Biotechnological Products and Process Engineering Biotechnology Catalase Cholesterol Colonies Cyclooxygenase-2 Cytokines Epidermis Erythema Fatty acids Glutathione Glutathione peroxidase IL-1β Inflammation Interleukins Life Sciences Linoleic acid Mice Microbial Genetics and Genomics Microbiology NF-kappa B NF-κB protein Nitric oxide Nitric-oxide synthase Organic Chemicals Oxidative stress Peroxidase Propionibacterium acnes Signal transduction Superoxide dismutase Surface active agents Surfactin Testing TLR2 protein Toll-like receptors Triglycerides Tumor necrosis factor-α Tumors |
| title | Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris induced by Propionibacterium acnes |
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