Pharmacokinetic evaluation of twice-a-week micafungin for prophylaxis of invasive fungal disease in children with acute lymphoblastic leukaemia: a prospective observational cohort study

Abstract Objectives To determine the pharmacokinetics of twice-a-week micafungin prophylaxis in paediatric leukaemic patients to provide the rationale for this approach. Methods Twice-a-week micafungin at a dose of 9 mg/kg (maximum 300 mg) was given during the leukaemic induction treatment with at l...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2022-02, Vol.77 (3), p.699-703
Hauptverfasser:	Bury, Didi, Wolfs, Tom F W, ter Heine, Rob, Muilwijk, Eline W, Tissing, Wim J E, Brüggemann, Roger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antifungal Agents Child Child, Preschool Echinocandins Humans Infant Invasive Fungal Infections - drug therapy Invasive Fungal Infections - prevention & control Lipopeptides Micafungin - pharmacokinetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Prospective Studies
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