Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling

Background and objectivesLiver fibrosis (LF) occurs following chronic liver injuries. Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain containing 5 (TXNDC5), an ER protein disulfide isomerase (PDI), as a critical mediator of cardiac and lung fibrosis. We ai...

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Veröffentlicht in:	Gut 2022-09, Vol.71 (9), p.1876-1891
Hauptverfasser:	Hung, Chen-Ting, Su, Tung-Hung, Chen, Yen-Ting, Wu, Yueh-Feng, Chen, You-Tzung, Lin, Sung-Jan, Lin, Shuei-Liong, Yang, Kai-Chien
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bile ducts Carbon tetrachloride Collagen (type I) Extracellular matrix Fibroblasts fibrogenesis Fibrosis Gene regulation gene targeting Growth factors hepatic stellate cell Hepatitis B Hepatitis C Hepatocytes Hepatology Infections Laboratories Liver Liver cancer Liver cirrhosis Patients Protein disulfide-isomerase Proteins Stellate cells Therapeutic targets Thioredoxin Transcription activation Transcriptomes Transforming growth factor-b1 Viral infections
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